NIDA Genetic Consortium Meetings & Abstracts | National Institute on Drug Abuse (NIDA)

May 2023 Meeting

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Please register for the meeting here: https://apps1.seiservices.com/NIDA/GeneticsConsortium/Registration.aspx

Meeting Dates and Times

Tuesday, May 16^th: - 9:00 a.m. to 5:30 p.m.
Wednesday, May 17^th - 9:00 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

May 16 – Keynote (9:15 am – 9:45 am)
Time	First Name	Last Name	Email	Abstract Title
9:15	Andre	Toussaint	at3658@columbia.edu	Understanding Substance Abuse from Scientific and Human Perspectives

May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:45	Kristen	Maynard	kristen.maynard@libd.org	Integrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain
10:00	Marine	Salery	marine.salery@mssm.edu	Capturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens.
10:15	Jennifer	Tuscher	jtuscher@uab.edu	Multiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience
10:30	Benjamin	Reiner	bcreiner@pennmedicine.upenn.edu	Single nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine

May 16 – Special Presentation (11:00 am – 11:10 am)
Time	First Name	Last Name	Email	Abstract Title
11:00	Anita	Bandrowski	bandrow@gmail.com	RRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines

May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs
Time	First Name	Last Name	Email	Abstract Title
2:00	Carl	Lin	zlin@mclean.harvard.edu	History and Application of Artificial Intelligence: Its Turn for Genomics
2:00	Sara	Mostafavi	saramos@cs.washington.edu	Sequence-based deep learning models for predicting molecular phenotypes
2:15	Hongyang	Li	Hongyang.Li@ibm.com	Asymmetric Predictive Relationships Across Histone Modifications
2:30	Andreas	Pfenning	apfenning@cmu.edu	Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics

May – 16 Session 3 (4:30 pm – 5:20 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:30	Alexander	Hatoum	ashatoum@wustl.edu	Multivariate genome-wide assocation meta-analysis of 1 million subjects identifies loci underlying multiple substance use disorders
4:40	Jeffrey	Hatfield	jshatfi@g.clemson.edu	Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel
4:50	Chelsie	Benca-Bachman	chelsie.benca@emory.edu	Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences Among African Americans
4:55	Xiufang (Nadine)	Guo	xguo@mail.ucf.edu	Development of an iPSC-preBötC neuron opiate overdose and recovery multi-organ platform
5:00	Jennifer	Kelschenbach	jennifer.kelschenbach@mssm.edu	Morphine dependence accelerates HIV-associated neurocognitive impairment in EcoHIV infected mice
5:05	Salma	Majid	majidsn@nih.gov	Recurrent and non-recurrent copy number variants in American Indian tribes with substance use disorders
5:10	Freddyson	Martinez-Rivera	freddyson.martinez-rivera@mssm.edu	Cellular and transcriptional contributions of the nucleus accumbens in transferring extinction-based memories
5:15	Evaristus	Nwulia	enwulia@howard.edu	Linking Cannabis Use Disorder, Long-noncoding RNA and Olfactory Structure and Function

May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:00	Elizabeth	Heller	eheller@pennmedicine.upenn.edu	Cocaine regulation of alternative splicing via changes in histone postranslational modifications.
9:15	Zijun	Wang	zjwang@ku.edu	DNA damage and repair processes are involved in opioid addiction
9:30	Zhuzhu	Zhang	zhuzhuzhang@uchicago.edu	Epigenomic remodeling at single cell resolution in cocaine self-administration in mice
9:45	BaDoi	Phan	badoi.phan@pitt.edu	Whole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants

May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs
Time	First Name	Last Name	Email	Abstract Title
1:15	Holly	Poore	holly.poore@rutgers.edu	Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
1:45	Huda	Akil	akil@umich.edu	Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00	Michael	Sheldon	michael.sheldon@sampled.com	Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse

