NIDA Genetic Consortium Meetings & Abstracts

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the September 11-12, 2025 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Registration and Meeting support information

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September 11, 2025 - Session 1
NameEmailAbstract Title
Nora Volkow, M.D., Director, NIDA Welcome
Brock Grillbrock.grill@seattlechildrens.org Session 1: Using Large-Scale Genetics to Decipher Signaling Networks that Regulate Opioid Behavioral Responses
September 11 - Session 2: CoGenome-scale Exploration of the Opioid-Exposed Human Brain - From Tissues to Cells to Single Chromatin Fibers (9:40–10:45 a.m.)
Co-Chairs: Olivia Corradin, Ph.D., Massachusetts Institute of Technology
Eric Johnson, Ph.D., RTI International
NameEmailAbstract Title
Olivia Corradincorradin@wi.mit.edu Epigenetic variation linked to opioid overdose converge on splicing regulators in the nucleus accumbens
Aman Agarwalaman.agarwal@mssm.edu Genome-scale long-read single molecule sequencing for nucleosome position mapping and transcription factor footprinting in opioid exposed and control prefrontal cortex
Caryn Williscdwillis@rti.org Differential gene expression of opioid overdose death across human brain regions
September 11 – Session 3: Concurrent Panels (1:30–3:00 p.m.):
Harnessing Model Organism Genetics and Genomics in the Understanding the Role of Human Genetic Variation in SUDs
Co-Chairs:
Elissa Chesler, Ph.D., The Jackson Laboratory
Abraham Palmer, Ph.D., University of California San Diego
NameEmailAbstract Title
Elissa Cheslerelissa.chesler@jax.org Using Mouse Behavioral Phenomics to Interpret and Model Genetic Variation in Substance Use Disorders
Abraham Palmeraap@ucsd.edu Genetic evidence supports a relationship between locomotor activity in a novel environment in rodents a human externalizing behavior
Marianne Seneyseneyml@upmc.edu Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in  Human and Rodent Brains
Xia Yangxyang123@g.ucla.edu Mergeomics, A Multiomics Integration and Network Modeling Tool and Its Applications in Addiction Research
Impact of Substance Abuse on HIV Gene Expression and Neuroinflammation Dynamics
Co-Chairs:
Mudit Tyagi, Ph.D., Thomas Jefferson University
Palsamy Periyasamy, Ph.D., University of Nebraska Medical Center
NameEmailAbstract Title
Shilpa Buchsbuch@unmc.edu  Extracellular vesicles and microRNA crosstalk: Modulators of neuroinflammation in HIV-1 and opioid-associated neurocognitive disorders
Palsamy Periyasamypalsamy.periyasamy@unmc.edu Epigenetic Regulation of NLRP6 Inflammasome in Methamphetamine-Induced Neuroinflammation and Astrocyte Pyroptosis
Mudit Tyagimudit.tyagi@jefferson.edu Cocaine enhances HIV infection, gene expression, and replication by stimulating  cell metabolism through the regulation of multiple pathways
September 11 – Session 4: Short Talks (3:00–4:00 p.m.)
