A revealing look at the brain on heroin
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A NIDA-funded study reveals major changes in the brains of heroin users.
Latest from NIDA
New clinician screening tool available for substance use
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The National Institute on Drug Abuse (NIDA) Clinical Trials Network has unveiled a new scientifically validated, online screening tool designed to assess a patient’s risk for substance misuse and substance...
Training module now available for acute pain management in hospitalized adults
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A case-based clinician training module designed for the evaluation of acute pain and opioid management for adults is now available through the Centers of Excellence in Pain Education (CoEPE) program...
Scientists discover path to better pain medicines
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In this this NIDA-funded research, scientists used a novel approach to compare the cell signaling initiated by kappa opioids that produce dysphoria from those that do not.
Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT
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This clinical trial: Found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they...
Analysis of insurance coverage for back pain shows missed opportunities to prescribe non-opioid medications
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A comprehensive analysis of health insurance coverage of non-opioid and opioid medications to treat chronic low back pain concluded that some insurance plans have missed important opportunities to steer patients...
Methadone and buprenorphine reduce risk of death after opioid overdose
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A National Institutes of Health-funded study found that treatment of opioid use disorder with either methadone or buprenorphine following a nonfatal opioid overdose is associated with significant reductions in opioid...
In Animals, Opioid Combination Shows Promise for Safer Pain Relief
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This study found that: In rats, co-administration with nalfurafine reduced the dose of oxycodone required to lower pain responses in models of human chronic pain. The combination treatment generated less...
A Gene Links Impulsivity and Drug Use Vulnerability
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This research: Identified a gene variant that promotes impulsive behavior and enhanced responses to heroin in rats. Linked the corresponding human gene variant to increased risk for impulsivity and drug...
Novel Compound Alleviates Hard-to-Treat Pain in Mice
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A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.
Special journal issue highlights ABCD brain study
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The special issue is an overview of the ABCD Study and includes articles about the rationale for the study, its design and recruitment strategy, assessment protocols and neuroimaging parameters, the...
Too Hot And Too Cold: Dysregulation of key brain networks in people with addiction
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Study suggests that brain activity is not simply too high or low in people who are addicted to drugs, but behaves differently to drug and non-drug stimuli.
Full survey of annual teen drug use now available with additional data
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The complete volume of the 2017 Monitoring the Future Survey (MTF) teen drug use and behavior survey results is now available online with never before seen highlights about drug use...
Cigarette Smoking Increases the Likelihood of Drug Use Relapse
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This research: Found that cigarette smoking increased the likelihood of relapse among people in recovery from substance use disorder (SUD). Suggests that helping patients quit and remain abstinent from smoking...
Higher rate of substance use among Native American youth on reservations
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A survey comparing drug use among Native American youth living on or near reservations to a national sample of American youth found that Native American youth report substantially higher use...
Breathing under the influence of … fentanyl
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An animal study at NIDA's intramural research labs suggests fentanyl-induced respiratory depression affects the temperature of the brain, triggering brain hypoxia and hyperglycemia.
Method to identify undetected drug suicides wins top NIDA Addiction Science Award
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A project that identified and tested a bioinformatics program that can help identify underreported suicides linked to drug overdoses was awarded the first-place distinction at the 2018 Intel International Science...
FDA approves first medication to reduce opioid withdrawal symptoms
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Lofexidine, the first medication for use in reducing symptoms associated with opioid withdrawal in adults, has been approved by the U.S. Food and Drug Administration.
What science says about Tobacco + Marijuana + Pregnancy
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A NIDA-funded study suggests that pregnant women who smoke both marijuana and cigarettes have a higher likelihood of smaller babies and increased maternal stress and aggression.
Study upends conventional view of opioid mechanism of action
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A new discovery shows that opioids used to treat pain, such as morphine and oxycodone, produce their effects by binding to receptors inside neurons, contrary to conventional wisdom that they...
Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3
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Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first-ever medication to treat methamphetamine addiction. She and colleagues at the Universities of...
Nearly half of opioid-related overdose deaths involve fentanyl
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An analysis of opioid-related overdose deaths found that synthetic opioids, such as illicit fentanyl, have surpassed prescription opioids as the most common drug involved in overdose deaths in the U.S.
Dr. Kurt Rasmussen to lead NIDA’s therapeutics and medical consequences division
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The National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health, welcomed Dr. Kurt Rasmussen today as the Director of the Division of Therapeutics and Medical...
Understanding the Neuroscience of Addiction: what it means for prevention and treatment
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Advances in the understanding of brain development, as well as the role that genes and environment play in addiction, are the focus of a review article published today in The...
Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients
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In this research: Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics. Neither pain severity nor...
Overdose drug shows promise as stroke treatment
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Preclinical research lays the groundwork for developing the first drug to promote recovery from ischemic stroke, a leading cause of adult disability.
Five million American adults misusing prescription stimulants
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Looking at annual averages, approximately 6.6% (or 16 million) of U.S. adults used prescription stimulants in the preceding year; 4.5% (or 11 million) used prescription stimulants appropriately (without misuse); 2.1%...
Communities That Care program shows success in reducing substance use and behavioral issues in adolescents
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The CTC is a prevention planning and implementation system that trains community coalition is to assess their community’s needs, then select and use evidence-based programs and policies to reduce risk...
Study changes long-held concepts of cell decoding
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Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body's hard-working G protein-coupled...
Study highlights how opioid receptors organize to block pain
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A NIDA-funded study explored how opioids such as morphine act within pain circuits in the brain and spinal cord, while attaching to receptors on the surface of nerve cells (neurons).