May – 17 Session 6 (4:00 pm – 4:50 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:00	Amrit	Koirala	amrit.koirala@bcm.edu	Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10	Vivek	Philip	Vivek.Philip@jax.org	Enumeration and visualization of differential gene co-expression response to cocaine
4:20	Janitza	Montalvo-Ortiz	janitza.montalvo-ortiz@yale.edu	Deciphering the role of DNA hydroxymethylation in substance use disorders
4:25	MadhurBain	Singh	singhm18@vcu.edu	Examining Bidirectional Causal Effects between Smoking and DNA Methylation using Epigenetic Mendelian Randomization Analyses
4:30	Alyssa	Wilson	alyssa.wilson@mssm.edu	Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35	Francesca	Telese	ftelese@health.ucsd.edu	Analysis of single nuclei RNA-seq from the nucleus accumbens of heterozygous reeler mice exposed to THC during adolescence suggests a link between THC exposure, Reelin signaling, and vulnerability to human psychiatric disorders
4:40	Jared	Bagley	jbagley@binghamton.edu	Neuron navigator 1 regulates the self-administration of cocaine
4:45	Laura	Saba	Laura.Saba@cuanschutz.edu	Multi-omic single nuclei data provide insight into the cellular origin of whole brain coexpression patterns related to Oprm1

May 16 – Poster Session A (11:10 am – 12:40 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Arpana	Agrawal	arpana@wustl.edu	The Psychiatric Genomics Consortium Substance Use Disorders Working Group (PGC-SUD): An Update
2	Schahram	Akbarian	schahram.akbarian@mssm.edu	Single Nucleus Transcriptomic Profiling of Human Ventral Midbrain Reveals Widespread Activation of Multiple Glial Subtype
3	Muhammad	Arshad	muhammadwaqar.arshad@yale.edu	Substance Abuse in Pakistan: Clinical Issues and Research Opportunities
4	Bao-Zhu	Yang	bao-zhu.yang@yale.edu	Inter-Linking the Developmental Brain Transcriptome and GWAS Risk Variants Revealed Neural Circuits Prognostic of Nicotine Use Severity
5	David	Ashbrook	dashbrook@UTHSC.edu	Good wine and old data get better with age: New insights on gene-by-environment effects of drugs of abuse in mice using GeneNetwork.org
6	Christopher	Baker	christopher.baker@jax.org	Genetic variation influences cell specific cis-regulatory landscape in the mouse striatum
7	Madelyn	Baker	mrb4002@med.cornell.edu	Epigenetic representation of cocaine-context association in the dorsal dentate gyrus of male mice
8	Britahny	Baskin	britty@bu.edu	Premorbid addiction model traits and cocaine stimulant sensitivity in spontaneously hypertensive rat (SHR) substrains
9	Jacob	Beierle	Jacob.Beierle@jax.org	A high-throughput machine vision-based univariate scale for pain and analgesia in mice
10	Aritra	Bhattacherjee	writetoab@gmail.com	Decoding molecular organization of the brain reward circuit for understanding mechanisms of drug addiction
11	Chuan	Bi	chuan.bi@som.umaryland.edu	Multivariate Mediation Analysis of Genetic Variants, Brain Connectome and Nicotine Addiction
12	Fatah	Kashanchi	fkashanc@gmu.edu	Retroviral infection of human neurospheres and use of stem cell EVs to repair cellular damage
13	Kasey	Brida	kbrida@uab.edu	Reelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates medium spiny neuron physiology and behavioral response to cocaine
14	Russell	Brown	BROWN1@mail.etsu.edu	Analysis of the enhanced rewarding effects of nicotine and underlying neuroplasticity mechanisms in a heritable model of drug abuse vulnerability in psychosis