NameEmailAbstract Title
Risa Watanaberisa.watanabe@mssm.edu Chromatin Fiber Profiling and Transcription Factor Footprinting by Genome-Scale Single Molecule Sequencing from Opioid Use Disorder and Control Brain
Nana Amissahnanaamis@buffalo.edu Genomic Loci Influencing Addiction-Like Behaviors During Cocaine Self-Administration
Julie Blendyblendy@pennmedicine.upenn.edu Spatial Transcriptomics Reveals Distinct Cell Type Dynamics Following the Development of Opioid Dependence
Zhong Chenzchen@llu.edu  Paired-Tag Single-Cell Joint Profiling of H3k27me3-H3k4me1 and Transcriptome Revealed Prenatal E-Cigarette Induced Abnormal Neuronal Lineage Development in Rat Neonatal Prefrontal Cortex
Andrew Ricearice@bcm.edu Single-cell Analysis of Prefrontal Cortex Reveals Cell Specific Accelerated Aging in People with HIV-1
Deziree Colemandezcole@uw.edu Cross-Species C. Elegans Model of Opioid-Induced Behavior Identifies Gao and a Multi-Layered RGS Profile Mediating Opioid Receptor Signaling
Xiaoke Duanxiaoke.duan@yale.edu Single Nucleus Transcriptome and Chromatin Analysis Identifies Basal Ganglia Differentially Expressed Genes for SIV Infection in Rhesus Macaques: Preliminary Findings
Elaine Hebda-Bauerhebda@umich.edu Triangulating Genotyping, RNAseq, and Spatial Transcriptomics in a Rat Model of Temperament and Addiction
Daniel Jacobsonjacobsonda@ornl.gov   Human-First Drug Repurposing for Addiction: From AI-Informed Multi-Omics Systems Biology Through Candidate Drug Validation and Trial Emulation
September 12 – Session 5: Molecular and Cellular Logic Underlying Drug-Seeking and Relapse Across Cell Type- and Circuit-Specific Populations (9:05–10:30 a.m.)
Co-Chairs:
Ian Maze, Icahn School of Medicine at Mount Sinai
Keri Martinowich, Johns Hopkins University
NameEmailAbstract Title
Newaz AhmedNewaz.ahmed@mssm.edu   Ex-specific chromatin and transcriptional signatures in medial prefrontal cortex following heroin exposures
Soren Emersonsoren.d.emerson@vanderbilt.edu Molecular Determinants of Ensemble Recruitment
Isaiah Williamsoniwilliamson@som.umaryland.edu Adaptations in the parabrachial nucleus after chronic opioid exposure and withdrawal
Beau Osterbeauo@jhmi.edu Transcriptional impact of chronic fentanyl self-administration on habenula circuits
September 12 – Session 6: Concurrent Panels (1:15–2:30 p.m.): Regulation of Alternative Splicing in Addiction
Co-Chairs:
Elizabeth A Heller, Ph.D., University of Pennsylvania
Amy Lasek, Ph.D., Virginia Commonwealth University
NameEmailAbstract Title
Luana CarvalhoLuana.MartinsdeCarvalho@vcuhealth.org  PCBP1-Mediated Alternative Splicing in the Hippocampus During Alcohol Withdrawal
Elizabeth Hellereheller@pennmedicine.upenn.edu Chromatin- and activity-mediated alternative splicing in sucrose and cocaine reward
Karla Kaunkarla_kaun@brown.edu Functional consequences of alternative splicing in polysubstance use
Rohan PalmerRohan.Palmer@Emory.edu Genomic and Transcriptomic Splicing Associations in Opioid and Alcohol Use Disorder
Clinical Utility of Implementation of Genetic Data into Personalized Medicine Approach to Substance Use Disorder (SUD)
Co-Chairs:
Tanya Ramey, M.D., Ph.D., NIDA
Albert Arias, M.D., Virginia Commonwealth University
NameEmailAbstract Title
Albert Ariasalbert.arias@vcuhealth.org  Toward Precision Treatment of Substance Use Disorders with Machine Learning Models and Pharmacogenetics
Laura Jean BierutLaura@wustl.edu Polygenic scores for substance use disorder:  Uses for prevention and treatment
Danielle DickDanielle.m.dick@rutgers.edu Integrating Genomic and Environmental Information to Deliver Personalized Feedback on Substance Use Disorder Risk: The Comprehensive Addiction Risk Evaluation System (CARES)
Marjorie Gondré-Lewismgondre-Lewis@howard.edu Neurogenetic Risk for Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine
September 12 – Session 7: Short Talks (4:00–5:00 p.m.)
