NIDA Genetic Consortium Meetings & Abstracts

March 2021 Meeting

Welcome

Welcome to the 2021 Genetics and Epigenetics Cross-Cutting Research Team (GECCRT) Meeting! The GECCRT is sponsored by the National Institute on Drug Abuse (NIDA) and has members from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Mental Health (NIMH). Our mission is to develop NIDA’s portfolio of genetic and epigenetic research relevant to substance use disorders and addictive behaviors. The GECCRT coordinates our programs to meet strategic mission research objectives, including development of a workforce to meet current and future needs.

Major Goals of the GECCRT:

  • Support the discovery of gene variants and epigenetic modification associated with substance abuse and dependence.
  • Promote and facilitate the integration of novel genetic/genomic hypotheses, laboratory and statistical methodologies into studies of substance abuse.
  • Ensure training opportunities in addiction genetics for students and post-doctoral fellows.
  • Support the translation of significant reproducible findings in genetics/genomics research into clinical applications.

Meeting Dates and Times

  • Monday, March 8th: - 10:45 a.m. to 5:00 p.m.
  • Tuesday, March 9th  - 10:45 a.m. to 5:00 p.m.
  • Wednesday, March 10th - 10:45 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

Name and Email Abstract Poster Session Talk Session Slack link
Kerry J. Ressler From SNPs and Stress to SUDs: Genetics and Epigenetic mediators of Social Determinants of Health, PTSD, and Substance Use Disorders

Wednesday
2:00 to 3:00

Monday
11:00 AM
Kerry-ressler
Christopher Guevara Parkinson’s disease gene mutation perturbs behavioral and synaptic adaptions to social defeat stress Monday
4:00 to 5:00
Monday
11:15 AM
Guevara
Jean Lud Cadet Increased cannabinoid receptor expression in the hippocampus drives abstinence from compulsive methamphetamine taking Monday
2:00 to 3:00
Monday
11:30 AM
Cadet-Jean-Lud
Shareefa Dalvie Genomic influences on self-reported childhood maltreatment Monday
3:00 to 4:00
Monday
11:45 AM
Dalvie
Randall J. Ellis Genomic prediction of alcohol and opioid use disorders using machine learning Monday
4:00 to 5:00
Monday
1:00 PM
Ellis
Seon-Kyeong Jang Rare variant heritability of tobacco use: Evidence from deep whole-genome sequencing of up to 26,000 individuals Tuesday
2:00 to 3:00
Monday
1:20 PM
Jang
Daniel Jacobson Embracing Complexity: Supercomputing Enabled Systems Biology to Understand Complex Neurosystems Tuesday
2:00 to 3:00
Monday
1:40 PM
Jacobson
Rohan Palmer Computational Drug Discovery for Cocaine and Opioid Use Disorders Wednesday
2:00 to 3:00
Tuesday
11:00 AM
Palmer
Brock Grill Genetic behavioral screen identifies an orphan anti-opioid system Monday
4:00 to 5:00
Tuesday
11:15 AM
brock-grill
Vivek Kumar Discovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) data