15	Caleb	Browne	caleb.browne@mssm.edu	Transcriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
16	Edward	Browne	epbrowne@email.unc.edu	Defining the impact of cannabis use on immune cell phenotypes and the latent viral reservoir in people with HIV.
17	Camron	Bryant	camron@bu.edu	Spectrotemporal USV profiles during neonatal opioid withdrawal in FVB substrains, Zhx2-edited BALB/c substrains, and outbred CFW mice
18	Jason	Bubier	Jason.Bubier@jax.org	A Tale of Two Opioids: The Genetics of Opioid Induced Respiratory Depression in Response to Fentanyl and Morphine in Mice.
19	Belle	Buzzi	buzzib@vcu.edu	Nicotine reward and preference in C57BL/6J and C57BL/6N mouse strains
20	Jean Lud	Cadet	jcadet@intra.nida.nih.gov	Compulsive methamphetamine intake and abstinence in the presence of punishment are associated with differential hydroxymethylation of miRNAs in the rat nucleus accumbens
21	Cali	Calarco	ccalarco@som.umaryland.edu	Mitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine in C57Bl/6 mice
22	Rianne	Campbell	rcampbell@som.umaryland.edu	Baseline Characterizations of Novel D1R-CRISPRa and A2A-CRISPRa Mouse Lines
23	Javan	Carter	JCarter@rti.org	Identifying novel genes and pathways associated with opioid overdose death via meta-analysis of differential gene expression.
24	Samantha	Cheeks	scheeks@uci.edu	Cannabidiol Attenuates Nicotine Self-Administration and Withdrawal Symptomology in Mice
25	Jixin	Chen	chenj@ohio.edu	A single-molecule FRET data fitting package for DNA folding kinetic study
26	Yong	Chen	chenyong@rowan.edu	Inferring Memory-related Regulatory Modules in Engram Cells by Deep-learning and scRNA-seq Data
27	Olivia	Corradin	corradin@wi.mit.edu	Case-specific epigenetic alterations converge on key genes linked to opioid overdose
28	Daniel	Wood	woodda@musc.edu	HDAC5 intrinsic enzymatic activity limits drug-seeking behavior
29	Santiago	Cuesta	santiago.cuesta@rutgers.edu	Gut Microbiota Composition Modulates Cocaine-Induced Neurobehavioral Plasticity
30	Eamonn	Duffy	Eamonn.Duffy@colorado.edu	Characterization of thermal and mechanical sensitivity in select strains of the Hybrid Rat Diversity Panel
31	Soren	Emerson	soren.d.emerson@vanderbilt.edu	Lysine acetyltransferase KAT2a is a novel cocaine-recruited epigenetic regulator in the nucleus accumbens
32	Dan	Fabris	dan.fabris@uconn.edu	Investigating epitranscriptomic communications between HIV-1 infection and neuromodulator response in different CNS cells
33	Fang	Fang	ffang@rti.org	A DNA methylation-based classifier for lifetime cannabis use
34	J. Adam	Fields	jafields@health.ucsd.edu	Effects of cannabinoids on phenotype of patient monocyte-derived macrophages vary by cannabis use patterns
35	Zoe	Figueroa	zoe.figueroa@email.ucr.edu	Astrocytic contributions to chronic methamphetamine induced neuroinflammation and disease
36	Prescilla	Garcia-Trevizo	pjg5435@psu.edu	Long-term Effects of Adolescent Nicotine Exposure on Sensitivity and Cotinine in the Diversity Outbred Mouse Population.
37	Paige	Lemen	plemen1@uthsc.edu	Adolescent Social Isolation Increases Vulnerability to Voluntary Opioid Consumption in Adulthood in Rats
38	Mudit	Tyagi	Mudit.Tyagi@jefferson.edu	Cocaine by co-stimulating NF-kB, NFAT, and AP-1 enhances CD4+ T-cells metabolism; thus, sensitizes partially active cells for HIV infection
39	Min-Ae	Song	song.991@osu.edu	Epigenetic Aging in the Human Lung: Focus on Smoking and Vaping

