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Extended-release naltrexone lowers relapse rates in ex-offenders

Science Spotlight

March 31, 2016

little Hand in jail©istockphoto/kwanchaichaiudom

New research funded by the National Institute on Drug Abuse (NIDA) revealed that the initial relapse rates among opioid-dependent adults in the criminal justice system was lower for participants receiving extended-release naltrexone than for those receiving treatment as usual (brief counseling and referrals for community treatment programs). Administered as a monthly injection, naltrexone is an FDA-approved sustained-release, opioid antagonist for the prevention of relapse to opioid dependence.

This study is the first large randomized trial of extended-release naltrexone versus usual care conditions among criminal justice involved adults. The findings showed that 24 weeks (six monthly injections) of extended-release naltrexone resulted in a significantly lower opioid relapse rate (43 percent vs. 64 percent) among the two groups. Additionally, while there were no overdoses observed in the extended-release naltrexone group, there were seven in the usual care group, with three resulting in fatalities.  

For a copy of the abstract, “Extended-Release Naltrexone to Prevent Opioid Relapse in Ex-Offenders,” published in The New England Journal of Medicine, go to http://www.nejm.org/doi/10.1056/NEJMoa1505409.

For more information about criminal justice and drug abuse, including Principles of Drug Abuse Treatment for Criminal Justice Populations - A Research-Based Guide, go to: https://www.drugabuse.gov/related-topics/criminal-justice-drug-abuse

For more information, contact the NIDA press office at media@nida.nih.gov or 301-443-6245. Follow NIDA on Twitter and Facebook

Contact:
NIDA Press Office
301-443-6245
media@nida.nih.gov

About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at www.drugabuse.gov, which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@nida.nih.gov. Online ordering is available at drugpubs.drugabuse.gov. NIDA’s media guide can be found at www.drugabuse.gov/publications/media-guide/dear-journalist, and its easy-to-read website can be found at www.easyread.drugabuse.gov. You can follow NIDA on Twitter and Facebook.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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    NIDA (1430). Extended-release naltrexone lowers relapse rates in ex-offenders. Retrieved , from https://www.drugabuse.gov/news-events/news-releases/2016/03/extended-release-naltrexone-lowers-relapse-rates-in-ex-offenders

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