NameEmailAbstract Title
Matthew Lanelanemj@ornl.gov Binding Pathways to Break Addiction: Multiomic Insights into GLP-1R Agonist Therapeutics for Cigarette Smoking and Opioid Addiction
Joseph Nadeaujnadeau3@mmc.orgNon-Genetic Non-Environmental Phenotypic Variation in Health and Disease
Emilly Orreorr@wustl.edu  Applying High Throughput Deep Mutational Scanning (DMS) to Study Transcription Factors (Tfs) Implicated in the Biology of Substance Use Disorders (SUD)
Andreas Pfenningapfenning@cmu.edu  Cell Type Specific Enhancers for the Primate Dorsolateral Prefrontal Cortex
Ana Pomboapombo1@ju.edu A Single Exposure to Cocaine Rewires the 3D Genome Structure of Midbrain Dopamine Neurons
Holly Pooreholly.poore@rutgers.edu Advancing Gene Discovery for Substance Use Disorders Using Additional Traits Related to Behavioral Disinibition
Melody Rivera-Hernándezmelody.rivera-hernandez@yale.edu Prioritizing Brain Cell Types and Biological Processes Linked to OUD-Associated Common Genetic Variants
Katherine Savellkatherine.savell@nih.gov Identifying the Transcriptional Fingerprint of a Drug Reward Memory
Jing Sunjsun54@jhmi.edu Reduced Mitochondrial DNA Copy Number in Persons who Inject Cocaine and Heroin
September 11 – Poster Session A (10:45 a.m.–12:15 p.m.)
Poster NumberNameEmailAbstract Title
1Alexia Alsumalexia.alsum@uky.edu Probing Neuronal Circuit Dynamics: Calcium Imaging Comparison of a Novel Mu Opioid Agonist and Oxycodone Effects in the Medial Prefrontal Cortex
2Luis Araujoluis.araujo@vcuhealth.org Longitudinal bidirectional effects between ADHD and educational performance in the ABCD study
3Svitlana Bachsvitlana.bach@libd.org Molecular profiling of the human nucleus accumbens with spatial and single nucleus resolution
4Ryan Bachtellbachtell@Colorado.edu Dysregulated oxycodone use in select inbred rat strains from the Hybrid Rat Diversity Panel
5Roberto Baileyrobertobailey@hunterschools.org Prenatal Cannabis Exposure and Neurodevelopmental Gene Up-regulation: Longitudinal Impact on Childhood Cortisol Levels
6Jared Balbonajared.v.balbona@gmail.com Sex-Specific Genetic Effects in Substance Use Disorders: A Meta-Analysis of Sex-Stratified GWAS Across Over 2 Million Individuals
7Brad Baldersonbbalderson@salk.edu Decoding the Biological Basis of Opioid Addiction using Single Nuclei RNA-seq and Chromatin Accessibility from the Nucleus Accumbens of Outbred Rats
8Zia Barnardzbarnard@wi.mit.edu Deciphering the Molecular Effects of Acute and Chronic-Intermittent Opioid Exposure on iPSC-derived Medium Spiny Neurons
9Britahny Baskinb.baskin@northeastern.edu Cocaine intravenous self-administration in near-isogenic Spontaneously Hypertensive Rat substrains bred in-house and QTL analysis of cocaine locomotor sensitivity and gene expression (RNA, protein) in an F2 cross
10Andrew Bergenawbergen2@gmail.com Demographic and Social Determinants of Methadone Dose and Treatment Outcomes Among Patients Receiving Medication Assisted Treatment in New Jersey Based Programs
11Ramji Bhandaribhandarir@missouri.edu Paternal THC exposure effects on their fertility and offspring reproductive health
12Jennifer Blackburnjennifer.blackburn@yale.edu Physiological and immunomodulatory effects of Δ-9-tetrahydrocannabinol depend on HIV serostatus
13Claire Brabanderclaire.brabander@qc.cuny.edu Susceptibility to substance use initiation: the developmental cascade from placental HPA-axis programming to infant temperament
14Elissa CheslerElissa.Chesler@jax.org Host genotype affects microbiome composition and behavior
15Cali Calarcoccalarco@som.umaryland.edu Regulation of metabolism-related gene expression by cocaine self-administration in mouse nucleus accumbens circuits
