Research Studies

Protocol Number Status
Buprenorphine-Precipitated Withdrawal Hotspots and Correlates CTN-0134 Development
Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials CTN-0133 Development
Ketamine for Methamphetamine Use Disorder Study CTN-0132 Development
Methadone or Enhanced Buprenorphine to Address Retention Among Patients not Optimally Benefitting from Office-based Buprenorphine – a Hybrid Effectiveness/Implementation Trial CTN-0131 Development
Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine CTN-0130 Development
The Great Plains Initiative CTN-0129 Development
Adherence and Feasibility of Wearable Technologies and Ecological Momentary Assessment to Assess Autonomic Function and Negative Affect in Opioid Use Disorder. CTN-0128 Development
Engaging African American Faith-based leaders in a Substance Use Learning Collaborative CTN-0127 Development
Longitudinal Follow-up of Individuals with Opioid Use Disorder CTN-0126 Development
Using Integrative Data Analysis to Examine the Impact of Psychosocial Treatments for Black Cocaine Users Enrolled in the CTN CTN-0125 Development
Assessment and Design of a Cost-Effective Collaborative MOUD Delivery System CTN-0124 Development
Facebook intervention for preventing opioid relapse among American Indian Women CTN-0123 Development
Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex CTN-0122 Development
Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders (SUD) among Hospitalized Patients CTN-0121 Development
R-Mist: Remote Methadone Ingestion Surveillance Trial CTN-0120 Development
Impact of Social Distancing Measures, Expansion of Telemedicine for Buprenorphine Prescribing, and Health Insurance Payor on Access to Buprenorphine During the COVID-19 Pandemic CTN-0119 Active
Examining the COVID-19 Public Health Emergency on Policy, Substance Use Disorder, Treatment and Resilience among American Indian and Alaska Native Communities CTN-0118 Development
The Impact of COVID-19 Pandemic on Substance Use Treatment Services CTN-0117 Development
Pharmacist-Integrated Model of Medication Treatment for Opioid Use Disorder CTN-0116 Development
Developing an Intervention to Address Intersecting Prescription Opioid and Chronic Pain Stigma in Cancer Survivors (NIH HEAL Initiative) CTN-0115 Active
Drug Repurposing for Cocaine Use Disorder (CUD) Using a Combined Strategy of Artificial Intelligence (AI)-Based Prediction and Retrospective Clinical Corroboration CTN-0114 Active
Validating a DSM-5 Substance Use Disorder (SUD) Symptom Checklist in EHR Data from a Large Primary Care Sample to Support Future Pragmatic Trials and Chronic Care Management of SUDs in Primary Care CTN-0113 Active
Optimal Policies to Improve Methadone Maintenance Adherence Long-Term (OPTIMMAL) CTN-0112 Development
COVID-19 and Substance Misuse Case Identification using Data Science: A Retrospective Cohort Study CTN-0111 Active
Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB) CTN-0110 Development
Innovative Development of Research Engagement Manual (I-DREM): Strategies to Enhance Recruitment and Retention of Black Individuals in CTN-0109 CURB-2 CTN-0109-A-1 Development
Randomized, Placebo-Controlled Trial of Injectable Naltrexone and Monthly Injectable Buprenorphine for Cocaine Use Disorder (CURB-2) CTN-0109 Development
Transcranial Magnetic Stimulation for the Treatment of Methamphetamine/Cocaine Use Disorder CTN-0108 Development
Peer Intervention to Link Overdose survivors to Treatment (PILOT) (NIH HEAL Initiative) CTN-0107 Development
Derivation and Validation of New Measurement-Based Care Tools Derived from the Brief Addiction Monitor (NIH HEAL Initiative) CTN-0106 Completed
Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative) CTN-0105 Development
Healthcare Provider Stigma Related to the Opioid Use Epidemic and its Impact on Patient Treatment and Clinical Management CTN-0104 Active
Expanding Clinical Research Training on Implementing the Evidence-based Hub and Spoke Model of Medication-Assisted Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0103 Completed
COVID Impact on Rural Expansion of Medication Treatment for Opioid Use Disorder CTN-0102-A-1 Active
Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0102 Active
Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative) CTN-0101 Active
Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative) CTN-0100 Active
Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative) CTN-0099 Active
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative) CTN-0098 Active
Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative) CTN-0097 Active