Tuesday
3:00 to 4:00

Tuesday
11:30 AM
Kumar
Michelle L. Hastings Antisense Oligonucleotide Approaches to the Treatment of Disease Monday
4:00 to 5:00
Tuesday
11:45 AM
Michelle-hastings
Christiann Gaines Assessing the impact of compositionally distinct gut microbiotas on differences in initial cocaine sensitivity in closely related inbred mouse substrains Monday
4:00 to 5:00
Tuesday
1:00 PM
Gaines
Sierra Simpson Drugs, Bugs, and SUDs: Leveraging the Microbiome and Metabolome to Predict Addiction Liability Wednesday
3:00 to 4:00
Tuesday
1:20 PM
Simpson
Drew Kiraly Manipulations of gut microbiome diversity alter cocaine seeking behavior and striatal gene expression Tuesday
2:00 to 3:00
Tuesday
1:40 PM
kiraly-d
Alexander Urban Technically challenging types of genome sequence variants with relevance to brain function, and new approaches to their analysis Wednesday
3:00 to 4:00
Wednesday
11:00 AM
Urban
Melissa Gymrek The impact of short tandem repeats on complex traits Monday
4:00 to 5:00
Wednesday
11:15 AM
Gymrek
Avindra Nath Epigenetic regulation of retroviruses in embryogenesis, oncogenesis and neurodegeneration Tuesday
4:00 to 5:00
Wednesday
11:30 AM
Nath
Sandhya Chandrasekaran Neuron-specific regulation of chromosomal megadomains in the mammalian brain implicated in endogenous retroviral silencing Monday
3:00 to 4:00
Wednesday
11:45 AM
Chandrasekaran
Jimmy Olusakin Transcriptomic adaptations in emotional and sensory brain nuclei in perinatal fentanyl exposed rodents Tuesday
4:00 to 5:00
Wednesday
4:00 PM
Olusakin
Marta Pratelli Drugs of abuse drive activity producing changes in gene expression that switch neurotransmitters and behaviors Wednesday
2:00 to 3:00
Wednesday
4:20 PM
Pratelli
Jian Feng Neuron-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addiction Monday
4:00 to 5:00
Wednesday
4:40 PM
Feng
Arpana Agrawal An Update from the Psychiatric Genomics Consortium’s Substance Use Disorder Working Group (PGC-SUD) Monday
2:00 to 3:00
  Agrawal
Carter Allen A statistical framework for network-based discovery of opioid use sub-populations in rats using the Bayesian stochastic block model Monday
2:00 to 3:00
  Allen
Robert Anholt The Drosophila Brain on Cocaine at Single Cell Resolution Monday
2:00 to 3:00
  Anholt
Brad Aouizerat Frequent Cocaine Use is Associated with Larger HIV Reservoir Size Quantified by the Intact Proviral DNA Assay Monday
2:00 to 3:00
  Aouizerat
Jared Bagley Impulsivity Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice Monday
2:00 to 3:00
  Bagley
Brandon Baker Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Outbred Populations of Drosophila melanogaster Monday
2:00 to 3:00
  Baker
Amanda Barkley-Levenson Validating novel human GWAS hits for problematic alcohol use and consumption using genetic mouse models Monday
2:00 to 3:00
  Barkley-Levenson
Peter Barr Identifying Shared and Specific Genetic Risks for Substance Use Disorders Monday
2:00 to 3:00
  Barr
Amelie Baud Investigating the gut-brain axis in 4,006 P50 Heterogeneous Stock rats Monday
2:00 to 3:00
  Baud
Yudhishtar Bedi Paternal Alcohol Exposure Leads To Altered Sperm Epigenome And Fetal Growth Restriction Monday
2:00 to 3:00
  Bedi
Jacob Beierle BALB/c substrain differences in whole brain concentrations of the highly potent oxycodone metabolite, oxymorphone map to chromosomes 5, 10, and 16 in a reduced complexity cross Monday
2:00 to 3:00
  Beierle
Andrew Bergen Multiethnic Prediction of Nicotine Biomarkers and Associations with Nicotine Dependence Monday
2:00 to 3:00
  Bergen
Laura Bierut When will we be ready to bring polygenic risk scores into clinical medicine? Monday
2:00 to 3:00
  Bierut
Molly Bogue Mouse Phenome Database: Resources and analysis tools for curated and integrated primary mouse addiction related phenotype data Monday
2:00 to 3:00
  Bogue
Heather Branscome Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage Monday
2:00 to 3:00
  Branscome
Caleb Browne Heroin self-administration and seeking induces transcriptional reprogramming throughout the brain’s reward circuitry Monday
2:00 to 3:00
  Browne
Jason Bubier Genetic variation in opioid-induced respiratory depression Monday
2:00 to 3:00
  Bubier
James Cai Machine Learning Analysis of Single-cell Gene Regulatory Networks Reveals Signature Transcriptional Responses in Neurons to Acute Morphine Treatment Monday
2:00 to 3:00
  Cai
Cali Calarco Mitochondria-Related Nuclear Gene Expression in Reward Related Brain Regions and Blood Mitochondrial Copy Number after Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice Monday
2:00 to 3:00
  Calarco
Rianne Campbell Molecular Profiling of Mouse Ventral Pallidum Projection Neurons Monday
3:00 to 4:00
  Campbell
Nazzareno Cannella Long access heroin self-administration induces grey matter volume reduction in NIH Heterogeneous Stock rats Monday
3:00 to 4:00
  Cannella
Anjelica Cardenas The Functional Role of a Human Polymorphism (rs2304297) in the 3’-UTR of the CHRNA6 Gene in Nicotine-Induced Locomotion and Anxiety in Adolescent Sprague Dawley Rats Monday
3:00 to 4:00
  Cardenas
Diana Carreno Nicotine plus cue-induced reinstatement is enhanced in adolescent Sprague-Dawley rats containing the Human 3’UTR polymorphism (rs2304297) in the alpha(_)6 nicotinic acetylcholine receptor subunit Monday
3:00 to 4:00
  Carreno
Lieselot Carrette Identification of genetic variants that contribute to compulsive cocaine intake in rats Monday
3:00 to 4:00
  Carrette
Andy Chen Massively Parallel Reporter Assay Reveals Functional Impact of 3’-UTR SNPs Associated with Neurological Disorders Monday
3:00 to 4:00
  Chen
Fang Chen Trans-ethnic Transcriptome-wide Association Study for Smoking Addiction in 1.3 Million Individuals Yields Insights into Tobacco Use Biology and Drug Repurposing Monday
3:00 to 4:00
  Chen-f
Li-Shiun Chen Predicting smoking cessation treatment outcomes with genetic risk scores and biomarkers Monday
3:00 to 4:00
  Chen-LiShiun
Shuo Chen Genetic Fine-mapping with Dense Linkage Disequilibrium Blocks: genetics of nicotine dependence Monday
3:00 to 4:00
  Chen-s
Apurva Chitre Exponential increase in QTL detection with increased sample size in heterogeneous stock rats Monday
3:00 to 4:00
  Chitre
Olivia Corradin Hypoacetylated neuronal enhancers in opioid overdoses converge on the regulatory circuit of specific genes Monday
3:00 to 4:00
  Corradin
Caitlin Crook The interplay between cocaine and the feeding hormone leptin in genetically diverse rats Monday
3:00 to 4:00
  Crook
Renata Cupertino Neural correlates of polygenic risk for cannabis use and cannabis use disorder Monday
3:00 to 4:00
  Cupertino
M. Imad Damaj Genetic Variation in nicotine withdrawal in Mice Monday
3:00 to 4:00
  Damaj
Udita Datta Naturally occurring variation in cocaine self-administration among high-diversity mouse populations Monday
3:00 to 4:00
  Datta
Jeremy J. Day The extracellular matrix protein Reelin is enriched in cocaine-activated D1-MSNs and modulates transcriptional responses to dopamine Monday
3:00 to 4:00
  Day
Giordano de Guglielmo Characterizaiton of individual differences in “addiction score” and choice between cocaine versus palatable food choice in Heterogeneous Stock (HS) male and female rats Monday
​​​​​​​3:00 to 4:00
  de Guglielmo
Catherine DeMarino Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release Monday
​​​​​​​3:00 to 4:00
  DeMarino
Marissa Ehringer Differential gene expression responses to oxycodone self-administration in the amygdala and prefrontal cortex of inbred rat strains Monday
​​​​​​​3:00 to 4:00
  Ehringer
Kit K. Elam Functional Polygenic Risk for Aggression Indirectly Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood Monday
4:00 to 5:00
  Elam
Luke Evans Genetic architecture of four smoking behaviors using partitioned SNP heritability Monday
​​​​​​​4:00 to 5:00
  Evans
Delaney Fischer Novel Approach for Cell-Type Specific Profiling of Histone Post-Translational Modifications and Corresponding Gene Expression Monday
​​​​​​​4:00 to 5:00
  Fischer
Megan Fox Fentanyl abstinence causes neuron subtype specific structural and molecular changes in the nucleus accumbens Monday
​​​​​​​4:00 to 5:00
  Fox
Hongyu Gao Single cell analyses of putamen region from subjects with alcohol use disorders Monday
​​​​​​​4:00 to 5:00
  Gao
Jonathan Gewirtz Daily morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female rats Monday
​​​​​​​4:00 to 5:00
  Gewirtz
Michael Golding Epigenetic Toxicity: Preconception Paternal Exposures and the Programming of Offspring Birth Defects Monday
​​​​​​​4:00 to 5:00
  Golding
German Gornalusse Chronic heroin use generates distinct cleavage patterns of tRNA-Gly-GCC in semen Monday
​​​​​​​4:00 to 5:00
  Gornalusse
Rahul Guda Integrated systems analysis of mixed neuroglial cultures proteome post oxycodone exposure: Implications for altered synaptogenesis Monday
​​​​​​​4:00 to 5:00
  Guda
Mustafa Hakan Gunturkun RatsPub: a webservice aided by deep learning to mine PubMed for addiction-related genes Monday
​​​​​​​4:00 to 5:00
  Gunturkun
Megan Hastings Hagenauer Genetic liability for internalizing versus externalizing behavior manifests in the adult hippocampus: A comparison of the results of transcriptional profiling studies performed in eight bred rat models Monday
​​​​​​​4:00 to 5:00
  Hagenauer
Peter Hamilton CREB-mediated activation of Zfp189 and re-engineering ZFP189 within mouse accumbens reveal transcriptional mechanisms governing cocaine-induced neuroadaptations Monday
​​​​​​​4:00 to 5:00
  Hamilton
Alexander Hatoum Genome-wide Association Study of multiple substance use disorders identifies novel loci related to mental and physical health Monday
​​​​​​​4:00 to 5:00
  Hatoum
Jordan Hernandez Double Trouble: Adolescent alcohol exposure in pre and postnatal oxycodone offspring Monday
​​​​​​​4:00 to 5:00
  Hernandez
Alannah Hillmer The genetic contribution of cannabis use in opioid addiction: An investigation into sex differences Tuesday
2:00 to 3:00
  Hillmer
Robert Hitzemann Transcriptional Features Associated with Delay Discounting in HS Rats Tuesday
​​​​​​​2:00 to 3:00
  Hitzemann
An Hoang Epigenomic and machine learning strategies reveal key pathways that distinguish the opioid dependent brain Tuesday
​​​​​​​2:00 to 3:00
  Hoang
Saeedeh Hosseinian A forward genetic screen of ENU-mutagenised zebrafish identifies lines showing deficits in impulse control Tuesday
​​​​​​​2:00 to 3:00
  Hosseinian
Spencer Huggett Genes Identified in Rodent Studies of Alcohol and Nicotine Intake Are Enriched in GWASs of Human Substance Use Tuesday
​​​​​​​2:00 to 3:00
  Huggett
Changhoon Jee Cross-species functional validation of overlapping GWAS candidates between tobacco smoking in human and socially acquired nicotine IVSA in rats Tuesday
​​​​​​​2:00 to 3:00
  Jee-1
Changhoon Jee Neuropeptidergic regulation of Compulsive Seeking behavior in C. elegans Tuesday
​​​​​​​2:00 to 3:00
  Jee-2
Cheng Ji Identification of hepatic off-targets of anti-HIV protease inhibitors involved in organelle stress response and liver injury Tuesday
​​​​​​​2:00 to 3:00
  Ji
Emma Johnson The relationships between cannabis, tobacco, and schizophrenia: a genetically informed perspective Tuesday
​​​​​​​2:00 to 3:00
  Johnson
Eric Otto Johnson Genomic SEM GWAS of Opioid Addiction: Digging into OPRM1 and Beyond Tuesday
​​​​​​​2:00 to 3:00
  Johnson
G Allan Johnson Heritability of imaging phenotypes from combined magnetic resonance and light sheet microscopy Tuesday
​​​​​​​2:00 to 3:00
  Johnson
Yan Jouroukhin Role of astrocyte mitochondria in opioid withdrawal Tuesday
​​​​​​​2:00 to 3:00
  Jouroukhin-1
Yan Jouroukhin Role of astrocyte mu opioid receptors in morphine withdrawal Tuesday
​​​​​​​2:00 to 3:00
  Jouroukhin-2
Marsida Kallupi Characterization of addiction-like behaviors to oxycodone in Heterogenous Stock rats Tuesday
​​​​​​​2:00 to 3:00
  Kallupi
Marcus Kaul Chronic, low dose methamphetamine reveals sexual dimorphism in memory performance impaired by exposure to HIV-1 Tat protein Tuesday
​​​​​​​2:00 to 3:00
  Kaul
Paul Kenny Hedgehog-interacting protein in habenula regulates nicotine intake Tuesday
​​​​​​​2:00 to 3:00
  Kenny
Alena Kozlova Sex and brain region-specific gene expression and imprinting of nicotine sensitization and self-administration in rats inform GWAS findings of human smoking phenotypes Tuesday
​​​​​​​2:00 to 3:00
  Kozlova
Brittany Kuhn Sensation seaking behavior contributes to opioid dependence vulnerability in a sex-dependent manner Tuesday
3:00 to 4:00
  Kuhn
Donald Kuhn Long access heroin self-administration significantly alters gut microbiome diversity, structure and composition Tuesday
​​​​​​​3:00 to 4:00
  Kuhn-d
Adele Leggieri Ankk1 regulates the dopaminergic response mediated by dopamine receptor D2 in zebrafish brain Tuesday
​​​​​​​3:00 to 4:00
  Leggieri
Paige Lemen Molecular and Phenotypic Causes and Networks Linked to Morphine and Naloxone Responses in the BXD Family: Time-Dependent Locomotor Effects Tuesday
​​​​​​​3:00 to 4:00
  Lemen
Mark Anthony Leon-Duque New chemical tools to elucidate the interactomics and the epigenetics of opioid drugs Tuesday
​​​​​​​3:00 to 4:00
  Leon-Duque
