Overdose drug shows promise as stroke treatment
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Preclinical research lays the groundwork for developing the first drug to promote recovery from ischemic stroke, a leading cause of adult disability.
Research Highlights
Communities That Care program shows success in reducing substance use and behavioral issues in adolescents
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The CTC is a prevention planning and implementation system that trains community coalition is to assess their community’s needs, then select and use evidence-based programs and policies to reduce risk...
Listening to Patients’ Voices in Developing New Opioid Addiction Treatments
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One of the pillars of the current federal initiatives to end the opioid crisis is the development of new medications to treat opioid addiction. The FDA Patient-Focused Drug Development Initiative...
Study highlights how opioid receptors organize to block pain
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A NIDA-funded study explored how opioids such as morphine act within pain circuits in the brain and spinal cord, while attaching to receptors on the surface of nerve cells (neurons).
What Does It Mean When We Call Addiction a Brain Disorder?
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Informed Americans no longer view addiction as a moral failing, and more and more policymakers are recognizing that punishment is an ineffective and inappropriate tool for addressing a person’s drug...
Gut-brain axis offers clues to treatments for addictive disorders
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Scientists have investigated how the stomach-derived hormone ghrelin affects alcohol-seeking behaviors, discovering for the first time in humans that administration of ghrelin intravenously significantly increased alcohol intake in heavy drinking...
Stimulating news about brain glutamate
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NIDA-funded scientists conducted the first study showing that the signaling transmitter glutamate increases in the brain after stimulant use in humans, which has a greater effect in females.
Why Marijuana Displeases
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Through research on mice, a mechanism for how THC, the active ingredient in marijuana can produce rewarding, neutral or negative experiences was demonstrated.
Teens, E-Cigs and Toxins?
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NIDA-funded scientists have found at least five potentially harmful toxins in the body of human adolescents who use electronic cigarettes.
Repurposed arthritis drug could become a non-opioid pain reliever
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A compound once studied as an arthritis therapy has been given new life as a possible non-opioid pain reliever by NIDA-funded scientists.
The brain's hyper-network uncovered
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Complex brain actions reflect multiple networks of activity in the brain, according to a paper authored by researchers from the NIDA Intramural Research Program, in collaboration with scientists from Italy...
Neuronal ensembles take center stage
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A new animal study from NIDA's Intramural Research Program (IRP) shines light on the underlying mechanisms in the brain's prefrontal cortex and its role in learning.
Could Naltrexone Be Used to Treat Pregnant Women with Opioid Addiction?
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A recent study published in Lancet found that extended-release naltrexone was equally effective at reducing illicit opioid use as the partial agonist buprenorphine if patients could be successfully initiated on...
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This study found that: Marijuana users exhibited six different patterns of marijuana use from ages 18 to 50. Longer-term marijuana use (extending from age 18 into the late 20s or...
Brain Structure Tracks Reward's Value and Steps to Obtain It
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Scientists at the National Institute on Drug Abuse’s Intramural Research Program (NIDA IRP) have demonstrated distinct roles for two subregions of the orbitofrontal cortex (OFC) in goal-directed behaviors.
Stressful Experiences Affect Likelihood of Remission of Drug Dependence, Continued Drug Use, and Relapse
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This study: Showed that stressful life events are associated with reductions in a person’s chances of becoming or remaining abstinent from drugs for at least 3 years. Suggests that coping...
Study shows e-cigarettes affect brain similarly to other nicotine sources
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Nicotine-containing electronic cigarettes (e-cigs) produce brain changes similar to those caused by other nicotine sources, such as combustible cigarettes or nicotine lozenges, a study sponsored by the National Institute on...
Marijuana drug use increasing during pregnancy
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Marijuana is the most commonly used illicit drug during pregnancy, and its use is rising.
Hospital best practices linked to modest changes in prescription opioid dispensing
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The authors of this study assessed whether the Washington state hospital mandates had any impact on Medicaid beneficiary opioid dispensing rates after an ED visit.
A Family-Oriented Intervention May Reduce the Effects of Poverty on Brain Development
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This study found that: Childhood poverty was associated with reduced volumes of limbic brain regions in adulthood. The reduced limbic volumes were associated with depression and smoking in adulthood. Participation...
A “New Vista” for Treating Cocaine Addiction
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Two recent studies suggest that medications that activate a pair of opioid receptors may weaken cocaine users’ drive to take the stimulant.
Available Soon: NIDA’s Research E-Cigarette
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NIDA and NJOY, LLC, have developed a Standard Research E-Cigarette. The device will help researchers resolve many outstanding questions about how e-cigarettes affect health.
NIDA’s Past-Year Achievements Point the Way Toward Future Advances
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2017 brought exciting new basic science findings, including some striking new insights into the structure and functioning of receptors that play important roles in substance use, addiction, and pain.
Oxytocin protocol appears workable and safe for methadone patients who use cocaine
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Researchers supported by the National Institute on Drug Abuse have developed a protocol for adjunctive oxytocin treatment, and a pilot study has indicated that it is workable and safe for...