16Samar Chehimisamar.chehimi@pennmedicine.upenn.edu Multiomic analysis uncovers gene expression and chromatin accessibility changes in the nucleus accumbens of rats after cocaine self-administration
17Hao Chenhchen@uthsc.edu Initial QTL mapping of oral oxycodone self-administration in the hybrid rat diversity panel
18Youshu Chengyoushu.cheng@yale.edu Inferred cell-type-specific methylation quantitative trait loci for cannabis use
19Raymond Chienrc1268@njms.rutgers.edu Investigating the molecular mechanisms underlying morphine tolerance using tandem mass tag-based phosphoproteomics/proteomics
20Maia Choimaia.choi@rutgers.edu Genetic, neural, psychological, and environmental factors are uniquely associated with onset of alcohol use in the Adolescent Brain Cognitive Development (ABCD) study
21Richard Cristcrist@pennmedicine.upenn.edu Morphine self-administration and withdrawal produce sex- and cell type-specific transcriptomic changes in the rat nucleus accumbens
22Konrad Dabrowskikonrad.dabrowski@mssm.edu Chromatin accessibility patterns in peripheral blood cells as predictors of opioid dependence and recovery
23Genevieve Dashgenevieve.dash@rutgers.edu Implementation of a Genetically-Informed Personalized Feedback Intervention
24Christal Davischristal.davis@va.gov Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans
25Mariella De Biasimarielde@pennmedicine.upenn.edu CHRNA5 is Necessary for the Neuroadaptations Associated with Chronic Alcohol Exposure
26Joseph DeakJoseph.Deak@yale.edu A large-scale genome-wide association meta-analysis study of cocaine use disorder
27Michelle Doylem3doyle@health.ucsd.edu From Genes to Treatments: Leveraging Rat Genetic Diversity to Unlock Novel Therapeutic Targets in Alcohol Use Disorder
28Eamonn Duffyeamonn.duffy@colorado.edu Oxycodone self-administration alters the diversity and composition of the fecal and cecal microbiome in two genetically divergent rat strains
29Taylor Eldertaylor.elder@uky.edu Modulation of the Affective Withdrawal Phenotype in Nicotine Use Disorder: The Role of Intranasal Fingolimod
30Michael Emeryemeryma@med.umich.edu Comparison of intravenous self-administration of psychostimulants vs. opioids in an animal model of internalizing vs externalizing temperament
31Fang Fangffang@rti.org Reversibility of DNA Methylation Changes Associated with Cannabis Use
32Madeline Fishmadeline.fish@umassmed.eduUsing single cell multiomics to discover novel factors in the brain involved in co-occuring opioid addiction and major depression
33N. Dalton Fitzgeraldndf@uab.edu Neuronal activation by cocaine varies across molecularly-defined subpopulations of VTA dopamine neurons
34Leigh Flynnltf28@drexel.edu Effects of Intraperitoneal Psilocybin on DNA Methylation and Electrophysiological Markers of Plasticity
35Chen FuChen.Fu@umassmed.edu Increased somatic mutation rate and transcriptome noise in OUD patients in NAc and sgAcc
36Michael Garvinmike@williwawbio.com Long-read sequencing identifies CYP2D6 haplotype associated with frequent cocaine use
37Olivier Georgeolgeorge@health.ucsd.edu The Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration
38Laura Goetzllaura.goetzl@uth.tmc.edu Prenatal cannabis exposure alters miRNA expression in the developing human brain
39Gbadebo Ogungbadedebogungbade@gmail.com RN3C1 Glucocorticoid Receptor Gene and Serotonin Gene (5-HTT) Aberrant Epigenomic Modulation in Maternal Depressive Disorders (MDD) among Racial/Ethnic Minorities in the US: Quantitative Evidence synthesis (QES)
40Stephanie JonesStephanie_K_Jones@baylor.edu Early cannabis use in adolescents associates with high-order gene by environment interactions identified by machine learning
September 11 – Poster Session B (4:00–5:30 p.m.)
