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Your search for Cocaine returned 31 results. Search again.

Basic Science

Cocaine-Induced Increase in an Immune Protein Promotes Addiction Behaviors in Mice

Cocaine produces a portion of its rewarding effects by increasing levels of granulocyte-colony stimulating factor (G-CSF) in the brain’s reward center. Treatments that prevent G-CSF signaling in the nucleus accumbens might reduce motivation to use cocaine.

Basic Science

How Cocaine Cues Get Planted in the Brain

An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.

Basic Science

EEG Indicates That Cocaine Relapse Vulnerability Peaks 1 to 6 Months Into Abstinence

Electroencephalography (EEG) may provide an objective measure of cocaine-addicted participants’ vulnerability to cue-induced relapse. The assessment of cue-induced responsiveness may be useful in the clinical setting for assessing relapse risk and tailoring interventions to maintain abstinence among cocaine-addicted adults. 

Basic Science

Why Females Are More Sensitive to Cocaine

New research demonstrates that the hormone estradiol is responsible for females’ increased sensitivity to stimulant drugs.

Narrative of Discovery

Narrative of Discovery: Can Magnets Treat Cocaine Addiction? Part 3

In the final installment of this series, Dr. Diana Martinez navigates the process for receiving NIH funding to test the efficacy of using transcranial magnetic stimulation as treatment for cocaine addiction.

Basic Science

Endocannabinoid Regulates Cocaine Reward

  • Investigators have shown that 2-AG, an endocannabinoid (i.e., a cannabinoid manufactured within the body, as opposed to plant-derived), augments the cocaine-induced dopamine surge in the brain’s reward system.
  • The discovery adds to evidence that inhibiting activity in the endocannabinoid system might reduce cocaine’s rewarding and addictive effects.  
Basic Science

Impacts of Drugs on Neurotransmission

Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between brain cells. This article discusses the central importance of studying drugs’ effects on neurotransmission and describes some of the most common experimental methods used in this research. 

Treatment

Nonmedical Treatment for Cocaine Addiction Shows Promise in Pilot Trial

Patients who received transcranial magnetic stimulation (TMS) were more likely to abstain from cocaine than patients who received medications for symptoms associated with abstinence. Researchers concluded that TMS appears to be safe and its efficacy as a treatment for cocaine addiction deserves to be evaluated in a larger clinical trial.

Basic Science

¿Por qué las personas pierden el control sobre su consumo de cocaína?

Los investigadores observaron la actividad de dos tipos de neuronas en ratones: las neuronas de "impulso", que promueven los sentimientos de recompensa y la repetición de los comportamientos dirigidos a repetir las experiencias gratificantes, y las neuronas de "control", que disminuyen estos sentimientos e inhiben esos comportamientos.

Basic Science

Why Do People Lose Control Over Their Cocaine Use?

Researchers monitored the activity of two types of neurons in mice: “urge” neurons, which promote feelings of reward and repeating behaviors that have produced rewards, and “control” neurons, which dampen those feelings and inhibit behavior.

Treatment

Slow-Release Amphetamine Medication Benefits Patients With Comorbid Cocaine Addiction and ADHD

Treatment with an extended-release stimulant medication plus cognitive behavioral therapy was associated with reductions in cocaine use and in attention-deficit/hyperactivity disorder symptoms in patients with both disorders.

Narrative of Discovery

Narrative of Discovery: Can Magnets Treat Cocaine Addiction? Part 2

During investigations into using transcranial brain stimulation (TMS) to treat cocaine abuse, two projects take diverging paths. One researcher moves to the next stage, while another is forced to cut his trial short. 

Treatment

Testing a Prospective Medication To Help People Avoid Relapse

This NIDA Notes animation depicts a basic experiment that researchers use to test whether a prospective new medication can prevent relapse to drug addiction.

Basic Science

Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

Basic Science

Gene Transfer Therapy for Cocaine Addiction Passes Tests in Animals

Giving mice a modified version of a naturally occurring gene blocks cocaine’s stimulant effects without affecting the animals’ physiological or metabolic health. The new evidence advances the proposed therapy a step closer to readiness for testing in people.

