A man's hand with a red HIV ribbon

Drug use increases risk for getting or passing on viral infections because certain viruses can spread through blood or body fluids shared in drug use and related activity. This happens with men and women, primarily in two ways: (1) when people inject drugs and share needles or other drug equipment, and (2) when drugs impair judgment and people have unprotected sex with a person living with HIV. NIDA’s AIDS Research Program supports an innovative and multidisciplinary HIV/AIDS research portfolio.

Sharing drug injection equipment and drug-related sexual behavior are both part of the complex relationship between HIV transmission and substance use.

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Clinical Trials

Clinical trials are research studies in human volunteers conducted to answer specific health questions. Learn about the NIH-sponsored clinical trials available to you.

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