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Treatment

Serotonin Receptor Agonist Lorcaserin Reduces Relapse to Drug Use in Monkeys

The serotonin 2C receptor agonist lorcaserin reduced reinstatement of drug-seeking behavior in response to heroin or cocaine in a nonhuman primate model of relapse.

Basic Science

Part 2: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

Researchers move their monoclonal antibody (mAb) into clinical trials to see if it can be an effective treatment for methamphetamine use.

Basic Science

Part 1: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

Researchers have created a monoclonal antibody (mAb) that is intended to interact with methamphetamine and decrease its ability to enter the brain.

Narrative of Discovery

Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 4

Dr. Linda Dwoskin wins a NIDA grant to continue her team's work to find a medication to treat methamphetamine addiction—but there's a string attached.

Treatment

A Promising Alternative to Opioid Pain Medications

An experimental compound with a dual action at two opioid receptors may provide powerful pain relief without many of opioids' harmful side effects.

Treatment

In Animals, Opioid Combination Shows Promise for Safer Pain Relief

In rats, the combination treatment of oxycodone/nalfurafine had lower levels of abuse liability and produced less respiratory depression than oxycodone alone.

Treatment

Novel Compound Alleviates Hard-to-Treat Pain in Mice

A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.

Narrative of Discovery

Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3

Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first ever medication to treat methamphetamine addiction.

Basic Science

Promising Advances in the Search for Safer Opioids

New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

Treatment

Quinine as a Tracer for Medication Adherence

Patients who don’t take their medications as prescribed often put themselves at risk for problems including misdiagnoses, complications, and death. A study suggests that adding low doses of quinine to patients’ medications could provide an inexpensive, reliable, and safe method of monitoring whether patients are taking their medications as directed.

Treatment

Dual Regimen Aims To Shorten Medication-Assisted Therapy

Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.

Narrative of Discovery

Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction, Part 2

When lobeline turned out not to be the answer, it became a starting point. Dr. Linda Dwoskin and her team set out to transform the molecule into something more effective and with fewer side effects.

Treatment

Testing a Prospective Medication To Help People Avoid Relapse

This NIDA Notes animation depicts a basic experiment that researchers use to test whether a prospective new medication can prevent relapse to drug addiction.

NIDA Notes

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