May 16 – Poster Session B (3:00 pm – 4:30 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Vivek	Swarup	vswarup@uci.edu	Investigating multi-omic Mechanisms Underlying Opioid Addiction Vulnerability: A Multi-Omics Study
2	Colin	Hodgkinson	chodg@mail.nih.gov	Alcohol and stress additively accelerate epigenetic cellular age
3	Rodrigo	Grassi-Oliveira	rogo@clin.au.dk	Exposomics of Cocaine Use Disorder: A new paradigm to study the impact of environmental exposures in Substance Use Disorders
4	Benjamin	Grissom	BGrissom@som.umaryland.edu	Heroin-induced genomic regulation of ventral pallidum and nucleus accumbens neuron subtypes
5	Petar	Grozdanov	petar.grozdanov@ttuhsc.edu	The role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption
6	Hongsheng	Gui	hgui1@hfhs.org	Bivariate relationship between opioid use disorder and suicide attempts despite mental health
7	Megan	Hagenauer	hagenaue@umich.edu	The Brain Data Alchemy Project: Teaching Research Reproducibility and Discovery Science While Mining Gold from Archived Genomics Data
8	Nikhil	Hajirnis	nhajirnis@som.umaryland.edu	Epigenomic editing of nucleus accumbens neuron subtypes using the CRISPR-Cas12f derived system
9	Peter	Hamilton	peter.hamilton@vcuhealth.org	Synthetic transcription factors, delivered to mouse nucleus accumbens, dysregulate drug-specific transcription and behaviors
10	Shuanglin	Hao	shao@med.miami.edu	Loss of Sirt3 induced by HIV gp120 with morphine in neuropathic pain, is mediated by H3K27me3 in the spinal cord
11	Emily	Hartwell	Emily.Hartwell@pennmedicine.upenn.edu	Performance of a polygenic risk score for depression in a deeply phenotyped sample
12	Ying	He	yhe@midwestern.edu	Epigenetic regulation of opioid dependence by microRNAs
13	Elaine	Hebda-Bauer	hebda@med.umich.edu	Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats
14	Ming-Fen	Ho	ho.mingfen@mayo.edu	Epigenetic Regulation of GABA Catabolism in iPSC-derived Neurons: the Role of FGF21
15	Leanne	Holt	leanne.holt@mssm.edu	Elucidation of the astrocyte-specific transcriptome following cocaine self-administration
16	Spencer	Huggett	shuggett91@gmail.com	In Silico Genetic & Neuromolecular Drug Repurposing for Opioid Use Disorder
17	Alvin	Jeffery	alvin.d.jeffery@vanderbilt.edu	Detecting Opioid Use Disorders in the Electronic Health Record to Support Genetic Studies: Adaptation of the Addiction Behaviors Checklist
18	Thomas	Jhou	jhou@musc.edu	Heritability and GWAS analyses of punishment sensitivity and cocaine avoidance in HS rats
19	Kan	Shao	kshao@indiana.edu	Dose-Response Analysis to Advance Gene and Pathway Identification for Risk Estimation of Substance Use Disorder
20	Guochun	Jiang	jianggc@gmail.com	Epigenetic regulation of a persistent HIV reservoir in human brain myeloid cells despite durable ART
21	Emma	Johnson	emma.c.johnson@wustl.edu	Cross-disorder analysis of cannabis use disorder and schizophrenia reveals convergent and divergent genetic influences