Poster NumberNameEmailAbstract Title
1Marjorie Gondré-Lewismgondre-Lewis@howard.edu Neurogenetic Risk for Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine
2Struan Grantgrants@chop.edu Shared and unique 3D genomic features of substance use disorders across multiple cell types
3Feng Guofrankfengguo@gmail.com Engineering human brain organoids for understanding substance use disorders
4Gbadebo Ogungbadedebogungbade@gmail.com Pediatric Chronic Oxycodone and CYP2D6 Aberrant Epigenomic Modulations in Autistic Spectrum Disorders (ASD): Quantitative Evidence Synthesis (QES)
5Michael Garvinmike@williwawbio.com Biologically-driven epistasis as a new way of approaching genetic analyses of addiction
6Jason Hammondsjason.hammonds@cchmc.org HIV infection induces rapid activation of HAND-associated inflammatory signatures in microglia
7Emily Hartwellemily.hartwell@pennmedicine.upenn.edu Stratified multi-ancestry GWAS of alcohol use and depression: Unique genetic architecture
8Alexander Hatoumashatoum@wustl.edu GWAS of Neuroimaging Derived Subtypes of Alcohol Use Disorder
9Jinshan Hejinshan.he@osumc.edu Methamphetamine-Induced Upregulation of Deubiquitinating Enzymes (DUBs) Promote HIV Proviral Transcription by Enhancing SWI/SNF Chromatin Remodeling Complex
10Charles Hoeffercharles.hoeffer@colorado.edu Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
11Ava HolmesAva.Holmes@nih.gov MultipleXed Population Selection and Enrichment single nucleus RNA sequencing (XPoSE-seq) enables sample identity retention during transcriptional profiling of target populations
12Yike Huangy.huang@wi.mit.edu Linking Stress to Opioid Addiction: Exploring Genetic and Neuroepigenetic Mechanisms
13Jessica Huebschmanhuebschm@musc.edu NPAS4-Expressing Ensemble in the Nucleus Accumbens Facilitates Reward-Related Behavior
14I-Tzu Hungih256@rutgers.edu Detecting rGE between Exposome Factors and Polygenic Risk Scores for Psychiatric and Substance Use Disorders in the Adolescent Brain Cognitive Development Study
15Rohan Palmerrohan.palmer@emory.edu Examining the Effects of Prenatal Cannabis Exposure & Genetic Risk for Externalizing Traits on Executive Functioning and Behavioral Disinhibition in Early Adolescence
16Natalia Jaume-Feliciosinjaume@emory.edu The Co-Occurrence of Internalizing Disorders and Alcohol Use Disorder: An Examination of Childhood Trauma and Epigenetic Cellular Aging
17Alvin Jefferya.jeffery@vumc.org Precision Phenotyping of Opioid Use Disorder for Multiple Populations
18Zeal Jinwalazeal.jinwala@pennmedicine.upenn.edu Predicting Treatment-Seeking Status for Alcohol Use Disorder- A machine learning approach
19Ken Johnsonken.b.johnson@hsc.utah.edu mRNA & miRNA expression in taxane induced peripheral neuropathy during taxane treatment: A 12-month longitudinal analysis
20Stephanie JonesStephanie_K_Jones@baylor.edu  Polygenic risk scores incorporating functional genomics improve prediction of smoking cessation
21Emily Jorgensenejorgens@uab.edu CRISPR-based manipulation of KCNQ channel subunits reveals unique contributions to striatal neuron activity
22Marcus Kaulmarcus.kaul@medsch.ucr.edu Methamphetamine increases release of pro-inflammatory cysteinyl leukotrienes and neurotoxicity of HIV-infected iPSC-derived microglia
23Jack Keadyjack.keady@uky.edu Cell-type Specific Impacts of Chronic Nicotine Vapor Exposure and Spontaneous Withdrawal on the Murine Hippocampus
24Yousef Khanyousef.khan@pennmedicine.upenn.edu Multi-Ancestry Genome-Wide Association Meta-Analysis of Buprenorphine Treatment Response
25Drew Kiralydkiraly@wakehealth.edu Dissection of gut-brain signaling pathways in models of cocaine use disorder with single cell resolution