Treatment

Digital Addiction Therapies Affirm Promise in Replication and Large Trial

Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.

Narrative of Discovery

Narrative of Discovery: Can Magnets Treat Cocaine Addiction?

Two researchers share their reasons for researching transcranial magnetic stimulation (TMS) for treating cocaine addiction, and describe challenges to moving forward this potentially promising therapy.

Basic Science

Why Take a Drug That No Longer Gives Pleasure?

In mice, a cocaine-induced imbalance in the activity of two key populations of neurons in the reward system persists for a longer period after repeated exposure to the drug. For long-term users, this change could both weaken the cocaine “high” and strengthen the compulsion to seek the drug.

Basic Science

Brain Imaging Predicts Relapse to Cocaine

A NIDA-supported study has found that a cocaine-addicted person’s chance of managing 1 whole year of abstinence correlates with activity levels in these impaired motivational and decision-making brain areas.

Treatment

Study Ranks Recovery Assets in Cocaine Addiction

A can-do attitude, ability to cope with potential triggers for drug use, readiness to change, and participation in self-help programs are major assets for people trying to recover from cocaine addiction.

Treatment

Dr. Thomas Kosten Q & A: Vaccines To Treat Addiction

In this article and accompanying podcast, Dr. Thomas Kosten discusses the idea and current status of antidrug vaccines to treat substance use and addiction.

Basic Science

Stress Hormone Sets the Stage for Relapse to Cocaine Use

A stressed rat will seek a dose of cocaine that is too weak to motivate an unstressed rat. Researchers traced the physiological pathway that links stress and the stress hormone corticosterone to increased dopamine activity and heightened responsiveness to cocaine.

Bulletin Board

Waletzky Memorial Award Winners’ Lectures at NIDA Illuminate Cocaine’s Many Effects on Brain Structure, Circuitry

Dr. Paul E. M. Phillips spoke on “Phasic Dopamine Transmission During Substance Abuse,” describing investigations that he has led into the role of brief, seconds-long bursts of dopamine signaling in addictive processes. Dr. Rita Z. Goldstein spoke on “Targeting the Brain, Cognition, and Motivation for Intervention in Addiction.”

Basic Science

Animation: The Rise and Fall of the Cocaine High

This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

Basic Science

Dr. Antonello Bonci Q & A: Lighting Up the Brain To Shut Down Cocaine Seeking

The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.

Basic Science

Gene Variants Reduce Opioid Risks

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

Basic Science

New Insight Into How Cues Cause Relapse to Cocaine

A brain response occurs in the nucleus accumbens when rats encounter a cue that they associate with previous cocaine self-administration, but not a cue associated with a pleasurable non-drug experience. Moreover, the response correlates in time and intensity with the animals’ cue-induced relapse to cocaine-seeking.

Basic Science

Marijuana Use May Promote Nicotine Consumption

Exposing rats to THC increases the likelihood that the animals will later self-administer nicotine. THC-exposed rats are also willing to work harder to obtain nicotine. When extrapolated to people, the findings suggest that THC’s pharmacological impact on the brain may make a person who uses marijuana more vulnerable to developing nicotine addiction, an underappreciated health consequence of marijuana use.

Public Health

In Nationwide Survey, More Students Use Marijuana, Fewer Use Other Drugs

Almost one-third (32 percent) of the roughly 42,000 Monitoring the Future survey respondents reported having used marijuana during their lifetime. However, abuse of many other drugs—methamphetamine, heroin, cocaine, and some prescription medications—declined.

Prevention

Intervention Strengthens American Indian Teen Mothers’ Parenting

Teen mothers on three American Indian reservations improved on several measures of parenting after participating in Family Spirit, a home-visiting intervention developed with NIDA support. At 12 months postpartum, the women’s children exhibited reduced rates of emotional difficulties predicting later drug abuse and other behavioral problems. Infants at highest risk—those whose mothers had histories of drug abuse—benefited the most.

Basic Science

Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

NIDA Notes

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