Emily Levitt Phenotypic structure of delay discounting in relation to diverse health behaviours in a general community sample of 10,701 adults Tuesday
​​​​​​​3:00 to 4:00
  Levitt
Boyang Li Incorporating local ancestry into methylation quantitative trait loci (meQTL) mapping for tobacco smoking in the African American population Tuesday
​​​​​​​3:00 to 4:00
  Li-B
Michael Li A social genomics perspective on methamphetamine use, HIV, and intimate partner violence Tuesday
​​​​​​​3:00 to 4:00
  Li-m
Zhicheng Lin Genetic basis for substance use exacerbation of COVID-19 Tuesday
​​​​​​​3:00 to 4:00
  Lin
Jyoti Lodha Effects of Social Isolation and Ethanol Drinking on the PFC Transcriptome Tuesday
​​​​​​​3:00 to 4:00
  Lodha
Ryan Logan Transcriptional alterations in opioid use disorder reveal the interplay between neuroinflammation and synaptic remodeling across corticostriatal circuits Tuesday
​​​​​​​3:00 to 4:00
  Logan
Falk Lohoff Prescription opioid use and risk for major depressive disorder: a multivariable Mendelian randomization analysis Tuesday
​​​​​​​3:00 to 4:00
  lohoff
Ryan Lusk The alternative splicing and alternative polyadenylation transcriptional landscape of the HXB/BXH recombinant inbred rat panel and its role in predisposition to voluntary alcohol consumption Tuesday
​​​​​​​3:00 to 4:00
  Lusk
Tianzhou Ma White matter integrity and nicotine dependence in smokers: evaluating vertical and horizontal pleiotropy Tuesday
​​​​​​​3:00 to 4:00
  Ma
Trudy Mackay The Drosophila Brain on Cocaine at Single Cell Resolution Tuesday
​​​​​​​3:00 to 4:00
  Mackay
Katarzyna Macur Comprehensive response of HIV-infected human primary macrophages to methamphetamine exposure Tuesday
​​​​​​​3:00 to 4:00
  Macur
Brion Maher An Examination of Differential Methylation and Gene Expression in Dorsolateral Prefrontal Cortex Following Opioid Overdose Tuesday
​​​​​​​3:00 to 4:00
  Maher
Maria Cecilia Garibaldi Marcondes Detection of H3K4me3 identifies neuroHIV signatures and detects genomic effects of Methamphetamine in addiction pathways in post-mortem HIV+ brain specimens that are not eligible to transcriptome analysis Tuesday
​​​​​​​3:00 to 4:00
  Marcondes
Lisa Maturin The Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administration Tuesday
​​​​​​​3:00 to 4:00
  Maturin
Stephen McGee From the developers of Smokescreen: a booster panel for development of addiction polygenic risk scores Tuesday
​​​​​​​3:00 to 4:00
  McGee
Skyler McShane Positive Relationship between Set-Shifting, Learning Rate and Delay Discounting Tuesday
4:00 to 5:00
  McShane
Aleksandra Mech Identification of lines showing altered sensitivity to rewarding effects of nicotine using a self-administration assay in zebrafish Tuesday
​​​​​​​4:00 to 5:00
  Mech
Emily Mendez Angiogenic Gene Networks are Dysregulated in Postmortem Brain of Opioid Use Disorder Subjects: Evidence from Multi-Omics and Imaging Approaches Tuesday
​​​​​​​4:00 to 5:00
  Mendez
Munise Merteroglu Gene regulatory responses to developmental drug exposures in zebrafish Tuesday
​​​​​​​4:00 to 5:00
  Merteroglu
Philipp Mews Epigenetic Priming Drives Aberrant Gene Expression Linked to Cocaine Relapse Tuesday
​​​​​​​4:00 to 5:00
  Mews
Arojit Mitra Discovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) data Tuesday
​​​​​​​4:00 to 5:00
  Mitra
Swarup Mitra Histone demethylase JMJD3 mediates opioid-induced cellular and behavioral plasticity Tuesday
​​​​​​​4:00 to 5:00
  Mitra
Mahesh Mohan Cannabinoid modulation of the microbiota-gut-brain axis in HIV/SIV infection Tuesday
​​​​​​​4:00 to 5:00
  Mohan
Janitza L. Montalvo-Ortiz Neuronal Methylome and Hydroxymethylome Profiling of Opioid Use Disorder Tuesday
​​​​​​​4:00 to 5:00
  Montalvo-Ortiz
Alyssa Moore Evaluating the stability of measures of motivation and preference in a behavioral economic drug self-administration procedure Tuesday
​​​​​​​4:00 to 5:00
  Moore
Milad Mortazavi Polymorphic SNPs, short tandem repeats and structural variants cause differential gene expression among inbred C57BL/6 and C57BL/10 substrains Tuesday
​​​​​​​4:00 to 5:00
  Mortazavi
Anna Moszczynska The Role of PARKIN in Methamphetamine Use Disorder Tuesday
​​​​​​​4:00 to 5:00
  Moszczynska
Megan Mulligan Rat reduced complexity model of oxycodone self-administration and stress responsiveness Tuesday
​​​​​​​4:00 to 5:00
  Mulligan
Daniel Munro Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research Tuesday
​​​​​​​4:00 to 5:00
  Munro
Elliot C. Nelson Retrospective reports of itching with initial opioid misuse are strongly associated with risk of opioid use disorder (OUD), specific OUD symptoms, and more problematic course Tuesday
​​​​​​​4:00 to 5:00
  Nelson
Jie Ni PeerPub: a novel device for concurrent oral operant conditioning by two rats Tuesday
​​​​​​​4:00 to 5:00
  Ni
Maria Niarchou Identifying the medical phenome of patients with a prescription of buprenorphine in the Electronic Health Record (EHR) and the role of genetic risk Tuesday
​​​​​​​4:00 to 5:00
  Niarchou
Steve Oghumu X chromosome inactivation in sex disparities to substance use disorder Tuesday
​​​​​​​4:00 to 5:00
  Oghumu
Angela Ozburn Nicotine, midazolam, morphine, and methamphetamine intake in High Drinking in the Dark mice Tuesday
​​​​​​​4:00 to 5:00
  Ozburn
Gita Pathak Dissecting polysubstance use disorders via polygenic risk scoring Wednesday
1:00 to 2:00
  Pathak
Jack Pattee Modeling recommendations and simulated power for the analysis of expression quantitative trait loci in the Hybrid Rat Diversity Panel Wednesday
​​​​​​​1:00 to 2:00
  Pattee
McKenzie Pavlich Characterization of addiction-like behaviors to alcohol in Heterogenous Stock rats Wednesday
​​​​​​​1:00 to 2:00
  Pavlich
Robert Phillips An atlas of transcriptionally distinct cell populations within the rat ventral tegmental area Wednesday
​​​​​​​1:00 to 2:00
  Phillips
Tamara J. Phillips-Richards Bidirectional Effects of a Taar1 SNP Conversion on Methamphetamine Traits Wednesday
​​​​​​​1:00 to 2:00
  Phillips-Richards
Amara Plaza-Jennings Cell-type specific genomics and transcriptomics of HIV in the brain Wednesday
​​​​​​​1:00 to 2:00
  Plaza-Jennings
Oksana Polesskaya High-throughput genotyping of HS rats using low-coverage sequencing Wednesday
​​​​​​​1:00 to 2:00
  Polesskaya
Samuel Powell Transcription Factor-Driven Production of Midbrain Dopaminergic Neurons from Human iPS Cells and Psychiatric Disease Risk Modeling Wednesday
​​​​​​​1:00 to 2:00
  Powell
Alex Ramsey Advancing the development of a genetically-informed behavioral intervention to promote tobacco treatment and cessation Wednesday
​​​​​​​1:00 to 2:00
  Ramsey
Benjamin Reiner Transcriptomic characterization of the nucleus accumbens in an animal model of opioid use disorder using single-nuclei RNA sequencing Wednesday
​​​​​​​1:00 to 2:00
  Reiner
Jose Maria Restrepo Expression-based polygenic score derived from corticolimbic DCC gene co-expression networks as a biomarker of SUD risk Wednesday
​​​​​​​1:00 to 2:00
  Restrepo
Pamela Romero Villela A gene-by-gene interaction analysis of rs16969968 and genome-wide loci on cigarettes per day in the UK Biobank Wednesday
​​​​​​​1:00 to 2:00
  Romero Villela
Adrian Rothenfluh Iterative ATAC-seq to home in on specific neuron subsets Wednesday
​​​​​​​1:00 to 2:00
  Rothenfluh
Laura Saba Webinar Series on Quantitative Genetics Tools for Mapping Trait Variation to Mechanisms, Therapeutics, and Interventions Wednesday
​​​​​​​1:00 to 2:00
  Saba
Sandra Sanchez-Roige Genome-wide association study of ‘not as prescribed’ prescription opioid use in 132,113 23andMe research participants Wednesday
​​​​​​​1:00 to 2:00
  Sanchez-Roige
Michael Saul The 5-HT1D receptor modulates volitional cocaine-related behaviors Wednesday
​​​​​​​1:00 to 2:00
  Saul
Gretchen Saunders Trans-ancestry GWAS meta-analysis of tobacco and alcohol use Wednesday
​​​​​​​1:00 to 2:00
  Saunders
Lori Schirle A Novel Data-Driven Approach to Evaluate the Spectrum of Opioid Use in Electronic Health Data Wednesday
2:00 to 3:00
  Schirle
Laurel Seemiller Fear learning deficits after acute ethanol or MK-801 treatment in adolescent and adult C57BL/6J and DBA/2J inbred mice Wednesday
​​​​​​​2:00 to 3:00
  Seemiller
Nancy Sey Elucidating neurobiological processes underlying cigarette smoking and alcohol use traits Wednesday
​​​​​​​2:00 to 3:00
  Sey
Alexander Smith Dorsal Peduncular Prefrontal Cortex contains cells uniquely sensitive to opioids: Relevance to opioid reward and addiction Wednesday
​​​​​​​2:00 to 3:00
  Smith
Jerry Stitzel The Use of Chromosome Substitution Strains to Identify Genetic Modifiers that Alter the Impact of Chrna5 Deletion on Oral Nicotine Intake in Mice Wednesday
​​​​​​​2:00 to 3:00
  Stitzel
Jing Sun Epigenetic age acceleration among person who inject drugs with poorly controlled HIV Wednesday
​​​​​​​2:00 to 3:00
  Sun
Boris Tabakoff Are We Going in Circles: Circular RNA as Another Integral Member of the RNA World? Wednesday
​​​​​​​2:00 to 3:00
  Tabakoff
Yalun Tan Neuron Navigator 1 (Nav1) Regulates Learning, Memory and the Response to Multiple Drugs of Abuse (DOA) Wednesday
​​​​​​​2:00 to 3:00
  Tan
Lisa Tarantino Acute locomotor activation and behavioral sensitization to cocaine in the Collaborative Cross and Diversity Outbred mouse populations Wednesday
​​​​​​​2:00 to 3:00
  Tarantino
Collin Teague Phosphodiesterase 1b is an Upstream Regulator of a Key Gene Network in the Nucleus Accumbens Driving Addiction-Like Behaviors Wednesday
​​​​​​​2:00 to 3:00
  Teague
Samikkannu Thangavel HIV-1 Tat and Cocaine Impact Astrocyte Energy Metabolism: Roles of microRNA in Epigenetic Regulation Wednesday 2:00 to 3:00   Thangavel
Lani Tieu Identification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorder Wednesday
​​​​​​​2:00 to 3:00
  Tieu
Dong-Binh Tran Associations between microbiota and novelty behavior in mice with reference to cocaine addiction Wednesday
​​​​​​​2:00 to 3:00
  Tran
Matthew Tran Single-nucleus transcriptome analysis reveals cell type-specific molecular signatures across reward circuitry in the human brain Wednesday
​​​​​​​2:00 to 3:00
  Tran-n
Mudit Tyagi Cocaine-induced NFAT, NF-kB and AP-1 cooperate in facilitating HIV gene expression and replication Wednesday
​​​​​​​2:00 to 3:00
  Tyagi
Mallory Udell TailTimer: automating data collection for the rodent tail immersion assay Wednesday
​​​​​​​2:00 to 3:00
  Udell
Hemayet Ullah Host Targeted Antivirals Inhibit RACK1 mediated IRES Activities in HIV-1 Wednesday
​​​​​​​2:00 to 3:00
  Ullah
Denong Wang Modulating ADAR-1 arm of innate immunity for HIV cure Wednesday
​​​​​​​2:00 to 3:00
  Wang-d
Meiyue Wang Does Population Structure Affect Murine Genome-Wide Association Study (GWAS) Results? Wednesday
​​​​​​​2:00 to 3:00
  Wang-m
Qun Wang Organoids as New Platform to Study Substance Use Disorders Wednesday
3:00 to 4:00
  Wang-q
Tengfei Wang GWAS on socially acquired nicotine IVSA in heterogeneous stock rats highlights genes implicated in human smoking behavior Wednesday
​​​​​​​3:00 to 4:00
  Wang-t
Xingyan Wang Near Optimal Trans-ethnic Meta-Analysis of Smoking Phenotypes in 1.3 Million Individuals Wednesday
​​​​​​​3:00 to 4:00
  Wang-x
Xusheng Wang Genetic Architecture of Protein Expression in Rat Brain Wednesday
​​​​​​​3:00 to 4:00
  Wang-xusheng
Brenna Williams Genome-wide association study of psychostimulant-induced behavior in Drosophila melanogaster Wednesday
​​​​​​​3:00 to 4:00
  Williams-b
Jin Xu Characterization of an exon 7-associated seven transmembrane C-terminal variant, mMOR-1O, of the mu opioid receptor gene (Oprm1) in a conditional gene targeting mouse model Wednesday
​​​​​​​3:00 to 4:00
  Xu-jin
An Ye Lineage Tracing of Human Exosomal microRNAs to Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response Wednesday
​​​​​​​3:00 to 4:00
  Ye-an
Fengchun Ye Regulation of HIV Silencing by Nuclear Receptors Wednesday
​​​​​​​3:00 to 4:00
  ye-fengchun
Szu-Ying (Sam) Yeh The Role of ∆FosB in the Development of Drug Addiction: Identifying ∆FosB Transcriptional Targets in Nucleus Accumbens Wednesday
​​​​​​​3:00 to 4:00
  Yeh-Sam
Elizabeth Yen The role of sex and inflammation on the developing brain in neonatal abstinence syndrome (NAS) Wednesday
​​​​​​​3:00 to 4:00
  Yen-elizabeth
Dana Zeid Behavioral and genetic characterization of contextual fear conditioning and related phenotypes using the BxD RI panel Wednesday
​​​​​​​3:00 to 4:00
  Zeid
Jun-Jie Zhang High-throughput identification of functional variants in gene enhancers associated with alcohol use disorder Wednesday
​​​​​​​3:00 to 4:00
  Zhang-jun-jie
Xinyu Zhang Deconvolution of bulk DNA methylome and a cell type specific epigenome-wide association study for HIV infection Wednesday
​​​​​​​3:00 to 4:00
  Zhang-xinyu
Jessica Zhou Cell type-specific multiomic analysis of substance use disorders in outbred rats Wednesday
​​​​​​​3:00 to 4:00
  Zhou-jessica
Xiaoxi Zhuang N6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to Cocaine Wednesday
​​​​​​​3:00 to 4:00
  Zhuang-Xiaoxi
Katerina Zorina-Lichtenwalter Shared genetic risk factors in pain conditions Wednesday
​​​​​​​3:00 to 4:00
  Zorina-Lichtenwalter
Elizabeth Zuniga-Sanchez Illuminating the molecular mechanisms of drug-induced neuroplasticity using the mouse retina Wednesday
​​​​​​​3:00 to 4:00
  Zuniga-Sanchez