National Medication-Assisted Treatment Survey of Substance Use Disorder Programs Serving American Indian and Alaska Native People (NIH HEAL Initiative) CTN-0096-A-1 Active
Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative) CTN-0096 Active
Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians (NIH HEAL Initiative) CTN-0095-A-2 Active
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder (NIH HEAL Initiative) CTN-0095-A-1 Active
Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative) CTN-0095 Active
Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative) CTN-0094 Active
Validation of a Community Pharmacy-based Prescription Drug Monitoring Program Risk Screening Tool (PHARMSCREEN) (NIH HEAL Initiative) CTN-0093 Completed
Preventing and Identifying Opioid Use Disorder using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative) CTN-0091 Completed
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative) CTN-0090 Completed
Integrating Nurse Practitioner Buprenorphine Waiver Training into Graduate Nursing Curriculum (NIH HEAL Initiative) CTN-0089 Completed
DC Research Infrastructure Building & Initiative to Reach, Engage, and Retain in MAT patients with OUD (NIH HEAL Initiative) CTN-0088 Active
A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative) CTN-0087 Completed
Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative) CTN-0086 Completed
Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative) CTN-0085 Completed
Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder (D-TECT) (NIH HEAL Initiative) CTN-0084-A-2 Active
Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality (NIH HEAL Initiative) CTN-0084-A-1 Completed
Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative) CTN-0084 Completed
Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services CTN-0083 Completed
Vaccine Readiness in People Who Use Substances In Community STI Clinics and Substance Use Intervention or Harm Reduction Programs In Eight Higher HIV Incidence Southeastern Cities CTN-0082-A-1 Completed
Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and MSM-Centered Community Based Organizations (CBOs) CTN-0082 Completed
Emergency Medicine Opioid Data Infrastructure: Key Venue to Address Opioid Morbidity and Mortality (Project CODE PRO – Capturing Opioid Use Disorder Electronically and Patient Reported Outcomes) CTN-0081 Completed
Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (NIH HEAL Initiative) CTN-0080 Active
Ancillary Study of the Adoption and Sustainability of ED-Initiated Buprenorphine (NIH Heal Initiative) CTN-0079-A-1 Active
Emergency Department Connection to Care with Buprenorphine for Opioid Use Disorder (ED-CONNECT) CTN-0079 Completed
Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities CTN-0078 Completed
Medical Cannabis Use among Primary Care Patients: Using Electronic Health Records to Study Large Populations CTN-0077 Completed
Clinical decision support for Opioid use disorders in Medical settings: Pilot Usability Testing in an EMR (COMPUTE) CTN-0076 Completed
Pharmacy Screening and Collaborative Opioid Use Disorder Care (Pharm-OUD-Care) CTN-0075 Completed
Primary Care Opioid Use Disorders Treatment Trial Economic Analysis Study (NIH HEAL Initiative) CTN-0074-A-1 Completed
Primary Care Opioid Use Disorders Treatment Trial CTN-0074 Completed
Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network CTN-0073 Completed
Patient and System-Level Factors Associated with HEDIS AOD-IET Measure Performance across Health Systems CTN-0072 Completed
Electronic Health Records Data Elements Research (EHR-DARE) CTN-0071 Completed
Interpretation and Implementation of Title 42 CFR Part 2 for Confidentiality of Patient Drug and Alcohol Use Records: NIDA CTN Stakeholder Snapshot CTN-0070 Completed
Opioid Use Disorder in the Emergency Department CTN-0069 Completed
Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder CTN-0068 Completed
Comparing Treatments for HIV-Positive Opioid Users in an Integrated Care Effectiveness Study (CHOICES); Scale-Up CTN-0067 Completed
Opioid Use Disorders in Primary Care Settings: Linking EHRs with PDMP and National Death Index Data Systems CTN-0066 Completed
Evaluation of Drug Screening Implementation in Primary Care CTN-0065 Completed
Linkage to Hepatitis C Virus Care among HIV/HCV Co-infected Substance Users CTN-0064 Completed
Gender Differences in the Interrelationships between Sexual Abuse, Risky Sexual Behavior, and Anxiety/Depression in Treatment Efficacy and Drug Use over Time among Individuals with Substance Use Disorders CTN-0063 Completed
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements into the Electronic Health Record in Large Primary Care Settings CTN-0062 Completed