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NIDA Notes

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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction, Part 2 (April 2016)

When lobeline turned out not to be the answer, it became a starting point. Dr. Linda Dwoskin and her team set out to transform the molecule into something more effective and with fewer side effects.

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Testing a Prospective Medication To Help People Avoid Relapse (March 2016)

This NIDA Notes animation depicts a basic experiment that researchers use to test whether a prospective new medication can prevent relapse to drug addiction.

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Gene Variant Is Associated With Reduced HIV Transmission (March 2016)

A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.

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Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals (February 2016)

The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals’ attraction to environments in which they have experienced cocaine’s effects.

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ED-Initiated Buprenorphine Outperforms Referral or SBIRT for ED Patients With Opioid Addiction (January 2016)

Emergency department visits present prime opportunities to identify people with opioid addiction and provide them with onsite initiation of treatment with buprenorphine/naloxone.

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Gene Transfer Therapy for Cocaine Addiction Passes Tests in Animals (January 2016)

Giving mice a modified version of a naturally occurring gene blocks cocaine’s stimulant effects without affecting the animals’ physiological or metabolic health. The new evidence advances the proposed therapy a step closer to readiness for testing in people.

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Life Skills Training Shields Teens From Prescription Opioid Misuse (December 2015)

Communities that implemented Life Skills Training in a trial more than recouped its cost in reduced health, social, and other expenditures related to teen prescription opioid misuse.

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Long-Term Follow-Up of Medication-Assisted Treatment for Addiction to Pain Relievers Yields “Cause for Optimism” (November 2015)

In the first long-term follow-up of patients treated with buprenorphine/naloxone for addiction to opioid pain relievers, half reported that they were abstinent from the drugs 18 months after starting the therapy.

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Digital Addiction Therapies Affirm Promise in Replication and Large Trial (November 2015)

Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.

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Childhood Maltreatment Changes Cortical Network Architecture and May Raise Risk for Substance Use (November 2015)

Young adults who had been maltreated as children differed from others who had not been maltreated in the connectivity of nine cortical regions. The differences could compromise the maltreated group’s basic social perceptual skills, ability to maintain a healthy balance between introversion and extroversion, and ability to self-regulate their emotions and behavior.

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