 

Abstracts and Agenda from January 2020 meeting

Agenda and Meeting Abstracts

Submitter Title of Abstract Session #
Agrawal Findings from the Substance Use Disorders Working Group of the Psychiatric Genetics Consortium 4 T11
Akbarian A Chromosomal Connectome for Psychiatric and Metabolic Risk Variants in Adult Dopaminergic Neurons C 1
Bacanu Imputation of summary statistics using large reference panels increases the accuracy and resolution of genetic signals coming from metanalysis of substance use disorder C 2
Bachtell Phenotypic differences in oxycodone responses in the inbred rat strains C 3
Bagley Sex Chromosome Complement Influences Voluntary Ethanol Consumption in Adolescent Mice C 4
Bailey Heritable variation and genetic correlation of addiction-related phenotypes in the CC/DO recombinant inbred mouse panel C 5
Baker Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogaster C 6
Baker Single-cell transcriptional responses to cocaine exposure in the Drosophila brain C 7
Bandrowski Addicted to FAIR data? The role of repositories and reproducibility in improving impact of data in addiction research. 6 T14
Bangasser Sex differences in stress inoculation of addiction-like phenotypes C 8
Barr Prediction of alcohol and other substance use disorders using a polygenic score for broader externalizing risk. C 9
Barry Modeling nicotine and smoking exposures in the developing brain C 10
Beierle Nearly isogenic BALB/cJ and BALB/cByJ substrains differ in opioid state dependent learning, spontaneous withdrawal, and weight loss in response to oxycodone: Planning a reduced complexity cross. C 11
Belancio Custom RNA-Seq methods identify tissue- and age-specific patterns of retrotransposon expression in vivo 7 T18
Berrettini Neonatal Opioid Withdrawal Syndrome: Observations in a Health System C 12
Bidlack Fibroblast Growth Factor 21 Attenuates Morphine-induced Preference, Tolerance, and Dependence Without Affecting Analgesia C 13
Bogue New tools to assess research replicability using the Mouse Phenome Database C 14
Borrelli Neonatal morphine administration (P1-14) in outbred CFW mice induces enhanced behavioral signs of withdrawal in females and a distinct brainstem transcriptomic profile compared to males C 15
Branscome Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair C 16
Brieño-Enríquez Reproductive decline and epigenetic effects of in utero opioid exposure C 17
Browne Transcriptional reprogramming of the brain reward system by heroin self-administration C 18
Bubier The Microbial community dynamics of cocaine sensitization in two behaviorally divergent Collaborative Cross strains. C 19
Buck Developmental nicotine exposure elicits multigenerational epigenetic anomalies in the frontal cortices, striata, and hippocampi of adolescent mice which co-occur with neurodevelopmental disorder-like phenotypes C 20
Cadet Mimicking methamphetamine use disorder with footshock punishment: epigenetic and transcriptional consequences in the rat brain. 9 T24
Calarco The effect of developmental fentanyl exposure on mitochondrial gene expression in the brain and blood in C57Bl/6 mice 9 T27
Calipari Divergent molecular adaptations in the nucleus accumbens control cocaine reinforcement in males and females 3 T7
Cates Using published datasets to study the role of lncRNA in substance use disorders C 21
Chakraborty Genome to Phenome Implications of Social Stress-Induced Nicotine Preference: A Conspecific Aggressor-Induced Social Stress Model Integrated with a Nicotine Two-Bottle Choice Paradigm C 22
Chandra Egr3 regulates mitochondrial nuclear gene expression in nucleus accumbens neuron subtypes after cocaine exposure C 23
Chen Deep learning model using network topology of linkage disequilibrium patterns increases the accuracy of polygenic risk scores for smoking C 24
Chesler Interpreting human genetics of SUD using multi-species heterogeneous functional genomics data 6 T15
Chevalier Characterizing the HIV-1 Proviral Reservoir in ART-treated Opioid Users C 25
Choi Optically Induced CRISPR Tool for Epigenome Editing in Cocaine Action C 27
Choquet Heritability Estimate of Postoperative Total Morphine Equivalents in New Persistent Opioid Users C 28
Ciborowski Investigation of Macrophage proteome exposed to methamphetamine: A Multiple Reaction Monitoring (MRM) approach C 29
Cowen Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release C 30
Crist Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1 D 1
Damaj Genetic Variation in nicotine withdrawal in Mice D 2
Datta Cocaine self-administration profiles in the Founder Strains of the Collaborative Cross D 3
Day A dopamine-induced gene expression signature regulates neuronal function and cocaine response 3 T9
de Jong Towards an infinite genetic map for the rat hybrid diversity panel D 4
Demontis The polygenic risk for cannabis initiation and cannabis use disorder in individuals with cannabis and multiple drug use disorders and comorbid psychiatric disorders 2 T3
Dick Using the genetic architecture of substance use disorders to aid in gene identification: Findings from the Externalizing Consortium 8 T21
Donaldson Predicting Risk of Opioid Addiction: Evaluation of Genetic Factors Using Machine Learning Algorithms D 5
Dracheva Extensive cell type-specific epigenetic reorganization of the OPRM1 locus in primate evolution D 6
Edenberg Updates from the Psychiatric Genetics Consortium on Alcohol Use Disorders 4 T10
Ehringer The role of a priori-identified addiction and smoking gene sets in smoking behaviors D 7
Elam Genotype-Environment Correlation by Intervention Effects Underlying Middle Childhood Peer Rejection and Associations with Adolescent Marijuana Use D 8
Engeln Transcriptional adaptations in the ventral pallidum following cocaine self-administration D 9
Evans Investigating Genetic Susceptibility to Tobacco Smoking at rs16969968 based on Age at Onset of Regular Smoking D 10
Feng Neuron subtype specific role of DNA methylcytosine dioxygenase TET1 in cocaine addiction D 11
Flores The DCC gene network in the prefrontal cortex and striatum as a predictor of cognitive control and psychopathology C 26
Fowler Nicotine Mediates Extracellular Vesicle RNA Signaling in the Brain 3 T8
Fox Neuron subtype specific structural and molecular changes following fentanyl abstinence D 12
Gaines Identification of a genetic locus and environmental factors influencing initial cocaine sensitivity in C3H substrains D 13
Ganesh Who dare-not smoke-pot – Can schizophrenia polygenic risk predict acute psychotic response to cannabis? D 14
Goldberg Systems Genetic Analysis of Nicotine Withdrawal Deficits in Learning Using the BxD Genetic Reference Panel D 15
Haas Genome-wide association studies of substance use in people living with HIV across the US D 16
Hagenauer A Meta-Analysis of Hippocampal Transcriptional Profiling Studies in a Selectively-Bred Rat Model Converges with Genetic Sequencing to Implicate Specific Candidate Genes and Pathways in the Liability for Internalizing 8 T22
Han Unbiased genetic screen identifies the novel molecules critical for inhibitory control D 17
Hatoum Polygenic Risk Scores for Commonly Used Substances Predict Brain Structural differences in Drug Naïve Children D 18
Hazel Epigenetic variation in neurons from multiple brain regions D 19
Jacobson Digging Deeper: Tackling the Complexity of Genetics and Molecular Mechanisms for Addiction in Human and Model Organism Populations 6 T17
Jee Genetic basis of Nicotine seeking behaviors in C. elegans D 20
Johnson Measures of consumption versus disordered substance use: evidence of different genetic architectures 2 T6
Johnson NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – The Endgame for Wave 1. 4 T12
Kallupi Characterization of addiction-like behaviors to cocaine in Heterogenous Stock rats: Identification of two populations of resistant and vulnerable rats D 21
Kapoor Integrative analysis of omics summary statistics to identify genes associated with substance use disorders D 22
Karam The genetic basis of natural variation in amphetamine sensitivity in Drosophila D 23
Kaul Calbindin- and parvalbumin-positive neurons and microglia display sexual dimorphism in long-term responses to methamphetamine and HIV-associated brain injury D 24
Kim High-Throughput Screening of Circadian Rhythms and Strain-Dependent Relationships with Cocaine Addiction in Genetically Diverse Mouse Populations D 25
Kozlova Understanding the molecular basis of nicotine addiction by integrative functional genomic analyses in a rat model and hiPSC-derived DA neurons D 26
Kuhn Individual variation in addiction-related behaviors contributes to opioid dependence vulnerability D 27
Kumar Forward genetic ENU mutagenesis screen in mice identifies SrGAP3 as a regulator of cocaine responses D 28
Kumar Kockout Mouse Project (KOMP2) has a discovery engine for novel addiction genes D 29
Liao The International Complex Disease Alliance 5 T13
Lin Dopaminergic Epistasis: Substance Use Disorders vs. Parkinson's Disease D 30
Logan Transcriptional signatures in the human postmortem brain reveal associations between molecular rhythm disruptions and opioid use disorder A 1
Lu Transferring the Knowledge between Different Populations and Species by Using a Functional Deep Neural Network A 2
Mathis Septal inputs to habenula regulate nicotine craving 9 T26
Maturin The Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administration A 3
Mews Epigenetic priming underlies transcriptional disruption linked to cocaine relapse A 4
Meyers Association of Polygenic Liability for Cannabis Initiation and EEG Connectivity in Adolescence and Young Adulthood A 5
Miao Integrative analysis of epigenetic response to Methamphetamine overdose in rat brain A 6
Mitchell Lumping splitting and evolving: Strategies to characterize behavioral phenotypes associated with substance use A 7
Mohan Long term delta-9-tetrahydrocannabinol administration inhibits neuroinflammation in chronically SIV-infected rhesus macaques through regulating interferon responses and miRNA mediated pathways A 8
Moszczynska LINE-1 on the Move: A Report on Regional Differences in Brain LINE-1 Activity after Chronic Methamphetamine Administration A 9
Mummidi RNA binding protein HuR regulates CCL2 allelic expression imbalance A 10
Nadeau Phenotypic Noise, the missing dimension of phenotypic variation and disease risk A 11
Neale Multilevel Causal Genetic Modeling in the ABCD Dataset A 12
Nelson A GWAS of Opioid Withdrawal Symptom Clusters A 13
Odegaard Transgenerational epigenetic inheritance associated with prescription opioids abuse: Like mother, like child? A 14
Palmer Shared Sources of Genetic Variation Underlying the Transmissible Liability Index for Substance Use Disorders and Subsequent Cannabis Use A 15
Palmer Multi-trait Polygenic Prediction of Nicotine and Alcohol Dependence A 16
Palmer Comparative Neuro-Transcriptomics of Alcohol Use and Dependence A 17
Palmer All of us for rats: multiomic studies of addiction-related traits in outbred rats A 18
Pan Mu opioid-induced biased signaling through mu opioid receptor seven transmembrane full-length C-terminal splice variants A 19
Parker Measuring negative affective withdrawal in CFW mice: Implications for GWAS A 20
Pathak Genetic association of phenotypic typologies of polysubstance use disorders: A latent class approach A 21
Payer Alu retrotransposon: A common structural variant that can regulate transcript level and structure leading to disease risk 7 T19
Peltz Computational Genetic Analysis of 8300 Biomedical Phenotypes and of Responses to Drugs of Abuse A 22
Periyasamy HIV Tat and morphine-mediated activation of astrocytes: Epigenetic involvement of NLRP6 inflammasome in HAND A 23
Peterson Representation of diverse populations in addiction genetics: a call to action. A 24
Pfenning Addiction-associated genetic variants implicate cell type- and region-specific cis-regulatory elements in addiction neurobiology 9 T25
Philip Genetic correlations and quantitative trait locus mapping reveals shared and unique mechanisms underlying addiction predisposing novelty response traits A 25
Polimanti Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium 2 T5
Quach Smoking-dependent expression QTL evidence in human nucleus accumbens among variants identified by the GSCAN consortium A 26
Ramsey Design and preliminary test of a personalized genetic risk tool to promote smoking cessation A 27
Reiner L1 Retrotransposons in Psychiatric and Substance Use Disorders 7 T20
Reynolds Integrative cross-species analysis uncovers convergent genomic regulatory features associated with complex disease A 28
Rice SmokeScreen: A GWAS resource for Substance Abuse A 29
Richards Reduced Intake When Drugs Make You Cold A 30
Rogers Validation of a Large-Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease Progression Using Visual Statistical Inference B 1
Rothenfluh Mechanisms of cocaine aversion in Drosophila B 2
Ruan Striatal transcriptome-wide profiling of hnRNP H RNA-binding targets via CLIP-seq in response to methamphetamine identifies Oprk1 as a potential translational target underlying reduced behavior in Hnrnph1 mutant mice B 3
Rutherford Recovery Vital Signs 1 T1
Saba Genetic differences in estrous cycle effects on the rat brain transcriptome B 4
Salvatore Social genetic effects for alcohol use disorder B 5
Sanchez-Roige Alcohol consumption and misuse have a distinct genetic basis 2 T2
Schoenrock Genetic dissection of initial drug sensitivity and behavioral sensitization using the Collaborative Cross and Diversity Outbred mouse populations B 6
Sedighim HS rats with high addiction-like behaviors choose cocaine over palatable food in a discrete choice test B 7
Seemiller Nicotine Metabolism Genetics in C57BL/6J and NOD/ShiLtJ mouse strains B 8
Shtutman Drugs repurposing for the treatment of HIV-Associated Neurocognitive Disorder by AI-based literature mining B 9
Sumner The Internal Exposome, Opium Use, and Opioid Use Disorder 2 T4
Telese Cell-type specific gene expression changes associated with adolescence exposure to THC in mice B 10
Telese Sequencing newly initiated transcripts to study transcriptional regulatory mechanisms in substance use disorders B 11
Thangavel Epigenetic Modification of Mitochondrial DNA in the Development of NeuroAIDS B 12
Troiani Validation of a DSM-5 OUD severity score derived from health record review B 13
Troiani Measuring Quantitative Traits of Alcohol Use Disorder in an Integrated Health System B 14
Tyagi Cocaine promotes HIV gene expression and replication by co-stimulating NFAT, NF-kB and AP-1, as major transcription factors. B 15
Vassileva Associations of polygenic risk scores with neurocognitive and psychiatric phenotypes in Bulgarian substance users B 16
Verhulst Analyzing latent propensities to addictive behaviors in a multivariate GWAS framework using GW-SEM. 8 T23
Walker Adolescent Stress Results in Sex-Specific Reprogramming of the Reward Circuitry Transcriptome in Adulthood B 17
Walss-Bass Demyelination and Accelerated Aging as Mechanisms of Cocaine-induced Neurotoxicity B 18
Weinstock Influence of the microbiome on novelty behavior and cocaine addiction in mouse models. B 19
Weiss Successful Illumina Array Genotyping on Serum Stored For Three Decades B 20
Williams Genome-wide association study of psychostimulant-induced behavior in Drosophila melanogaster B 21
Wimmer Transcriptomics associated with opioid craving in the nucleus accumbens of male and females Long Evans rats B 22
Wolstenholme Adolescent binge ethanol slows oligodendrocyte maturation through regulation of histone methylation in the PFC B 23
Won Elucidating the neurobiological bases of cigarette smoking and nicotine dependence 6 T16
Yadid PLX-PAD placental derived mesenchymal like adherent stromal cells as an effective cell therapy for cocaine addiction in a rat model B 24
Zhang In silico Epitope Mining and the Search for a Universal Carrier Protein B 25
Zhang An Efficient Method for Global Gene Regulatory Network Construction B 26
Zhang Epigenome-wide DNA Methylation Profiling: Methylation Capture Bisulfite Sequencing versus Infinium MethylationEPIC BeadChip B 27
Zhang MicroRNAs regulate the transgenerational impact of nicotine exposure and smoking B 28
Zhong Alcohol-induced histone H3 phosphorylation modulates deregulation of Brf1 and tRNA genes in hepatocellular carcinoma B 29
Zlebnik Cannabinoid exposure in adolescence dysregulates genes that orchestrate dopamine development and alters cocaine-motivated behavior B 30

