Longitudinal Follow-up of Individuals with Opioid Use Disorder

The primary aim of the Longitudinal Follow-up of Individuals with Opioid Use Disorder (LFU-OUD) study is to establish initial and long-term feasibility of participant registration, retention, engagement, and data collection in a longitudinal study, linked to participating CTN clinical trials, that follows individuals with OUD. Secondary aims will address key scientific questions using core follow-up data and trial-specific longitudinal data elements for participating trials. Scientific inquiries will be geared toward investigating questions such as: characterizing the long-term course of OUD (outcomes of opioid and other substance use, mortality, functional outcomes and engagement in treatment); evaluating treatment participation status at follow-up, treatment retention over time, and effects of each type of opioid replacement treatment on opioid use and other recovery milestones; and identifying predictors of long-term OUD outcomes (treatment-related factors (e.g., type of MOUD), participant sociodemographic characteristics, and participant clinical factors (e.g., co-occurring psychiatric disorders).