22	Yonwoo	Jung	yonwoo.jung@nih.gov	Mitochondrial Dysfunction and Oxidative Stress: Conserved Functional Phenotypes in Cocaine Addiction across Multiple Brain Regions
23	Marcus	Kaul	Marcus.Kaul@medsch.ucr.edu	Methamphetamine promotes in macrophages stimulated with LTR mimic ssRNA40 expression of HIV-regulating lncRNA HEAL and pro-inflammatory factors but suppresses the interferon response
24	Panjun	Kim	pkim11@uthsc.edu	3D Chromatin Interaction Data Facilitates de novo Genome Assembly and Identifies Promoter-Enhancer Interaction in the PFC of Rats
25	Cassandra	Kooiker	ckooiker@uci.edu	Genetic tagging uncovers a role for the thalamic paraventricular nucleus in mediating aberrant reward behaviors following adverse experiences early in life
26	Brittany	Kuhn	kuhnb@musc.edu	Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
27	Ashley	Kumar	avkumar@ucsd.edu	Transcriptional initiation profiling of primary brain cells to study stimulus-dependent enhancer activity
28	Valeria	Lallai	vlallai@uci.edu	THC- and Nicotine-Induced Changes in Central and Peripheral Extracellular Vesicle RNA Cargo
29	Eva	Lancaster	Eva.Lancaster@vcuhealth.org	Examining polygenic risk score by environment interaction on the relationship between interpersonal violence exposure and alcohol use in an ancestrally diverse college cohort
30	Paige	Lemen	plemen1@uthsc.edu	Opiate responses are controlled by interactions of Oprm1 and Fgf12 loci in rodents: Correspondence to human GWAS findings
31	Michael	Leone	mleone@andrew.cmu.edu	Spinal cord neuronal subtypes conserved across species are genetically implicated in chronic pain disorders
32	Dongmei	Li	Dongmei_Li@urmc.rochester.edu	Longitudinal changes in expression profile of urine exosomal epigenetic microRNAs in exclusive electronic cigarette adult users
33	Xiaoyu	Liang	xiaoyuliang@msu.edu	DNA Methylation-Based Telomere Length Is Associated With HIV Frailty and All-Cause Mortality
34	Carl	Litif	clitif@uwyo.edu	Identifying reward-specific transcriptomes underlying polyreward seeking ensembles in the nucleus accumbens core and prelimbic cortex
35	Shirelle	Liu	liu00459@umn.edu	Differential gene expression and epigenetic regulation in the medial prefrontal cortex of rats showing vulnerability to opioid addiction
36	Jennifer	Loftis	loftisj@ohsu.edu	Plasma extracellular vesicles and their miRNA cargo as biosignatures for neuropsychiatric impairments in methamphetamine use disorders
37	Ryan	Logan	Ryan.Logan@umassmed.edu	Elevated DNA damage and inflammatory markers in specific striatal cell types associated with opioid use disorder using single nuclei RNAseq in human postmortem brain
38	Falk	Lohoff	falk.lohoff@nih.gov	Additive Effects of Stress and Alcohol on Epigenetic Aging
39	Samikkannu	Thangavel	thangavel@tamu.edu	Epigenetic signature of N-terminal acetyltransferases role in HIV-Neuropathogenesis