Abstracts and Agenda from January 2019 meeting

Agenda

Abstracts

Submitter Title of Abstract Session #
Arpana Agrawai Updates from the Psychiatric Genomics Consortium's Substance Use Disorders Working Group 5 T11
Schahram Akbarian Epigenome Profiling in Prefrontal Cortex Neurons Exposed to Opiates 4 T9
David Alvarez-Carbonell Virus on the brain: Inflammation and cross-talk between microglia and neurons regulate HIV latency D 40
Robert Anholt Genetic Variation in Alcohol Induced Modulation of Drosophila snoRNAs D 39
Venkata Atluri Magneto electric nanoparticle based CRISPR-Cas9/gRNA delivery to eradicate latent HIV infection and neuropathology in the brain D 38
Silviu-Alin Bacanu Novel pathway transcriptomics method greatly increases detection of molecular pathways associated with substance use disorder D 36
Silviu-Alin Bacanu Direct imputation of summary statistics using large reference panels increases the resolution of genetic signals coming from metanalysis of substance use disorder D 37
Jared Bagley Heritable variation in voluntary alcohol drinking and blood ethanol concentrations in a genetically diverse inbred mouse panel D 35
Brandon Baker Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogaster D 34
James Baurley Prediction of nicotine biomarkers from genotypes D 33
Jacob Beierle Mouse inbred strain survey of oxycodone addiction traits in an opioid multi-stage addiction assessment protocol D 32
Chelsie Benca-Bachman Cross-Species Prioritization of Genomic Loci for Nicotine Consumption 9 T15
Andrew Bergen Biosignatures of Opioid Addiction Treatment Success (BOATS) D 31
Wade Berrettini Electronic Health Records in Evaluating the Potential for Opioid Use Disorder 2 T4
Jinbo Bi Inferring Phenotypes from Substance Use via Collaborative Matrix Completion D 30
Jean Bidlack    Fibroblast Growth Factor 21 Attenuates the Preference for Morphine in a Conditioned Place Preference Assay D 29
Stephanie Bielas Genetic regulation of personalized opioid response in cerebral organoids D 28
Molly Bogue Mouse Phenome Database 2.0: New tools and data resources for curated and integrated primary mouse phenotype data D 27
Kristyn Borrelli Reward sensitivity in Hnrnph1+/- mice following acute methamphetamine administration as measured via intracranial self-stimulation D 26
Caroline Brennan Population based forward genetic screen of mutagenized zebrafish identifies loci associated with nicotine preference and human smoking behavior D 25
Camron Bryant Gene mapping and editing of an intronic variant in Gabra2 in methamphetamine sensitivity and naloxone-induced aversion behaviors in a reduced complexity cross D 24
Jason Bubeir Genetic Variation in Opioid Induced Respiratory Depression in Mice D 23
Matthew Buczynski Enhanced nicotine reward in a mouse model of the P129T FAAH gene polymorphism D 22
Hannah Cates Revealing the chromatin-bound long noncoding RNA landscape of the brain D 21
Marta Ceko Predicting placebo analgesia - literature review and new perspectives D 20
Ramesh Chandra Cocaine-induced histone methylation on Egr3 and Nab2 promoters D 19
Renchao Chen Transcriptome and functional characterization of nucleus accumbens neurons reveal Tac2+ D1 neurons in regulating psychostimulant effect of cocaine D 17
Hao Chen Intermittent oral oxycodone self-administration in inbred strains of rats is heritable D 18
Shuo Chen Large-scale mediation analysis to identify gene-brain network-nicotine addiction pathways using imaging-genetics data 6 T16
Vidya Chidambaran Biopsychosocial clusters based on genetic risk scores for chronic post-surgical pain in children undergoing spine fusion A 42
Hélène Choquet Genetic Ancestry and Tobacco Smoking Behavior D 16
Pawel Ciborowski Secreted metabolome of methamphetamine treated human primary macrophages D 15
Olivia Corradin Identifying pathogenic cell type of disease associated variants B 39
M. Imad Damaj A comparative phenotypic analysis of nicotine pharmacological effects and dependence behaviors in C57BL/6J and C57BL/6N mouse strains D 13
M. Imad Damaj Strain-Dependent Oral Nicotine Intake Using a Free-Choice Paradigm in Mice D 14
Michael Dapp Impact of HIV and Methamphetamine Use on the Nucleome in Individuals on Antiretroviral Therapy D 12
Prasun Datta Modulation of glutamate transporter, EAAT2 expression by epigenome editing. D 11
Giordano de Guglielmo Nociceptin/orphanin FQ reverses the escalation of oxycodone self-administration by normalizing GABA transmission in the amygdala in rats with high addiction-like behaviors D 10
Catherine DeMarino Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release D 9
Price Dickson Systems genetics discovery of genetic, genomic, and gene-by-environment mechanisms driving substance use and sensation seeking D 8
Stella Dracheva The role for DNA (hydroxy)methylation in epigenetic regulation of different brain cell types 4 T8
Jubao Duan Understanding the molecular basis of nicotine addiction by integrative genomic analyses in a rat model and hiPSC-derived DA neurons D 7
Howard Edenberg Update from the Psychiatric Genomics Consortium: Alcohol 5 T12
Marissa Ehringer Inbred Mouse Strains Selected for High and Low Open Field Activity Also Show Differences in Alcohol-Related Behaviors D 6
Kit Elam Using Gene Set Enrichment Analysis to Create Polygenic Risk Scores for Childhood Aggression: A Developmental Examination D 5
Nazira El-Hage Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone modifying enzymes in HIV-infected astrocytes D 4
Michel Engeln Transcriptional adaptations in the ventral pallidum following cocaine self-administration. D 3
Dan Fabris Exploring the CNS Epitranscriptome by MS-Based Approaches D 2
Jian Feng Neuron subtype-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addiction D 1
Abdelali Filali-Mouhim Non-coding RNAs drive increased fatty acid synthesis and reduce inflammation in cART treated HIV infected cocaine users C 42
Hannah Frye CNIH3 expression in female mice modulates hippocampal synapse stability and AMPAR-dependent memory and learning  C 41
Suhas Ganesh Molecular intersections of cannabis exposure and psychosis expression using patient derived HiPSC neurons C 40
Hugh Garavan ENIGMA-Addiction: Gene-brain associations with SUD C 39
Olivier George The Oxycodone Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of oxycodone self-administration C 38
Jonathan Gewirtz Withdrawal-induced anhedonia as a protective factor in opioid addiction C 37
Reza Ghanbari An Untargeted NMR‐based Metabolomics Analysis to Investigate the Urinary Metabolites in Opium Users C 36
Nathan Gillespie GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia C 35
Lisa Goldberg Identification of a Locus on Chromosome Four Mediating Nicotine Withdrawal Deficits in Hippocampal Learning C 34
Judy Grisel Ex-Differences in Drug Sensitivity: Gonads or Non-coding RNAs? C 33
Purnima Gupta Magnetically guided non-invasive nanoformulations of Cas9/gRNA complemented with Opioid antagonist: A novel approach targeting HIV reservoirs in the brain 7 T17
F. Kent Hamra Knockin Rat Model Production by Germline Gene Targeting in Sperm Stem Cells C 32
Kyung-An Han Impulsive flies shed light on new players for dysfunctional inhibitory control C 31
Dana Hancock Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers C 30
Elizabeth Heller Chromatin-directed alternative splicing in brain reward regions 7 T19
Chad Highfill Genetics of Cocaine and Methamphetamine Consumption and Preference in Drosophila melanogaster C 29
Terry Hinds E-cigarette nicotine exposure increases hepatic fat content reducing liver-derived fuel for the brain C 28
William Hoffman Trace Amine Associated Receptor 1 (TAAR1) SNP rs8192620 is associated with increased craving and altered striatal functional connectivity in methamphetamine use disorder (MUD) C 27
Rebecca Hofford The gut microbiome as a homeostatic regulator of striatal gene expression in response to opioids C 26
Mingi Hong Gene-environment interactions in holoprosencephaly C 25
Goku Hu Extracellular Vesicle-mediated small RNA delivery into the CNS C 24
Jun Huang The histone methyltransferase EZH2 primes the differentiation of follicular helper T cells during acute viral infection C 23
Jordan Hughey Fine Mapping Causal Variants of Smoking and Drinking Addiction Related Traits C 22
Ovidiu Iancu Network Approaches Identify Brain Regions and Gene Hubs Associated with Genetic Predisposition for Methamphetamine Intake B 10
Hae Kyung Im Exploring the mechanism behind drug addiction integrating predicted transcriptomic and radiomic data C 20
Changhoon Jee Compulsive behaviors in C. elegans as a model to study Substance Use Disorders C 19
Emma Johnson Large genome-wide association study of cannabis abuse and dependence: an update from the PGC Substance Use Disorders working group C 18
Eric Johnson NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – An Update. 5 T13
Marsida Kallupi Pharmacological treatments for opioid dependence in Heterogeneous Stock rats C 17
Helen Kamens Adolescent social stress influences later ethanol and nicotine behaviors and microRNA expression C 16
Jaakko Kaprio A Genome-wide association meta-analysis of the nicotine metabolite ratio and five other smoking related traits in smokers of European descent C 15
Caline Karam Flying high: Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model C 14
Marcus Kaul Neurotransmission-related gene expression reveals sexual dimorphism in long-term effects of methamphetamine and HIV-associated brain injury C 13
Pamela Kennedy Epigenetic mechanisms mediating cocaine-induced shifts from hippocampal to dorsolateral striatal behavioral learning and control C 12
Paul Kenny Habenular Tcf7l2 links nicotine addiction to diabetes 2 T13
Srivatsan Kidambi METH elicits dose- and time-dependent autophagic cytotoxicity in primary astrocytes C 11
Sam-Moon Kim Strain Differences of Molecular Circadian Rhythms in Primary Fibroblasts Derived from Founders of Collaborative Cross and Diversity Outbred Mice C 10
Zachary Klase Drugs of abuse as drivers of epigenetic change in HIV-1 infection C 9
Albert Ksinan Externalizing and Internalizing Genetic Pathways to Alcohol Consumption and Alcohol Use Disorder Symptoms in College Students C 8
Vivek Kumar Integrated analysis of JAX-KOMP2 data reveals a cluster of genes predictive of addiction phenotypes. C 7
Meena Kumari Do exosomes hold the key to genetic and epigenetic modifications in drug addiction? C 6
Tuuli Lappalainen Functional variation in the human genome: lessons from the transcriptome 3 T5
Casey Lardner Elucidating the cell type-specific transcriptional patterns differentiating stimulant versus opiate addiction C 5
