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Home » CCTN » CTN » Research Studies

Research Studies
Protocol Number Status
Expanding Clinical Research Training on Implementing the Evidence-based Hub and Spoke Model of Medication-Assisted Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0103 Development
Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0102 Development
Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative) CTN-0101 Development
Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative) CTN-0100 Development
Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative) CTN-0099 Development
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative) CTN-0098 Development
Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative) CTN-0097 Development
Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative) CTN-0096 Development
Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative) CTN-0095 Development
Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative) CTN-0094 Development
Validation of a Community Pharmacy-based Prescription Drug Monitoring Program Risk Screening Tool (PHARMSCREEN) (NIH HEAL Initiative) CTN-0093 Development
OUD Phenotyping Feasibility for Clinical Trials (NIH HEAL Initiative) CTN-0092 Development
Preventing and Identifying Opioid Use Disorder using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative) CTN-0091 Development
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative) CTN-0090 Development
Integrating Nurse Practitioner Buprenorphine Waiver Training into Graduate Nursing Curriculum (NIH HEAL Initiative) CTN-0089 Development
DC Research Infrastructure Building & Initiative to Reach, Engage, and Retain in MAT patients with OUD (NIH HEAL Initiative) CTN-0088 Development
A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative) CTN-0087 Development
Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative) CTN-0086 Development
Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative) CTN-0085 Development
Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative) CTN-0084 Development
Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services CTN-0083 Development
Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and MSM-Centered Community Based Organizations (CBOs) CTN-0082 Development
Emergency Medicine Opioid Data Infrastructure: Key Venue to Address Opioid Morbidity and Mortality (Project CODE PRO – Capturing Opioid Use Disorder Electronically and Patient Reported Outcomes) CTN-0081 Development
Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations CTN-0080 Development
Emergency Department Connection to Care with Buprenorphine for Opioid Use Disorder (ED-CONNECT) CTN-0079 Active
Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities CTN-0078 Active
Medical Cannabis Use among Primary Care Patients: Using Electronic Health Records to Study Large Populations CTN-0077 Active
Clinical decision support for Opioid use disorders in Medical settings: Pilot Usability Testing in an EMR (COMPUTE) CTN-0076 Active
Pharmacy Screening and Collaborative Opioid Use Disorder Care (Pharm-OUD-Care) CTN-0075 Active
Primary Care Opioid Use Disorders Treatment Trial Economic Analysis Study (NIH HEAL Initiative) CTN-0074-A-1 Development
Primary Care Opioid Use Disorders Treatment Trial CTN-0074 Active
Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network CTN-0073 Completed
Patient and System-Level Factors Associated with HEDIS AOD-IET Measure Performance across Health Systems CTN-0072 Completed
Electronic Health Records Data Elements Research (EHR-DARE) CTN-0071 Completed
Interpretation and Implementation of Title 42 CFR Part 2 for Confidentiality of Patient Drug and Alcohol Use Records: NIDA CTN Stakeholder Snapshot CTN-0070 Completed
Opioid Use Disorder in the Emergency Department CTN-0069 Active
Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder CTN-0068 Active
Comparing Treatments for HIV-Positive Opioid Users in an Integrated Care Effectiveness Study (CHOICES); Scale-Up CTN-0067 Active
Opioid Use Disorders in Primary Care Settings: Linking EHRs with PDMP and National Death Index Data Systems CTN-0066 Completed
Evaluation of Drug Screening Implementation in Primary Care CTN-0065 Completed
Linkage to Hepatitis C Virus Care among HIV/HCV Co-infected Substance Users CTN-0064 Completed
Gender Differences in the Interrelationships between Sexual Abuse, Risky Sexual Behavior, and Anxiety/Depression in Treatment Efficacy and Drug Use over Time among Individuals with Substance Use Disorders CTN-0063 Completed
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements into the Electronic Health Record in Large Primary Care Settings CTN-0062 Active
Kaiser Virtual Data Warehouse - Prescription Opioid Users CTN-0061 Completed
Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief screen/assessment tool (TAPS Tool) CTN-0059 Completed
Screening, Brief Intervention, and Referral to Treatment in Primary Care (SBIRT-PC): An add-on project to “Duke University CMS Innovation Award Southeastern Diabetes Initiative” CTN-0057 Completed
Testing and Linkage to HIV Care in China: a Cluster Randomized Trial CTN-0056 Completed
Comparing Treatments for HIV-Positive Opioid Users in an Integrated Care Effectiveness Study (CHOICES) CTN-0055 Completed
Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT) CTN-0054 Completed
Achieving Cannabis Cessation: Evaluating N-Acetylcysteine Treatment (ACCENT) CTN-0053 Completed
A Randomized Controlled Evaluation of Buspirone for Relapse-Prevention in Adults with Cocaine Dependence (BRAC) CTN-0052 Completed
Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT) CTN-0051 Completed
The START Follow-Up Study CTN-0050 Completed
Project HOPE: Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users CTN-0049 Completed
Cocaine Use Reduction with Buprenorphine (CURB) CTN-0048 Completed
Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED) CTN-0047 Completed
Smoking-Cessation and Stimulant Treatment (S-CAST): Evaluation of the Impact of Concurrent Outpatient Smoking-Cessation and Stimulant Treatment on Stimulant-Dependence Outcomes CTN-0046 Completed
Web-delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders CTN-0044 Completed
Stimulant Reduction Intervention using Dosed Exercise CTN-0037 Completed
HIV Rapid Testing and Counseling in Drug Abuse Treatment Programs in the U.S. CTN-0032 Completed
An Evaluation of Neurocognitive Function, Oxidative Damage, and their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers CTN-0031-A-1 Completed
Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement CTN-0031 Completed
Prescription Opioid Addiction Treatment Study (POATS) CTN-0030 Completed
A Pilot Study of Osmotic-Release Methylphenidate (OROS-MPH) in Initiating and Maintaining Abstinence in Smokers with Attention Deficit Hyperactivity Disorder (ADHD) CTN-0029 Completed
Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS-MPH) for Attention Deficit Hyperactivity Disorder in Adolescents with Substance Use Disorders CTN-0028 Completed
Starting Treatment with Agonist Replacement Therapies (START) Study CTN-0027 Completed
Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse CTN-0021 Completed
Job-Seekers Training for Patients with Drug Dependence CTN-0020 Completed
Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment CTN-0019 Completed
Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment CTN-0018 Completed
HIV and HCV Intervention in Drug Treatment Settings CTN-0017 Completed
Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment CTN-0016 Completed
Women's Treatment for Trauma and Substance Use Disorders CTN-0015 Completed
Brief Strategic Family Therapy (BSFT) for Adolescent Drug Abusers CTN-0014 Completed
Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome in Pregnant Substance Users CTN-0013 Completed
Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs CTN-0012 Completed
A Feasibility Study of a Telephone Enhancement Procedure (TELE) To Improve Participation in Continuing Care Activities CTN-0011 Completed
Buprenorphine/Naloxone (Bup/Nx) Facilitated Rehabilitation for Heroin Addicted Adolescents/Young Adults CTN-0010 Completed
Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs CTN-0009 Completed
A Baseline for Investigating Diffusion of Innovation CTN-0008 Completed
Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics CTN-0007 Completed
Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics CTN-0006 Completed
Motivational Interviewing (MI) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse CTN-0005 Completed
MET (Motivational Enhancement Treatment) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse CTN-0004 Completed
Suboxone® (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules CTN-0003 Completed
Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Outpatient Opiate Detoxification CTN-0002 Completed
Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Inpatient Opiate Detoxification CTN-0001 Completed

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