May 17 – Poster Session C (10:15 am – 11:45 am)
Poster #	First Name	Last Name	Email	Abstract Title
1	Alice	Min	Alice.Min@mountsinai.org	A novel humanized mouse model to track active and latent CNS HIV-1 infection and to test therapeutic interventions
2	Luis	Araujo	ldearaujo@unimelb.edu.au	Power, measurement error and pleiotropy robustness in twin design extensions to Mendelian randomization
3	Paige	Lemen	plemen1@uthsc.edu	Oxycodone oral self-administration in inbred rats identifies different patterns of vulnerability
4	Andrew	Lombardi	anlo5057@colorado.edu	Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
5	Shahrdad	Lotfipour	shahrdadlotfipour@me.com	Functional Role of a Human 3'UTR Alpha6 Nicotinic Receptor Polymorphism (rs2304297) in Adolescent Substance Use
6	Qing	Lu	lucienq@ufl.edu	Kernel Neural Networks for Analyzing Large-scale Substance Use Disorders Genetic Data
7	William	Lynch	wlynch@bu.edu	Validating Zhx2 in oxycodone metabolite (oxymorphone) brain concentration and behavior via reciprocal gene editing and viral manipulation of gene expression in BALB/c substrains
8	Tianzhou	Ma	tma0929@umd.edu	Bayesian indicator variable selection for multivariate response with application to multi-trait fine mapping
9	Scott	Mackey	msmackey@uvm.com	ENIGMA Addiction: Neuroimaging Biotypes Supported by Gene Enrichment Analysis
10	Rajtarun	Madangopal	rajtarun.madangopal@nih.gov	In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
11	Travis	Mallard	tmallard@mgh.harvard.edu	Limited evidence for a general dimension of impulsivity across genomic, transcriptomic, and neuroanatomical levels of analysis
12	Lisa	Maturin	lmaturin@health.ucsd.edu	The Addiction Biobanks: : Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
13	Nicola	Micali	nicola.micali@yale.edu	The effect of prenatal cannabinoid exposure on developing primate cerebrum
14	Melyssa	Minto	mminto@rti.org	Tissue-Specific DNA Methylation Signatures of Alcohol Use Disorder in Human Brain
15	Suzanne	Mitchell	mitchesu@ohsu.edu	Lessons learned in creating selected lines for high and low delay discounting
16	Mahesh	Mohan	mmohan@txbiomed.org	Delta-9-Tetrahydrocannabinol:Cannabidiol combination counteracts colonic epithelial and blood-brain barrier dysfunction in SIV-infected rhesus macaques on combination anti-retroviral therapy
17	Kateryna	Murlanova	kmurlano@buffalo.edu	Loss of astrocytic mu opioid receptors exacerbates aversion associated with morphine withdrawal in mice: a role for mitochondrial respiration
18	Randy	Nelson	randy.nelson@hsc.wvu.edu	Light at Night Drives Sex-Specific Increases in Fentanyl Reward-Related Behaviors
19	Abraham	Palmer	aap@ucsd.edu	RATTACA: a new paradigm for examining genetic correlations in outbred rats
20	Rohan	Palmer	Rohan.Palmer@Emory.edu	Conserved Co-expression Signatures of Chronic Alcohol Consumption across Species
21	Clarissa	Parker	cparker@middlebury.edu	Genetic variation and heritability of negative affective withdrawal from cocaine in the CC/DO founder mouse strains
22	Gita	Pathak	gita.pathak@yale.edu	Epigenetic profiles of latent classes for polysubstance use disorder
23	Jack	Pattee	jack.pattee@cuanschutz.edu	Adjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organisms
24	Qian	Peng	qpeng@scripps.edu	Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations
25	Inga	Peter	inga.peter@mssm.edu	High Content Transcriptomics Screen to Explore Pathway Crosstalk between Morphine and Antiretroviral Therapy Drug Combinations
26	Amanda	Gentry	Amanda.Gentry@vcuhealth.org	Machine Learning to Predict Alcohol Consumption From Blood-Based Biomarkers
27	Robert	Phillips	rphill3@uab.edu	Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
28	Bryan	Quach	bquach@rti.org	Transcriptome-wide association study for frequent cocaine use identifies gene dysregulation in CD4+ T cells linked to immune response and cancer pathways
29	Fatir	Qureshi	qureshi@wi.mit.edu	Chromatin QTL analysis identifies genetic variants that influence H3K27ac in opioid overdose cases.
30	Yumna	Rahman	rahmany@vcu.edu	Influence of Genotype and Sex on Oral Nicotine Consumption in Founder Strains of Diversity Outbred Mice
31	Hannah	Ramcharan	hkramcha@wi.mit.edu	Variation in Gene Regulation Across Neurons from Seven Different Brain Regions
32	David	Root	David.Root@Colorado.EDU	Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
33	Adrian	Rothenfluh	adrian.rothenfluh@hsc.utah.edu	Bitter gustatory perception protects Drosophila from escalating cocaine consumption preference.
34	Erick	Saldes	esaldes@miners.utep.edu	Novel genetic loci interacting with social environment for dysfunctional inhibitory control
35	Danielle	Sambo	danielle.sambo@nih.gov	Differential effects of prenatal alcohol exposure on brain growth in a mouse model for fetal alcohol spectrum disorder
36	Yasmine	Sami	yns@wi.mit.edu	Differentially expressed genes in Opioid Use Disorder are enriched amongst genes with brain region specific regulatory activity
37	Jiangwen	Sun	jsun@odu.edu	Training Deep Neural Networks Predicting DNA Methylation to Elucidate Genetic Associations in Substance Use Disorders