Kaycie Lawson Methamphetamine alters innate immune signaling by inducing an IL-1β-miR-146a negative feedback loop and contributes to anti-retroviral drug resistance in CD4+ T-cells C 4
Jun Li Genetics of Novelty Seeking and Propensity for Drug Abuse in Outbred Rats C 2
Yanchun Li The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory C 3
Xiaoyu Liang DNA methylation signature of Phosphatidylethanol Predicts Hazardous Alcohol Use C 1
Yunlong Liu Alcohol Abuse Associated Allele Specific Expression and Regulation in Human Brain Tissue B 41
Dajiang Liu Phenotype imputation integrating GWAS summary association statistics, deeply phenotyped cohorts and large biobanks Identifies novel loci for cotinine levels B 42
Jingyu Liu Opposite Epigenetic Modifications between Alcohol Use and Exercise Intervention B 40
Qing Lu A Kernel-Based Neural Network for High-dimensional Risk Prediction on Massive Genetic Data B 38
Rui Luo Transgenerational Effect of Smoking During Pregnancy on DNA Methylation of the Newborn B 37
Morteza Mahmoudi Development of Innovative Protein Corona Nanosystem Technology for Early Detection of Substance Abuse Disorders B 36
Travis Mallard Insights into the multivariate genetic architecture of externalizing spectrum behaviors and disorders: Preliminary results from the Externalizing Consortium B 35
Aimee Manzoni-D'Arpino A Parent’s Perspective: Personal Stories of Substance Use Disorder 1 T1
Maria Marcondes Stable histone modifications in post-mortem brain tissue can help overcome quality issues to help identify neuroHIV signatures B 34
Christina Markunas Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use. B 33
Lisa Maturin The Cocaine Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine self-administration B 32
Paul McLaren Polygenic analysis of genome-wide genotype data reveals genetic overlap between HIV acquisition and addiction traits B 31
Raghu Metpally Genomic analyses of prescription opioid dose in chronic opioid exposure B 30
Philipp Mews Epigenetic priming underlies transcriptional dysregulation in cocaine addiction 4 T10
Jacquelyn Meyers Polygenic Influences on Alcohol Related Neurophysiological and Neurocognitive Processes across the Lifespan B 29
Michael Miles Genetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) Mice B 28
Mahesh Mohan Long noncoding RNA landscape in the intestinal epithelium of delta-9-tetrahydrocannabinol treated chronically SIV-infected rhesus macaques B 27
Kevin Morris Recombinant protein guided activation of HIV; a means for target specific purging of proviral reservoirs in the brain B 26
Megan Mulligan Identification of Sex, Strain, and Entourage Effects in the Behavioral and Physiological Response to Cannabinoids B 25
Joe Nadeau The mean-ness of noisy biological systems B 24
Michael Neale Effects of Age, Sex and Race on Substance Abuse and Dependence Assessments B 23
Elliot Nelson A GWAS of Opioid Withdrawal Symptom Count B 22
Katherine Odegaard Transgenerational transcriptomic changes associated with prescription opioids abuse: How far has the apple fallen from the tree? B 21
Abraham Palmer Center for genetic studies of drug abuse in outbred rats B 20
Rohan Palmer Cross-Species Prioritization of Genomic Loci for Drug Addiction: An Example Using Alcohol Consumption 3 T6
Sarah Palumbo Electronic Health Records in Evaluating the Potential for Opioid Use Disorder B 19
Ying-Xian Pan Pharmacological functions of alternatively spliced mu opioid receptor variants in conditional Oprm1 rat models generated by Easi-CRISPR B 17
Ying-Xian Pan Alternatively spliced mu opioid receptor intracellular C-termini encoded by exon 7 are important for fentanyl actions B 18
Clarissa Parker Measuring negative affective withdrawal in CFW mice: Implications for GWAS B 16
Gary Peltz Computational Genetic Discovery for SUD 2 T2
Palsamy Periyasamy Cocaine-mediated microglial activation involves miR-148b-lncRNA XIST-DNMT1 axis-mediated epigenetic promoter DNA methylation of an anti-inflammatory gene, PPARG B 15
Roseann Peterson Cross-ancestry Genome-wide Analyses of Substance Use Behaviors in Schizophrenia: Findings from the Genomic Psychiatry Cohort. B 14
Renato Polimanti Genome-wide association study of opioid dependence from the Psychiatric Genomics Consortium B 13
Dar’ya Pozhidayeva Effects of Chronic Stimulation of Nucleus Accumbens on Binge Drinking and Transcriptome B 12
Rebecca Prosser Paternal cocaine consumption in mice sex-specifically alters F1 offspring cocaine preference, circadian rhythm responses, and striatal gene expression. B 11
Benjamin Reiner L1 retrotransposons in cocaine addiction 7 T18
Tamara Richards A Single Nucleotide Replacement Restores Methamphetamine Traits to Low Addiction Risk Levels C 21
Jim Rogers Large Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease Progression B 9
Qiu Ruan CLIP-seq analysis of the RNA binding protein hnRNP H in striatum following methamphetamine administration in Hnrnph1+/- mice B 8
Sarven Sabunciyan Repetitive Element Expression is Altered in the Brain Following Glucocorticoid Exposure B 7
Sandra Sanchez-Roige Alcohol consumption vs. misuse: evidence for distinct genetic architecture 6 T14
Michael Saul Genetics and sex govern the striatum transcriptional response to cocaine B 6
Sarah Schoenrock QTL mapping for initial sensitivity to cocaine using an F2 intercross of low and high responder inbred strains B 5
Michael Shtutman Inhibition of the DEAD Box RNA Helicase 3 prevents HIV-1 Tat- and cocaine-induced neurotoxicity by targeting microglai activation B 4
Chang Shu Peripheral blood DNA methylation markers are associated with HIV progression B 2
Chang Shu Epigenome-Wide Association Scan (EWAS) of opioid use among chronic injection drug users and in a post-mortem opioid overdose brain sample. B 3
Susan Smith Collaborative Cross RIS as a Mouse Model to Identify Genetic Polymorphisms that Modify Alcohol-Related Outcomes A 41
Ryan Smith Mapping Cell Types in the Human Putamen from Cocaine Abusers B 1
Mallory Stephenson Describing Polygenic Associations for Alcohol Use, ADHD Symptoms, Cigarette Use, and Educational Attainment: A Within-Family Comparisons Study. A 40
Jinni Su Interactive Effects Between Polygenic Risk and Social Support in Relation to Alcohol Dependence Symptoms Among European American and African American Adults A 39
Bethany Sump Molecular Mechanisms for Epigenetic Transcriptional Poised Memory State A 38
Boris Tabakoff Does the liver or the brain control voluntary alcohol consumption: using the HRDP A 37
Andrew Talal Understanding How HIV and Hepatitis C Virus (HCV) Infection Affects CYP2B6 Enzymatic Activity and Methadone Pharmacokinetics A 36
Lisa Tarantino Initial drug sensitivity and sensitization in the Collaborative Cross/Diversity Outbred founders A 35
George Taylor Selectively bred rats with low motivation to exercise may also be vulnerable to abuse drugs A 34
Samikkannu Thangavel Cocaine and HIV- Tat Impact Brain Energy Metabolism: Role in Mitochondrial Epigenetic Signature of DNA Methylation A 33
Jay Tischfield The NIDA Genomics Center Updated A 32
Joey Trampush GWAS of Cognitive Abilities and Risk for Substance Abuse A 31
Vanessa Troiani Quantitative Traits Associated with Opioid Use Disorder A 30
Jill Turner Altered Microglial Transcriptomic Changes and Signaling in the Nucleus Accumbens during Nicotine Withdrawal A 29
Mudit Tyagi Cocaine-stimulated signaling pathways enhance HIV gene expression by inducing the establishment of euchromatin structure via modulating the recruitment of different epigenetic enzymes at HIV LTR. A 28
Kathryn Vaillancourt Cocaine-related DNA methylation of IRX2 alters local 3D chromatin architecture in human brain cells. A 27
Eric Vallender Gene expression in the prefrontal cortex associated with impulsivity A 26
Jasmin Vassileva Machine learning reveals common and specific predictors of alcohol, cannabis, and nicotine dependence A 25
Brad Verhulst Developing Genome-Wide Structural Equation Modeling (GW-SEM) to analyze the genetic associations with substance use phenotypes A 24
Consuelo Walss-Bass Epigenetics of Cocaine Use Disorder: A Collaborative Case-Control Initiative in Blood and Brain A 23
Qun Wang Overdosed Vitamins Generated Epigenetic Changes to Intestinal Stem Cells A 22
Nathaniel Weathington Assessing the impact of opioid exposure on lung immune function and in acute ICU care after drug overdose A 21
George Weinstock Microbes, Novelty-Related Behavior, and Cocaine Addiction A 20
Jenny Wilkerson Non-coding RNAs as markers of opioid use and pathological pain A 19
Jessica Williams-Nguyen The importance of measuring substance use: A Mendelian randomization of chronic Hepatitis C and myocardial infarction A 18
Katherine Wilson Cocaine-induced remodeling of the nuclear lamina and 3D genome organization in neurons? A 17
Mathieu Wimmer The apple never falls far: paternal exposure to morphine has deleterious consequences on male progeny A 16
Fred Wolf A transcriptional control pathway for behavioral plasticity induced by ethanol A 15
Jennifer Wolstenholme Neighbor housing alleviates the behavioral and neurobiological consequences of social stress-induced drinking in a sex-dependent manner A 14
Hyejung Won Functional genomics resources for the human brain elucidates the neurobiological basis of schizophrenia.  A 13
Christina Woo New chemical tools to elucidate the genetics and epigenetics of opioid addiction A 12
Marcelo Wood Epigenetic mechanisms in the medial habenula control reinstatement A 11
Han Xie Validated Antibody Database: a curated database of antibodies cited in formal publications A 10
Gal Yadid Dialogue between epigenetic mechanisms and microbiome in the progress of drug addicts' rehabilitation A 9
Fengchun Ye Modulation of HIV-1 replication in microglial cells by the competing orphan nuclear receptors Nurr1 and Nor1 A 8
Xinyu Zhang Feature Selection of Smoking-Associated DNA methylation for Prediction on HIV Prognosis and Mortality A 4
John Zhang Extracellular Vesicle miRNA Screening On-Chip: Technology, Progress and Potential Application in Opioid Abuse Screening A 5
Bo Zhang Revealing the dynamic epigenetic changes of nucleus accumbens induced by methamphetamine overdose A 6
Baohong Zhang Nicotine exposure caused significant transgenerational impact on microRNA expression and related disorder in C. elegans A 7
Mike Zhang The influence of carrier proteins on the immunological efficacy of nanoparticle-based vaccines against nicotine addiction A 3
Wei Zhang A global transcriptional network connecting noncoding mutations to changes in tumor gene expression 3 T7
Shuping Zhong Role of epigenetic regulation by histone H3 phosphorylation in non-coding RNA, tRNA transcription of breast cancer A 2
Xiaoxi Zhuang N6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to Cocaine A 1

