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Mice genetically engineered to lack mu opioid receptors in the medial habenula were less sensitive to the unpleasant effects of the opioid antagonist naloxone and showed fewer naloxone-induced withdrawal symptoms.
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As people across the U.S. and the rest of the world contend with coronavirus disease 2019 (COVID-19), the research community should be alert to the possibility that it could hit...
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About 1 in 20 patients treated for a nonfatal opioid overdose in an emergency department died within 1 year of their visit, many within 2 days. Two-thirds of these deaths...
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This week, March 30 through April 5, 2020, is the 10th National Drug and Alcohol Facts Week (NDAFW), a yearly observance organized by NIDA in partnership with the National Institute...
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In this study, both rats and humans learned to predict differently flavored rewards in parallel choice tasks, showing that dopamine neurons are carrying much more information than previously thought.
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The degree of connectivity of a neuronal network in the rat brain before nicotine exposure can help predict nicotine dependence severity after nicotine exposure as well as reversal of dependence...
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This rodent study offers the first mechanistic explanation for the protective effect of social interaction related to incubation of craving, showing for the first time the role of a specific...
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Today, NIDA issued a Request for Information (RFI) from the research community and any other interested parties regarding the establishment of a standard unit dose of THC in order to...
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The serotonin 2C receptor agonist lorcaserin reduced reinstatement of drug-seeking behavior in response to heroin or cocaine in a nonhuman primate model of relapse.
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Most common mental disorders, from depression and anxiety to PTSD, are associated with disturbed sleep, and substance use disorders are no exception. The relationship may be complex and bidirectional: Substance...
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People's decisions to use e-cigarettes, as well as perceptions about associated risks, are influenced by the e-cigarettes' nicotine levels and available flavors. The influence of these characteristics on decision-making and...
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In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related...
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Computational modeling by NIDA scientists suggests the possible use of adenosine A2A receptor antagonists to counteract the adverse effects of cannabinoids.
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This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir—targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9...
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An analysis of Medicaid records shows that less than one-third of youths treated for a nonfatal opioid overdose received timely follow-up treatment, and only 1 in 54 youths received recommended...
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Neuroscience research from NIDA’s Intramural Research Program suggests that cortical mechanisms, especially in the orbitofrontal cortex, are likely involved in attentional bias to cocaine associated environmental cues and offer a...
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As NIDA sets its sights on new goals and objectives for 2020 and beyond, I like to reflect on how far we have come in our research efforts, especially as...
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Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.
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As we enter a new year, we would like to honor and thank NIDA Notes Editor David Anderson, who recently retired after 20 years at the helm of NIDA’s signature...
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The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects
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Newly published research from NIDA funded scientists offers new insight into how opioid receptors work to regulate chemical communication in the brain. The researchers discover unexpected receptor mobility and diffusion...
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This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the...
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For the second year in a row, rapid rises in vaping among adolescents are the top story from the Monitoring the Future survey of drug use and attitudes among the...
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In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA...
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NIDA scientists examine an accepted model of the causes of depression to determine its usefulness as a foundation to predict the probability of prescription opioid use disorder.