26Vidhya Kumaresanvidhya@bu.edu Abstinence from Escalated Cocaine Intake Alters the microRNA Landscape in the Medial Prefrontal Cortex
27Phil LeePLEE0@mgh.harvard.edu Environmental, Genetic, and Neural Correlates of Adolescent Polysubstance Use: Insights from the ABCD Study
28Adele Leggieria.leggieri@qmul.ac.uk Genetic and Developmental Analysis of Zebrafish Reveals Candidate Genes Linked to Nicotine Addiction Vulnerability and Impulsivity
29Paige Lemenplemen1@uthsc.edu Adolescent Social Isolation Increases Sensitivity to Pain and Opioid Use in Adulthood in Rats
30Lingyong Lilingyongli@uabmc.edu Tiam1 signaling in morphine-induced behavioral and structural plasticity
31Ming Lilimd586@outlook.com Multiomics analyses reveal significant association of SNP rs148582811 in ARVCF with smoking addiction by affecting nicotine-associated hippocampus-dependent
32Mingrui Limingrui.li@yale.edu Delta-9-Tetrahydrocannabinol Dynamically Alters Transcriptome at Single-Nucleus Resolution in Humans
33Xiaoyu Liangliangx20@msu.edu Tobacco Exposure is Associated with Unique Cell-Type Specific Epigenetic Modifications Across Immune Cell Types
34Hongyu Linhlin123@umd.edu A novel role of submedius thalamus and its projections to orbitofrontal cortex in incubation of oxycodone craving after forced abstinence
35Z. Carl Linzlin@mclean.harvard.edu Human epistatic mechanisms in polysubstance use disorders
36Duan Liuliu.duan@mayo.edu Alcohol Use Disorder Associated Gene FNDC4 Affects Glutamatergic and GABAergic Neurogenesis in Human iPSC-derived Neural Organoids
37Shirelle Liuliu00459@umn.edu Epigenetic regulation in the medial prefrontal cortex underlying vulnerability to opioid use disorder throughout its trajectory in male and female rats
38Shuai Liushuai.liu@som.umaryland.edu Cellular and molecular adaptations from cue-induced cocaine relapse within VTA- projecting ventral pallidum neurons in mice
39Andrew Lombardianlo5057@colorado.edu Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
40Cecilia McCormickcmccormick@nygenome.org A Single Cell Approach to Study Cocaine Use Disorder
September 12 – Poster Session C (10:30 a.m.–12:00 p.m.)
Poster NumberNameEmailAbstract Title
1Chang Luchanglu@vt.edu Neonatal opioid exposure alters epigenomic regulations of immune response genes in mouse brain
2Qing Lulucienq@ufl.edu Mixed Deep Learning for Analyzing Large-scale Substance Use Disorders Genetic Data
3Tianzhou Matma0929@umd.edu Integration of multiple QTL data to reveal the causal relationship between DNA methylation and nicotine addiction
4Hermine Maeshermine.maes@vcuhealth.org Analysis of Transmissible Liability Index in longitudinal twin datasets for studying resistance to substance use
5Supriya Mahajansmahajan@buffalo.edu Role of Complement Activation in HIV Neuropathogenesis Associated with Methamphetamine (METH) Abuse
6Travis MallarTMALLARD@mgh.harvard.edu Advancing genomic understanding of externalizing psychopathology via a multi-ancestry GWAS of 3 million individuals
7José-Jaime Martínez-Magañajose.martinez-magana@yale.edu Local ancestry-aware meta-analysis of genome-wide association studies for substance use traits in Latin American populations
8Chloe Mathesoncmatheso@umd.edu Mitochondrial morphology in orbitofrontal cortical neurons during incubation of oxycodone craving
9Megan Matthewsmegamatt@sas.upenn.edu The next revolution in activity-based protein profiling: uncovering the target of a 70-year-old drug leads to a breakthrough in female biology and a novel therapeutic strategy to treat (pre)eclampsia and other deadly neurological disorders
