What We Do:
GEDN supports research on the genetics, and epigenetics, and developmental mechanisms that underlie addiction and substance abuse.
- Development of neural pathways and brain structures that mediate drug abuse and addiction. This includes research on stem cell and progenitor cell induction, pattern formation, proliferation, and phenotypic restriction, specification of neuronal and glial cell fate, programmed cell death, guidance of glial and neuronal migration, and regulation of dendritic and axonal outgrowth, navigation, target selection, and synapse formation.
- The role that transcription factors, non-coding RNAs, scaffolding proteins, adhesion molecules, signaling molecules, cytoskeletal proteins, and other molecules play in mediating memory and learning and the neural adaptation to drugs of abuse.
- Cell biology studies of addiction, including research on membrane and protein trafficking, signal transduction pathways, cytoskeletal rearrangements, protein-protein interactions, protein complex formation, synaptic vesicle formation, and ion movements.
- Genetic studies of vulnerability to addiction, including animal and human molecular genetics studies, QTL-based research, and pharmacogenetics.
- Epigenetics mechanisms of substance abuse and addiction including chromatin modification and non-coding RNAs.
- Molecular genetics and genomics studies related to underlying biology of the response to drugs of abuse, including model organism genomics, functional genomics, proteomics, gene expression studies, and mutagenesis studies.
Staff Research Interests:
- Jonathan Pollock, Ph.D. - Branch Chief
Dr. Pollock manages and oversees all activities of the GMNRB. Dr. Pollock continues to advocate for genetics, proteomics and developmental biology research at NIDA. Under his leadership the NIDA Genetic Consortium was established that led to the discovery that the nicotinic receptors chrna5, Chrnb4, and chrna3 are associated with nicotine addiction, lung cancer, and peripheral artery disease. He also took a leadership role in the development of the Knockout Mouse Project. He plays an active role in the NIH BRAIN Initiative on the Cell Census. His portfolio focuses on the genetic and epigenetics mechanisms of addiction in humans and modeled in non-human organisms.
Activities: NIDA Genetics Workgroup, chair; NIDA Neuroscience Consortium, GTEx working group, BRAIN cell census working group, NIH Neuroscience Blueprint Coordinating Committee
- Da-Yu Wu, Ph.D. - Health Scientist Administrator
Dr. Wu's programmatic interest is developmental neurobiology. He oversees efforts on the research in the development and plasticity of the reward and motivation pathways with particular emphasis on prenatal and adolescent period of exposure to drugs of abuse, focusing on synapse growth and modulation, axonal pathfinding and neural circuitry establishment. He also has strong interests in neuronal/glial cell fate, differentiation and stem cell biology. His portfolio in addition includes areas of cell and molecular imaging, animal modeling of drug abuse, and RNA regulation during neural development.
Activities: Member of the Trans-NIH Stem Cell Committee, NIDA AIDS Workgroup, and NIDA Genetics Workgroup.
- John Satterlee, Ph.D. - DNB Coordinator for Trans-NIH Programs and Activities
Dr. Satterlee oversees a broad range of grants and activities focused on molecular regulation of drug abuse phenotypes including genomic, epigenomic, regulatory RNA, epitranscriptomic, and systems biology studies. This includes the use of model organisms to answer fundamental questions in drug abuse biology and behavioral plasticity. Other areas of interest include the development of molecular technologies for imaging and manipulation of neuronal gene expression, integration and analysis of molecular datasets, extracellular vesicles, nuclear architecture, nucleosynaptic communication and intergenerational inheritance. He also oversees a program investigating molecular aspects of HIV/AIDS progression and latency and their interaction with substance abuse.
Activities: Common Fund Roadmap Epigenomics Program (co-coordinator), International Human Epigenome Consortium (representative), CF 4D-Nucleome Program (project lead), CF Extracellular RNA Communication Program (project lead), NIH Neuroscience Blueprint Coordinating Committee, Trans-NIH Transgenerational Workgroup, NIDA Genetics Workgroup, and NIDA Neuroscience Consortium.