NIDA Genetics Consortium Meeting, June 16, 2018 - UCSD Campus

Abstracts & Agenda from January 2018 meeting
Submitter Title of Abstract Session
Hiba Abloushi Genome Wide Association Study of Substance Use Disorder in the United Arab Emirates population A
Bianca Acevedo Genetic markers underlying the natural addiction of love C
Balasubrahmanyam Addepalli Probing stress-induced effects on RNA and post-transcriptional modifications by LC-MS B
Arpana Agrawal Update from the Psychiatric Genetics Consortium 2
Marisela Agudelo Single cell imaging flow cytometry as a novel epigenetic tool to detect post-translational modifications and extracellular histone release induced by substance abuse B
Schahram Akbarian Nuclear transcriptome and 3D genome mapping in dopaminergic neurons of adult human midbrain 4
Ethan Anderson The histone methyltransferase G9a in the nucleus accumbens bidirectionally controls cocaine self-administration, stress-induced reinstatement, and anxiety-like behaviors A
Silviu-Alin Bacanu Novel pathway transcriptomics method greatly increases detection of molecular pathways associated with the drugs traits B
Jared Bagley Heritable variation in voluntary alcohol drinking in a genetically diverse inbred mouse panel C
Lauren Bailey Heritable variation in reward sensitivity and impulsive action and choice in a genetically diverse inbred mouse panel 5
Brandon Baker Dissecting the genetic underpinnings of cocaine and methamphetamine consumption in Drosophila melanogaster A
Sarah Barry Histone deacetylase 5 nuclear localization mediates epigenetic changes that limit drug reward and suppress relapse to drug-seeking A
James Baurley Using artificial intelligence for learning substance use disorder biosignatures C
Andrew Bergen Tobacco use disorder treatment biomarkers A
Jill Bettinger SWI/SNF chromatin remodeling complexes are required for normal behavioral responses to acute ethanol exposure D
Junaid Bhatti Impact of Genetic Polymorphisms on Opioid Misuse: A Scoping Review C
Jinbo Bi A Genome-wide Association Analysis with Cocaine Use Disorder Accounting for both Phenotypic Heterogeneity and Gene-Environment Interplay D
Jinbo Bi Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes D
Kenneth Blum Genetic Addiction Risk Score (GARS) Predicts Severity, Relapse & Personalized Medicine B
Camron Bryant Cyfip1 haploinsufficiency increases compulsive-like behavior and food consumption: Parent-of-origin effects and potential implications for Prader-Willi Syndrome A
Camron Bryant Fine mapping of a distal chromosome 1 region influencing opioid addiction traits in a reduced complexity cross D
Jason Bubier Detecting genetic variation in morphine LD50 in founder strains of the Collaborative Cross and Diversity Outbred mouse populations 7
Shilpa Buch HIV-1 Tat-mediated upregulation of miR-34a activates NF-κB-mediated microglial inflammation via targeting the 3′-UTR of NLRC5 A
Nicole Cameron Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure C
Dana Carroll Nicotine Metabolite Ratio and Biomarkers of Exposure among American Indian Tobacco Users A
Gregory Carter Modeling Pleiotropy and Epistasis to Understand Genetic Complexity 1
Hannah Cates Accumbal E2F3a mediates cocaine behaviors via transcriptome-wide regulation of gene expression and alternative splicing 7
Ramesh Chandra Cocaine-induced histone methylation on Egr3 and Nab2 promoters B
Sidi Chen Developing direct in vivo genome editing and screening platforms in the mouse brain 5
Hao Chen Social behavior and anxiety predicts nicotine self-administration in adolescent outbred rats A
Li-Shiun Chen Genetic risk, nicotine dependence, and the clinical benefit of cessation pharmacotherapy D
Christine Cheng Massively parallel single-nucleus transcriptomic profiling to identify dysregulated gene regulatory circuitry in opioid addicted human brain 8
Elissa Chesler Heterogeneous functional genomics data integration for addiction biology 5
Doo-Sup Choi Adolescence Chronic Caffeine Exposure Promotes Diurnal, Biphasic Mood Cycling and Reduces Dendritic Pruning Through DNA Epigenetics in Mice A
Pawel Ciborowski Systems Biology Approach to Investigate Epigenetic Regulation of Macrophages Exposed to HIV Infection and Methamphetamine C
Shaunna Clark Human alcohol brain methylation and biomarker discovery project A
David Cordova The Preliminary Efficacy of a Technology-Based HIV and Drug Abuse Preventive Intervention in a Youth-Centered Community Health Clinic: Opportunities for Incorporating Biomarkers of Exposure and Genetic Susceptibility A
Olivia Corradin Identifying pathogenic gene targets of noncoding GWAS risk loci using gene regulatory circuits D
Richard Crist Replication of the pharmacogenetic effect of rs678849 on buprenorphine efficacy in African-Americans with opioid use disorder B
Matthew Dalva Extracellular Phosphorylation of a Receptor Tyrosine Kinase Controls Synaptic Localization of NMDA Receptors and Regulates Pathological Pain D
Imad Damaj Cyfip2 plays an important role in nicotine reward in mice A
Mariella De Biasi The CHRNA5 variant rs16969968 alters how dopaminergic function changes during progression toward nicotine addiction and during nicotine withdrawa A
Giordano de Guglielmo Identification of genetic variants that contribute to compulsive cocaine and oxycodone intake in rats: Preliminary data and establishment of the cocaine/oxycodone biobanks 6
Rajeev Desai Role of N-Methyl-D-Aspartate Receptor (NMDAR) in Co-Morbid Schizophrenia and Substance Abuse D
Danielle Dick The Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College Students D
Ditte Demontis Genome-wide association study implicates CHRNA2 in cannabis use disorder 5
Elizabeth Do Prenatal Smoke Exposure during Pregnancy and ADHD Symptoms within Offspring: An Examination of Sex Differences and Mediation by DNA Methylation Markers A
Stella Dracheva Regulatory signatures in primate neurons at cell type resolution 4
Aimee Dudley High resolution genetic dissection of complex and quantitative traits in yeast 1
John Dziak The Effect of Varenicline on Ethanol Consumption and Striatal Gene Expression Using Classical Analytical Tools and High-Dimensional Mediation Analysis B
Howard Edenberg Transancestral meta-analysis of alcohol dependence identifies novel genetic correlations A
Marissa Ehringer Profiling differential expression of miRNA in prefrontal cortices of tobacco smokers vs. non-smokers A
Michael Engeln Transcriptional adaptations in the ventral pallidum following cocaine self-administration D
Prabagaran Esakky Paternal exposure to cigarette smoke toxicants causes adverse developmental, neurological, and behavioral outcomes in the offspring C
Babak Esmail-Azad Opioid Addiction Susceptibility Testing Via Cytochrome P450 Pharmacogenetic And Personalized Brain Region Specific (VTA) Organoid Assays B
Earl Ettienne Pharmacogenetics and Opioid Use Disorder C
Christie Fowler Nicotine-Mediated Modulation of Choroid Plexus Function and Altered Circulating MicroRNA Expression D
Reza Ghanbari Metabolomics Investigation of Opiate Addiction: Golestan Cohort Study C
Tom Gould Effects of Nicotine Exposure During Adolescence on Adult Cognition, Dendritic Morphology, and Epigenome C
Leonardo  Guercio The Blackfynn Platform for Rapid, Multi-Modal Data Integration, Analysis, and Collaboration to Enable New Approaches to Drug Addiction Research C
Peter Hamilton Engineering CRISPR constructs as tools for gene-targeted transcriptional reprogramming in mammalian brain to elucidate the causal pathogenic mechanisms of drug abuse A
Joe Harford A Nanocomplex Carrying siRNA Targeting TNFa with Potential to Blunt the Neuroinflammation that Underlies Opioid Tolerance B
Elaine Hebda-Bauer Genetics of Novelty Seeking and Propensity for Drug Abuse in Outbred Rats 6
Chad Highfill Candidate Genes for Cocaine and Methamphetamine Preference in Drosophila melanogaster A
Andrew Jaffe Effects of smoking during pregnancy on the prenatal cortical transcriptome B
Eric Johnson NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – Wave 1 2
Emma  Johnson Large genomewide association study of cannabis dependence: updates from the Substance Use Disorders working group of the Psychiatric Genomics Consortium D
Angela Junglen The role of CAMK2A in the comorbidity of PTSD/SUD in individuals seeking detoxification treatment D
Caline Karam Genome-wide association analysis of amphetamine sensitivity in Drosophila melanogaster A
Marcus Kaul Chronic, low dosage methamphetamine modifies memory performance compromised by exposure to HIV-1 Tat protein A
Vivek Kumar CYFIP2 mediated control of cocaine induced neuroadaptations in mice A
Daniel Larach Identifying genetic predictors of perioperative opioid use through a prospective cohort of genotyped and phenotyped surgical patients: The Michigan Genomics Initiative B
Todd Lencz Large-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets D
Dawei Li Deletions in the SLC25A18 and ZNF490 Genes Associated with Alcohol Dependence–A Genome-wide Copy Number Variation Screen 8
Xuan Li Role of dorsal striatal histone deacetylase 5 in incubation of methamphetamine craving C
Yutao Liu Serum Exosomes and miRNAs in Male and Female Current, Former and Non-Smokers C
Ryan Logan Circadian Rhythms and Opiates: Role of the Circadian Transcription Factor NPAS2 to Regulate Morphine Conditioned Reward C
Elizabeth Long The moderating roles of peer group deviance and parental monitoring on polygenic risk for alcohol use across adolescence B
Qing Lu A New Artificial Intelligence Tool for Substance Use and Dependence Research 5
Trudy MacKay Where is the Missing Heritability Hiding? Lessons From Drosophila 1
Pamela Madden Genetics and Epigenetics: the Addiction Phenotype, and the Adolescent Brain and Cognitive Development Study B
Supriya Mahajan Systems Biology Approach to Analysis of the Oral Microbiome in HIV-positive Opiate abusers B
Cecilia Marcondes Reactive Oxygen Species induced in innate immune cells by Methamphetamine impact RNA polymerase binding patterns and facilitate the AP-1-mediated transcription of IL1beta and TNFalpha B
Christina Markunas Genetically driven gene expression associated with nicotine dependence across ten brain regions reveals novel genes and brain regions 3
Luke Matthews Correcting for Genetic and Cultural Nonindependence (Galton’s Problem) when Testing Genetic Associations with Substance Abuse C
Ian Maze Aberrant histone dopaminylation in the ventral tegmental area promotes relapse to cocaine 9
Jacquelyn  Meyers Early Trauma Exposure, Polygenic risk for AUD, and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Oscillations during a Go/NoGo Task C
Jacquelyn  Meyers Interaction Between Polygenic Risk for Cannabis Use and Environmental Exposures In The Detroit Neighborhood Health Study C
Michael Miles Genetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) and Progenitor Mouse Strains C
Mahesh Mohan Delta-9-Tetrahydrocannabinol mediated attenuation of gastrointestinal dysfunction in chronic SIV-infected rhesus macaques involves differential modulation of epithelial DNA methylation and T cell activation D
Janitza Montalvo-Ortiz Epigenome-wide association study of opioid dependence in European American women C
Mike Neale Measurement Non-invariance with Respect to Race and Gender in DSM Criteria for Substance Abuse and Dependence D
Elliott Nelson Retrospective accounts of subjective effects of initial opioid use differ between those with opioid use disorder (OUD) and opioid misusers who never progressed to OUD C
Sean O'Sullivan Opioid Withdrawal Shifts Amygdalar Transcriptome and is Correlated with Gut Dysbiosis A
Chioma Okeoma HIV and substance abuse may influence the evolution of exosomes (exosome speciation): Implication for biosignature D
Abe Palmer Genome wide association study of behavioral, physiological and gene expression traits in a multigenerational mouse intercross B
Rohan Palmer Multivariate Genetics Architecture of DSM-5 Alcohol Use Disorder B
Ying-Xian Pan Aberrant alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of human heroin abusers and heroin self-administering rats D
Ying-Xian Pan The role of alternatively spliced mu opioid receptor C-terminal tails in morphine tolerance, physical dependence and reward D
Clarissa Parker Measuring negative affective withdrawal in CFW mice: A pilot study A
Qian Peng Genome-wide studies uncover a potential burden of uncommon variants and polygenic basis of multiple-substance use disorders in an American Indian population D
Francesca Peruzzi A miRNA signature for cognitive deficits and alcohol use disorder in persons living with HIV/AIDS D
Andreas Pfenning Cell type and Brain Region-specific Impact of Nicotine Use-associated Genetic Variation 4
Robert Philibert The Dose Response and Abstinence induced Reversion Curves for Cigarette and Alcohol Consumption using Clinically Implementable Droplet Digital PCR Assays D
Tamara Phillips MA intake and sensitization in mice with a non-functional trace amine-associated receptor 1 A
Renato Polimanti Genome-wide association study of opioid dependence in 3,491 cases and 4,163 exposed-controls from the Psychiatric Genomics Consortium A
Dina Popova Impact of OPRM1 A118G on synaptic transmission in both human and mouse neurons D
Elizabeth Prom-Wormley Genetic and Environmental Contributions to Electronic and Conventional Cigarette Use in Young Adults: A Bivariate Analysis C
Sathya Puthanveettil A Long Noncoding RNA Critical for Synapse Function B
Jill Rabinowitz The Contributions of Genetic and Contextual Factors to Alcohol and Marijuana Use and Disorders in African-American Young Adults C
Upal Roy Role of DJ1 gene in cocaine addiction and HIV-associated cognitive impairment D
Laura Saba Introducing the NIDA Core Center of Excellence in Omics, Systems Genetics, and the Addictome 6
Sarven Sabunciyan Transcriptome Differences In the Aging Schizophrenia Brain B
Wolfgang Sadee Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence A
Yotam Sagi Chromatin Remodeling Complex in Accumbal Neurons Regulates Reward and Pleasure  B
April Shu DNA methylation markers associated with injection drug use status and HIV infection among chronic injection drug users in the ALIVE study C
Dani Sisto A Novel Approach to Accounting for Exposure in Genetic Association Studies of Drug Use Disorders – An Update D
Christopher Skipwith Building a Predictive Quantitative Genomics Framework for Identifying Endophenotypes in Opioid-Dependent Patients C
Matthew Sloan The OPRM1 A118G Polymorphism and Alcohol-Related Phenotypes: Converging Evidence Against Associations with Alcohol Sensitivity and Consumption B
Lauren Slosky Self-Administration in Genetically Modified Mice: A Streamlined Platform for the Identification of Addiction Biomarkers, Therapies and Disease Mechanisms B
Kristy Soloski Can family cohesion buffer genetic risk for alcohol use trajectories? B
Bethany Stangl Dopamine Transporter (Dat1) Gene Variation And Intravenous Alcohol Self-Administration In Non-Dependent Drinkers: Influence Of Sex Differences B
Jerry Stitzel Parental nicotine exposure elicits multigenerational nicotine preference and ADHD-like brain, behavioral, and epigenetic anomalies in adolescent mice C
Laura Stroud Epigenetic regulation of placenta NR3C1: Mechanism underlying the impact of prenatal marijuana on infant development? D
Boris Tabakoff The Construction of a Tool that Predicts the Pathways from the Genome to Phenotype A
Yuan-XIing Tao Contribution of DNMT3a to neuropathic pain genesis by downregulating Kcna2 in primary afferent neurons D
Lisa Tarantino The Collaborative Cross as a tool for studying the genetics of addiction-related phenotypes B
Allison Tegge DNA methylation levels as a biomarker for severity of opioid use C
Samikkannu Thangavel Cocaine and HIV- Neuropathogenes: Epigenetic signature of DNA Methylation Role in Brain Energy Metabolism C
Thoprgeir Thorgeirsson Results from the Decode GWAS study on addiction 2
Vanessa Troiani Clinical and Genetic Risk Factors associated with Opioid Use Disorder in patients with Chronic Pain B
Eric Turner Chrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposure A
Jill Turner Disruption of Hippocampal NRG3-ErbB4 Signaling Ablates Nicotine Withdrawal-Induced Anxiety-like Behaviors A
Mudit Tyagi Cocaine-stimulated MSK1 promotes HIV transcription/replication both by augmenting the activity/recruitment of transcription factors and inducing euchromatin structures at HIV LTR B
John VanMeter The Role of DRD2 in Adolescent Reward Processing D
Jasmin  Vassileva Neurocognitive and personality dimensions of impulsivity as common and specific candidate endophenotypes for opiate and stimulant dependence C
Norma Velazquez A Drosophila model for developmental nicotine exposure A
Scott Vrieze Genetic associations with alcohol and nicotine use 3
Deena Walker Adolescent Social Stress Results in Sex-Specific Transcriptional Reprogramming of The Medial Amygdala, A Critical Region for Sex Differences in Reward B
Gemma Wallace Applying advanced statistical modeling to genetic predictors of personality dimensions associated with addiction D
Consuelo Walls-Bass Gene Expression Profiling in the Dorsolateral Prefrontal Cortex of Subjects with Completed Suicide and Substance Abuse B
Raymond Walters Closing the gap on "missing" heritability 1
Frances Wang Role of Genetically-Influenced 5-HT Functioning in a Bifactor Model of Psychopathology: Moderation by Fathers’ Substance Use Disorder D
Craig Werner Trim3 mediates cocaine craving via INO80-dependent transcriptional regulation B
Jennifer Wolstenholme Adolescent binge ethanol alters oligodendrocyte maturation and regulation of histone methylation in the PFC C
Ke Xu DNA methylation related to HIV-infected smoking associated with mortality in HIV-infected individuals C

