Combination treatment for methamphetamine use disorder shows promise in NIH study
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Combination medication may be effective in treating adults with methamphetamine use disorder
Latest from NIDA
People With SUDs Have Increased Risk for COVID-19 and Worse Outcomes
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People with a substance use disorder (SUD) at any time in their lives are 1.5 times more likely to contract COVID-19 than those without an SUD, and those with a...
Physician-pharmacist collaboration may increase adherence to opioid addiction treatment
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NIH-supported pilot study found team-based approach may improve buprenorphine care
Substance Use Status Important When Developing HIV Therapies
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Animal studies suggest that subjects with HIV who suffer from opioid use disorders may have higher viral reservoirs in the central nervous system than non-opioid users.
Decision-Making in Ambiguous Situations Influences OUD Patients’ Relapse Risk
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Patients in treatment for opioid use disorder (OUD) who were more comfortable making decisions when they did not know the probability of outcome had a higher risk of using opioids...
Study: Surge of teen vaping levels off, but remains high as of early 2020
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Annual Monitoring the Future (MTF) survey results released.
Unraveling neuroHIV in the Presence of Substance Use Disorders
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These reviews address how each of these addictive substances and HIV individually or collectively affect the immune system and subsequent clinical and behavioral outcomes
How the Brain Makes Pain Unpleasant
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A specific collection of neurons in the basolateral amygdala, a brain region crucial for affect, was active when mice experienced pain. Deactivating this collection of neurons resulted in a loss...
Elite Controllers May Hold Key to an HIV Cure
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"Science" Magazine Breakthrough of the Year Runner Up for 2020
Amy Hauck Newman appointed to lead NIDA’s Intramural Research Program
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Dr. Newman officially began her new position at the NIDA IRP on November 22, 2020.
HIV and Methamphetamine Use: Double Jeopardy for Transmission of the Novel Coronavirus.
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The authors suggest that co-occurring methamphetamine use and HIV present a double jeopardy for COVID.
Neighborhood conditions associated with children’s cognitive function
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NIH-funded research from ABCD Study finds association despite household income.
NIH study tests a comprehensive model intervention to reduce opioid overdose deaths in hard-hit communities
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COVID-19 brings challenges, learning opportunities
NIH-funded study links adolescent brain differences to increased waist circumference
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Finding from ABCD Study elucidates neural mechanisms that may underlie early weight gain
Narrative of Discovery: The Quest for a Medication to Treat Methamphetamine Addiction, Part 5
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In the summer of 2019, Dr. Linda Dwoskin and her research team felt they were in a promising place in their decades-long search for a treatment for the 700,000 Americans...
Vaping, marijuana use in 2019 rose in college-age adults
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Increases are among the largest in history of national study
Gaps in Substance Use Treatment Services for HIV Patients Around the Globe
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
Substance use disorders linked to COVID-19 susceptibility
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NIH research finds higher risk and worse outcomes for those with addiction
Cocaine Triggers Endocannabinoid Release Through a Novel Mechanism
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Cocaine can trigger release of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the ventral tegmental area of the midbrain in mice, and this may play a role in cocaine use disorder.
Prenatal Cannabis Exposure Alters Brain Reward Circuitry in Male Rats
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Prenatal cannabis exposure (PCE) increased sensitivity to THC in male rats, but not female rats, during pre-adolescence. PCE increased dopamine release in response to THC and altered the properties of...
Two Different Brain Regions Are Linked With Nicotine Addiction Severity and Nicotine Withdrawal
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Activity in the striatum of people who smoke changed less in response to positive feedback/reward than in nonsmokers; this effect was more pronounced with greater addiction severity. Activity of the...
Treating Substance Use Disorders Can Reduce HIV Burden in U.S. Cities
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Concerted efforts and substantial investments in HIV prevention and care in the United States have resulted in considerable reduction in new diagnoses and death since the mid-1990s. To identify best...
Parents’ Marijuana Use May Increase Children’s Risk of Marijuana Use and Favorable Views of Marijuana
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This study found that children’s risk of marijuana and alcohol use and attitudes toward marijuana were influenced by their parents’ marijuana use pattern over time.
Clues to Regulating HIV-1 Viral Gene Expression
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
Researchers Identify Rare Gene Variants Associated With Smoking and Alcohol Use
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International research teams analyzed several hundred thousand samples from 17 whole-exome sequencing studies to identify rare gene variants associated with smoking and alcohol use. They identified rare variants in 117...
Shape shifters: The dynamic role of GCPRs in drug discovery
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the...
Expression of a Gene in the Brain Links Nicotine Addiction to Diabetes
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Rats with a disrupted transcription factor 7-like 2 (Tcf7l2) gene in the medial habenula showed markedly greater nicotine intake than control rats. Reduced Tcf7l2 expression in the medial habenula reduced...
NIDA launches drug education booklet series for middle school students
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The National Institute on Drug Abuse (NIDA) has launched a redesigned series of booklets geared towards educating middle school students about substance use. The Mind Matters series consists of nine...
Learning how to disrupt cocaine’s effects on the brain
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular...
Landmark study of adolescent brain development renews for additional seven years
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With nearly $290M of new funding for seven years to research institutions around the country, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development (ABCD)...