May 17 – Poster Session D (2:30 pm – 4:00 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
2	Pietro	Sanna	psanna@scripps.edu	Unraveling the interplay between neuroHIV and substance abuse with systems biology to shed light on novel druggable targets.
3	Katherine	Savell	katherine.savell@nih.gov	Development of multipleXed Population Selection and Enrichment single nuclei RNA-sequencing (XPoSE-seq) to characterize neuronal ensembles in cocaine relapse
4	Randal Alex	Serafini	alex.serafini@icahn.mssm.edu	Novel Oxycodone Paradigm Highlights Mesocorticolimbic Mechanisms Underpinning Withdrawal-associated Behaviors with and without Chronic Pain
5	Marit	Solheim-Witt	marit@alpha-element.com	Resilience, resourcefulness and self-leadership: Evaluation of a self-management program and novel conceptual framework of Vitality Type patterns in behavior and communication
6	Akhil	Sharma	akhilsharma@wayne.edu	Comparing Responses of the Nucleus Accumbens and Ammon’s Horn to Methamphetamine Neurotoxicity
7	Aliaksandra	Sikirzhytskaya	sikirzha@mailbox.sc.edu	AI-based mining of biomedical literature: Applications for the drug repurposing for the treatment of HIV-Associated Neurocognitive Disorder.
8	Omar	Soler-Cedeño	omar.soler-cedeno@nih.gov	Brain CB2 receptor: a new therapeutic target for treating opioid use disorders, major findings from a new CB2-KO-eGFP reporter mouse line
9	Sheetal	Sreeram	sxs2286@case.edu	Induced pluripotent stem cells (iPSCs) derived cerebral organoids to model the impact of methamphetamine exposure on HIV latency.
10	Chaitanya	Srinivasan	csriniv1@cs.cmu.edu	Regulatory variation in D1/D2 co-expressing medium spiny neurons is suggested to predispose addiction-related traits
11	Jerry	Stitzel	stitzel@colorado.edu	QTL Mapping of Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
12	Kyle	Sullivan	sullivanka@ornl.gov	Heroin overdose-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABAergic interneurons and provide insight into cell type-specific regulatory response
13	Jiangwen	Sun	jsun@odu.edu	Annotating Genetic Variants by Training Deep Neural Networks to Predict Multiple Epigenomic Events in Brain via Effective Multi-task Learning
14	Makoto	Taniguchi	Taniguch@musc.edu	A long non-coding enhancer RNA regulates NPAS4 in the NAc to control drug reward-conditioned behavior
15	Lisa	Tarantino	lisat@med.unc.edu	Genetic mapping of initial locomotor sensitivity to cocaine in two divergent Collaborative Cross inbred mouse strains
16	Iris	Titos	iris.titos@utah.edu	Mechanisms of diet modulating experience-dependent amphetamine preference
17	Jill	Turner	Jill.Turner@uky.edu	Phenotyping Individual Differences in Escalation of Fentanyl Self-Administration in Sprague-Dawley Rats.
18	David	Vandenbergh	djv4@psu.edu	Hyper-Variable Number of Tandem Repeats in Intron 8 of the Human Dopamine Transporter Gene (SLC6A3)
19	Arvind	Venkataraman	avenkata@uw.edu	A genome-wide association study of methamphetamine use among people with HIV
20	Thiago	Viola	thiago.wendt.viola@gmail.com	The effects of maternal cocaine use during pregnancy in pediatric epigenetic clocks and methylation risk scores in humans
21	Lu	Wang	lu.wang.lw763@yale.edu	Whole-exome Sequencing Study of Alcohol Use Disorder in 1,668 European Americans and 1,547 African Americans
22	Xu	Wang	xuwang@temple.edu	Activation of Toll-like receptor 3 by poly (I:C) inhibits HIV infection of human iPSC-derived microglia
23	Tao	Wu	Tao.Wu@bcm.edu	Quantitative Profiling of DNA N6-methyladenine at single-base resolution with NAME-Seq
24	Sarah	Neal	sjneal@mdanderson.org	A Baboon Research Resource for Use in Studies on Substance Abuse Disorders
25	Julie	White	jdwhite@rti.org	Integration of DNA methylation and RNA sequencing elucidates differential gene regulation associated with alcohol use disorder in the human brain
26	Anastasia	Williams	awill57@gmu.edu	The effects of cannabidiol and HU308 on viral transcription in HIV-1 infected cells and resulting extracellular vesicle release
27	Caryn	Willis	cdwillis@rti.org	Gene Correlation Networks Replication Analysis Across Studies to Identify Top Candidate Gene Targets in Opioid Use Disorder
28	Michael	Wyatt	wyatt@cop.sc.edu	Drug Repurposing for the prevention of dementia among people living with human immunodeficiency virus: A focus on the renin-angiotensin system
29	Rong-Guang	Xu	roxu@bwh.harvard.edu	How histone post-translational modifications impact nucleosome structure and accessibility: A molecular dynamics study
30	Gal	Yadid	yadidg@mail.biu.ac.il	Use of psychedelic and epigenetic substances as novel approaches for treating substance addiction – hope or hype?
31	Zhenyao	Ye	zye@som.umaryland.edu	Pleiotropic genes for resting-state brain functional connectivity and nicotine addiction
32	Hang	Zhou	hang.zhou@yale.edu	Mendelian Randomization Analysis of the Effects of Alcohol Use on Cancer Risk
33	Yanjiao	Zhou	yazhou@uchc.edu	Genetic control of the microbiome and bile acids to influence addiction-related behaviors
34	Laura	Hack	hack@stanford.edu	Ketamine’s Acute Effects on Negative Brain States are Mediated through Distinct Altered States in Humans
35	Yanchao	Pan	hanyou@umich.edu	A revamped rat reference genome improves the discovery of genetic diversity of laboratory rats

Abstracts From Those Unavailable to Present
First Name	Last Name	Email	Abstract Title
Li-Shiun	Chen	li-shiun@wustl.edu	Roadmap for translating genomic evidence to clinical interventions for prevention and treatment
Ditte	Demontis	ditte@biomed.au.dk	Elucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS
Desmond	Smith	DSmith@mednet.ucla.edu	Cocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice

Past Genetic Meetings are available on the Archives site

April 26, 2023