Abstracts from November 2016 meeting

Submitter Title of Abstract Session Number
Abraham Palmer Genome-wide association study of delay discounting identifies GPM6B and demonstrates co-heritability with smoking Oral Presentation I 1
Arpana Agrawal Psychiatric Genetics Consortium Update Oral Presentation I 2
Thorgeir Thorgeirsson Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction Oral Presentation I 3
Andrew Bergen Smokescreen Translational Analysis Platform: Prediction of Nicotine Metabolism and Smoking Cessation Oral Presentation I 4
Deborah Mash Human Transcriptome Analysis of Cocaine Abuse Identifies Genes Associated with Adult Striatal Neurogenesis Oral Presentation II 1
Amanda Mitchell Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex Oral Presentation II 2
Changning Wang EPIS - Epigenetic PET imaging in substance use disorder patients Oral Presentation II 3
Heidi O'Neill Modeling gene x environmental effects in the mouse: the multigenerational phenotypes of the interaction of the rs16969968 SNP with developmental nicotine exposure. Oral Presentation II 4
Venetia Zachariou A unique role of RGSz1 in behavioral responses to pain killers Poster Session I 1
Yi Zhang Neuron subtype-specific molecular profiling and gene editing in a mouse model of cocaine addiction Poster Session I 2
John Rice Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes that contribute to the risk of nicotine dependence in European and African Americans Poster Session I 3
Alan R. Prossin Genetic moderation of human sTNFR1 response to experimental pain: potential homeostatic mechanisms underlying endogenous analgesia. Poster Session I 4
Makoto Taniguchi HDAC5 and NPAS4 regulate cocaine reward-environment associations Poster Session I 5
Patrick J. Muholland Integrative synaptomics in heavy drinking macaques identifies cross-species proteogenetic targets for treating excessive drug-seeking Poster Session I 6
Scott J. Moeller Genetic Markers Associated with Brain Structural Abnormalities in Human Cocaine Addiction Poster Session I 7
Caline Karam Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model Poster Session I 8
David Jentsch Intravenous Cocaine Self-Administration in Inbred Mice: Genetic Correlation with Impulsivity and Genome-Wide Association Results Poster Session I 9
Abraham Palmer Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Poster Session I 10
Kirk Wilhelmsen Genome-wide meta-analysis identifies seven novel susceptibility signals for nicotine dependence Poster Session I 11
Laura Saba An Influential Novel Transcript in a Systems Genetic Model of Alcohol Consumption Poster Session I 12
Betsy Ferguson A Genome-Wide Approach to Efficiently Identify Replicable DNA Methylation Regions Associated with Alcohol Use Poster Session I 13
Miri Gitik Choline supplementation in an adolescent nicotine exposure model- a whole genome epigenetic perspective. Poster Session I 14
Arpana Agrawal Genomewide association study identifies a novel locus for cannabis dependence Poster Session I 15
S. ZHONG Alcohol-induced histone H3 phosphorylation mediats RNA Pol III gene transcription Poster Session I 16
Alfredo Ghezzi CBP mediated control of long-term drug neuroadaptation in Drosophila Poster Session I 17
Mahesh Mohan Delta-9-Tetrahydrocannabinol mediated attenuation of intestinal inflammation in chronic SIV-infected rhesus macaques involves differential modulation of anti-microbial defensins, pro-inflammatory gene and microRNA expression amidst high viral loads Poster Session I 18
Danielle Dick The Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College Students Poster Session I 19
Diana Fishbein Interactions between DAT1 and OPRM1, subcortical volume and later alcohol use in alcohol naïve youth. Poster Session I 20
Kristine Marceau Cortisol-related Genes and Substance Use Severity at age 16 years Poster Session I 21
Mary Kay Lobo Cell subtype transcriptional regulation of mitochondrial dynamics in cocaine action Poster Session I 22
Yuva Kondaveeti Cocaine Induces changes in the expression of lncRNAs in T cells Poster Session I 23
Marcus Kaul HIV-1/gp120 protein and methamphetamine induce lasting alterations in four major neurotransmission systems of the central nervous system Poster Session I 24
Chioma M. Okeoma Cocaine alters semen exosome cargo composition and anti-HIV activity Poster Session I 25
Andew J. Rennekamp Target-agnostic CNS drug discovery using high-throughput behavioral chemical screening in zebrafish larvae identifies a new role for sigma-1 receptors in the vertebrate brain. Poster Session I 26
Qing Lu A New Method Founds Evidence of Genetic Heterogeneity in Nicotine Dependence Poster Session I 27
Jennifer T. Wolstenholme Adolescent binge ethanol alters histone methylation in the PFC leading to lasting memory deficits and increased ethanol sensitivity Poster Session I 28
Chris Bizon Association and Linkage Analysis of Nicotine Dependence from Whole Genome Sequencing of Family Data Suggest a Novel Role for BBS5 Poster Session I 29
Darius Bost Association of addiction phenotypes to predicted transcript levels Poster Session I 30
Gustavo Turecki Impact of chronic cocaine use on the human striatum methylome Poster Session I 31
Elisa M. Trucco A Developmental Perspective on the Role of Genes on Substance Use Disorder Poster Session II 1
Frederick Wolf SIR2/SIRT1 Disinhibition of Gene Expression by Acute Alcohol Leads to Presynaptic Changes and Behavioral Plasticity Poster Session II 2
Joseph Bloom Nicotine Dependence Associated with Functional Variation in FMO3 Poster Session II 3
Peter Hamilton Engineering zinc-finger protein and CRISPR/Cas9 constructs to model the epigenetic and transcriptional phenomena that underlie cocaine-related behaviors Poster Session II 4
Clarissa Parker Genome-wide mapping of ethanol sensitivity in the Diversity Outbred mouse population Poster Session II 5
Boris Tabakoff The Hybird Rat Diversity Rat Panel for Addiction Research Poster Session II 6
Lindsay Farrer Genome-wide Association Study of Amphetamine Related Stimulant Dependence Poster Session II 7
Brian Smith The genetic and epigenetic architecture of behaviors related to drug seeking and abuse: The honey bee as a new animal model Poster Session II 8
Scott Mackey Genetic risk and nicotine exposure interact on the structure and function of the ventromedial prefrontal cortex in adolescents Poster Session II 9
Travis T. Mallard Genome-wide polygenic scores for schizophrenia are associated with substance use during emerging adulthood Poster Session II 10
Lisa Goldberg Identification of a major QTL influencing oxycodone behavioral sensitivity and dependence in C57BL/6 substrains Poster Session II 11
David Brazel Interim results from the GSCAN exome chip project Poster Session II 12
Robert Philibert Quantitative DNA Methylation Analyses Using Digital Droplet PCR Sensitively Detects Surreptitious Smoking in Adolescents. Poster Session II 13
Phillip K. Liu Epigenetics of Drug Sensitization: MicroRNA and HDAC5 expression in Amphetamine-induced Neural Remodeling Poster Session II 14
Gal Yadid Time Window for DNA methylation in Incubation of Cocaine Craving Poster Session II 15
Fereshteh S. Nugent Epigenetic reversal of maternal deprivation-induced dopamine cell hyperexcitability and synaptic mislocalization of AKAP150 within the VTA Poster Session II 16
Pam Madden Genetics, the Addiction Phenotype, and the Adolescent Brain and Cognitive Development Study Poster Session II 17
Ana Ventuneac Integrated (iCare) at Mt. Sinai Poster Session II 18
Michael Stallings Etiological Overlap Between Impaired Sex and Risky Sexual Behavior Poster Session II 19
Kyung-An Han Genetic and social factors critical for inhibitory control Poster Session II 20
Rudra Pratyaydipta Effect of microRNA expression on alcoholism: A study in a panel of recombinant inbred mouse strains Poster Session II 21
Erin Calipari Withdrawal from cocaine self-administration alters the transcriptional profile of cocaine across six brain regions Poster Session II 22
Bradley E. Aouizerat The Women’s Interagency HIV Study (WIHS): A Diverse Cohort Well Suited to Molecular Epidemiology Studies of Substance Abuse Poster Session II 23
Ron Hart Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele Poster Session II 24
Jiang Gui Efficient Survival Multifactor Dimensionality Reduction Method for Detecting Gene-Gene Interaction Poster Session II 25
Anna Dorothy Asimes Pre-conception Maternal and Paternal Binge Alcohol Exposure Lead to Distinct DNA Methylation Patterns in Alcohol-Naive Male Offspring Poster Session II 26
Jinbo Bi Multi-view Singular Value Decomposition for Disease Subtyping and Genetic Associations Poster Session II 27
Ming D. Li A second update on susceptibility genes for nicotine dependence identified by genome-wide linkage, candidate gene association, genome-wide association, and targeted sequencing approaches Poster Session II 28
Nora Bizzozero Neuronal enriched RNA-Binding Protein HuD and microRNA miR-495 oppositely regulate cocaine induced addiction-related gene expression and place preference behavior Poster Session II 29
Ke Xu Identifying the gene co-expression module for tobacco smoking that is regulated by DNA methylation Poster Session II 30
Todd Hulgan Meth and Genetically-Predicted Expression of the Cytoskeletal Protein Spectrin Gene Neurocognitive Function in HIV Poster Session II 31
Caroline Brown Pharmacogenetic Modulation of the Behavioral Effects of Buprenorphine in a Mouse Model of the OPRM1 (A118G) Polymorphism Poster Session III 1
Zhiping Pang Synaptic mechanisms of OPRM1 A118G (MOR N40D) gene variants in human neurons Poster Session III 2
Ethan Carver Gene Regulation and Viability of Cell Cultures Exposed to E-Cigarette Refill Solutions Poster Session III 3
Z Carl Lin EIF3F Genetics of Substance Abuse Poster Session III 4
Dana Hancock Genome-wide Interaction Analysis with Sex Reveals PEX11G as a Novel Gene for Nicotine Dependence Poster Session III 5
Paulo A. Ferreira Control of gene-environment interactions by the Ran-binding protein 2 (Ranbp2) and its stresssensing partners as venues to dissect the genetic basis of addiction behaviors engendered by drug abuse Poster Session III 6
Andon N. Placzek eIF2α-mediated translational control regulates cocaine-and nicotine-induced synaptic potentiation in mouse midbrain dopamine neurons and neuronal responses in human smokers Poster Session III 7
Tamara Phillips Evidence for an epistatic effect of Oprm1 and Taar1 in risk for methamphetamine consumption Poster Session III 8
Roseann Peterson Evidence for shared genetic risk between schizophrenia and smoking behaviors: Findings from the Psychiatric Genomics Consortium. Poster Session III 9
Renato Polimanti Risk alleles identified in a genome-wide gene-by-cannabis dependence interaction analysis of risky sexual behaviors Poster Session III 10
Camron Bryant Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating Poster Session III 11
Shauna Clark Discovering methylation biomarkers of smoking and associated health risks Poster Session III 12
Ashiwel Undieh Psychostimulant-induced Alterations in Epigenetic DNA Methylation of Neural Genes: Toward a Pharmacological Separation of Euphoric and Neuroadaptive Mechanisms? Poster Session III 13
Pradeep Bhide Nicotine-induced DNA methylation in spermatozoa: Consequences for offspring’s behavior and gene expression in the brain Poster Session III 14
Jinying Zhao An Epigenome Wide Association Study on Alcohol Consumption: A Monozygotic Twin Study Poster Session III 15
S.A. Eisenstein Dopamine-related Genetic Profile is Associated with Negative Symptom Severity, Reward Expectancy, and Behavioral Inhibition Poster Session III 16
Su Guo Explore a natural variation of light/dark preference behavior in zebrafish: Genetic or epigenetic? Poster Session III 17
Michael Miles Behavioral genomic and genetic analysis of chronic nicotine and withdrawal in mouse BXD strains. Poster Session III 18
Johana Alvarez Heightened Baseline Anxiety-Like Behavior in Mice with Escalating Cocaine Consumption During Extended Access Cocaine Self-Administration Poster Session III 19
Stephen L. Boehm Short-term selective breeding for adolescent sensitivity to tetrahydrocannabinol- (THC-) induced locomotor sedation in mice. Poster Session III 20
Susan Smith High-Throughput Transcriptome Sequencing to Identify Genetic Modifiers of Sensitivity to Alcohol Poster Session III 21
Christie Fowler Nicotinic Modulation of the Choroid Plexus and Altered Circulating MicroRNA Expression During Chronic Nicotine Self-Administration Poster Session III 22
Shilpa Buch Cocaine-mediated promoter DNA methylation of microRNA-124 promotes microglial activation through TLR4 signaling Poster Session III 23
Gary Siuzdak Cloud-Based Systems Biology Analyses Guided by Metabolomics Poster Session III 24
Jinbo Bi Machine learning to identify highly heritable components of substance use disorders Poster Session III 25
Erika Andrade Neuronal Subtype-Specific Translational Changes Following Extended-Access Cocaine Self-Administration in Mice Poster Session III 26
Sudheesh Pilakka-Kanthikeel Cocaine reactivates latent HIV-1 by down regulating anti-HIV long-non coding RNAs Poster Session III 27
Ming D. Li Characterization of regulatory mechanisms at DNA variant, methylation and RNA levels for 57 tobacco smoking susceptibility genes in human brain Poster Session III 28
Brion Maher Circulating DNA methylation markers associated with injection status and HIV infection among chronic injection drug users in the ALIVE study. Poster Session III 29
Michele T. Juarez Acute exposure of Nicotine during Drosophila puncture injury activates an epidermal wound response Poster Session III 30
Richard C. Crist A polymorphism in the OPRM1 3’ untranslated region is associated with methadone efficacy in treating opioid dependence Poster Session IV 1
Imad Damaj The b3 subunit of the nicotinic acetylcholine receptor (nAChR) is required for nicotine withdrawal but not nicotine reward Poster Session IV 2
Igor Zhulin Establishing the Precise Evolutionary History of a Gene Improves Prediction of Disease-causing Missense Mutations Poster Session IV 3
Li-Shiun Chen Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes - A Meta-analysis Poster Session IV 4
Xiangning Chen Integration of Gene Expression in animal studies with GWAS in human datasets to Identify Risk Genes for Nicotine Dependence Poster Session IV 5
Jared Bagley The effects of prenatal stress on cocaine reward, cocaine locomotion and sensorimotor processing are heritable in the BXD recombinant inbred strain panel Poster Session IV 6
Rohan Palmer Estimation of the Genome-wide Additive Genetic Covariance Across Subjects of European and African Ancestry: An Example Using Alcohol Dependence Poster Session IV 7
Elliot Nelson Meta-analysis of comparisons to non-dependent misusers implicates CD244 involvement in opioid dependence Poster Session IV 8
Kirk Wilhelmsen Whole Genome Sequence Study of Cannabis Dependence: Associations with Regulatory Elements Identified by the Roadmap Epigenomics Project Poster Session IV 9
Eric O. Johnson Multi-ancestry GWAS Identifies Novel Variants Associated with HIV-1 Viral Load Set-point Poster Session IV 10
Laura Stround Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Stress Response by Maternal Smoking During Pregnancy? Poster Session IV 11
Shilpa Buch HIV-1 TAT-mediated epigenetic downregulation of miR-124 targets MECP2 and promotes microglial activation Poster Session IV 12
Michelle M. Jacobs HIV-related neurocognitive impairment is related to polymorphisms in CCR2 and CD163 in the absence of cocaine and opiate dependency Poster Session IV 13
Gregory Sartor BET bromodomains regulate neurobehavioral responses to psychostimulants Poster Session IV 14
Viranu Sueblingvong Alcohol induces profibrotic fibroblast phenotype via induction of DNA methyl transferase. Poster Session IV 15
Jasmin Vassileva Behavioral Phenotypes of Impulsivity in Substance Dependent Individuals in Protracted Abstinence: Insights from ‘Pure’ Heroin and Amphetamine Users Poster Session IV 16
Andrew Talal Telemedicine-based Management of Hepatitis C Virus (HCV) Infection for Individuals on Opiate Agonist Treatment Poster Session IV 17
Brion Maher A Novel Approach to Accounting for Exposure in Association Studies of Drug Use Disorders Poster Session IV 18
Rae Silver Novel noninvasive voluntary methamphetamine inhalation paradigm for long-term studies of neuroinflammation and drug-seeking behavior Poster Session IV 19
Kristin G. Ardlie Specificity of alternative splicing in brain tissues from the GTEx project Poster Session IV 20
Narasimhan J. Venkatachari Transcriptome analysis of Peripheral Blood Mononuclear Cells from individuals with HIV-1 associated neurocognitive disorder identifies key players associated with neuropathogenesis and Marijuana use. Poster Session IV 21
Pawel Cirborowski Systems biology approach reveals novel insights into altered functions of HIV-1-infected or methamphetamine exposed macrophages. Poster Session IV 22
Lee Campbell Creation and characterization of the HIV-nanoLuc CHME-5 cell line Poster Session IV 23
Bi Xuan A Statistical Method for Advancing Neuroimaging Genetics Poster Session IV 24
Tom Gould Paternal nicotine exposure trans-generationally alters fear response and cholinergic function: potential epigenetic mechanisms Poster Session IV 25
Dan Iancu Genetic Selection for Methamphetamine Intake Rewires Brain Transcriptional Networks Poster Session IV 26
Fereshteh S. Nugent Changes in neuronal excitability and histone modifications within the LHb may underlie anxiety and depression following early life stresses Poster Session IV 27
Shuanglin Hao Epigenetic modification of MCU in the spinal cord dorsal horn in chronic morphine tolerance and HIV-related neuropathic pain state Poster Session IV 28
Lucia Carvelli Embryonic exposure to amphetamine alters the activity of the dopamine transporter in adult animals and progeny Poster Session IV 29