10Alex Milleralexmill@iu.edu  Genome-wide association meta-analysis of early onset cannabis use
11Sophia Miraclesmiracle@bu.edu Enhanced naloxone-precipitated withdrawal-induced aversion following oxycodone administration in Zhx2 knockout mice
12Shamsudheen Moidunnysxm1464@med.miami.edu Role of Microbiota-derived Butyrate in Depression Associated with HIV-1 and Opioid Use
13Joseph Mosquerajmosquera@health.ucsd.edu Mapping Brain FOS Reactivity in Genetically Diverse Rats Reveals Cortico-Striatal-Thalamic Network Vulnerabilities Associated with Oxycodone Addiction-like Behavior
14Anna Moszczynskaamosz@wayne.edu Methamphetamine Self-administration Alters Cell Type-specific Gene Expression in the Rat Nucleus Accumbens
15Daniel Munrodmunro@health.ucsd.edu Deep analysis of transcriptome identifies molecular mediators of substance use disorders in rats
16Cassie Nelsonc.nelson@som.umaryland.edu Monitoring Oprm1 expression in the parabrachial nucleus throughout the induction of opioid dependence and withdrawal
17Elliot Nelsonnelsone@wustl.edu The first GWAS of opioid overdose death yields surprisingly strong associations and trans-ancestral agreement
18Wickensonn Norzéwickensonn.norze@temple.edu Differential effects of self-administration of opioid receptor agonists with varying potency on exosomal blood serum and orbital frontal cortex (OFC) miRNA expression patterns
19Carlos Novoacmn5622@psu.edu Genetic background modulates anxiety-related behaviors and the impact of adolescent social stress on acute responses to nicotine in BXD mice
20Jimmy Olusakinjolusakin@som.umaryland.edu  Prenatal Stress and THC Exposure Impact Maternal and Adolescent Behaviors
21Emmanuel OnaiviONAIVIE@WPUNJ.EDU Dopaminergic and microglia Cnr2 gene knockout reveals biased neuroinflammation signaling
22Yingshi Ouyangouyangy@mwri.magee.edu  The impact of prenatal opioid exposure on placental opioid receptors
23Abraham Palmeraap@ucsd.edu Getting the run around: is the locomotor response to a novel environment behavior model a model of human externalizing behavior?
24Rameez Syedrameez.ali.syed@emory.edu CONSILIENCE-GWAS: A Web Resource for Parsed Heritability & Polygenic Score Analysis of Human GWAS Using Heterogeneous Functional Genomics Data
25Qian Pengqpeng@scripps.edu Common Threads: Uncovering Convergent Pathways for Cannabis Use Disorder Across Diverse Populations
26Sonja Plasilsplasil@health.ucsd.edu Gene-wide association study of opioid-induced allodynia during withdrawal in heterogeneous stock rats
27Emily Prantzalosepr246@uky.edu Genetic Disruption of Neuregulin Signaling in the PFC: Insights into Nicotine Exposure and Withdrawal
28Marta Pratellimpratelli@ucsd.edu Methamphetamine induces switching neurotransmitter in multiple brain regions
29Bryan Quachbquach@rti.org Multi-omic network analysis identifies gene modules linked to both frequent cocaine use and the HIV reservoir in CD4+ T cells
30Fatir Qureshiqureshi@wi.mit.edu  Uncovering Environmentally Associated Epigenetic Regulatory Mechanisms in Opioid Exposure Using Chromatin QTL Mapping and Foundation Models
31Timea Raffaitimea.raffai8@gmail.com Integrated analysis of heroin-induced microRNA and mRNA profiles in the nucleus accumbens reveals concerted regulation of miRNA-mediated pathways
32Barkha Ramnanibarkhar@umich.edu Impact of Opioids on HIV-induced innate immune response and pathogenesis
33Daniel Reeddr55@rice.edu CRISPR epigenome editing for interrogating the role of DNA methylation at Fosb locus
34Benjamin Reinerbcreiner@pennmedicine.upenn.edu Multiomic signatures of early life adversity elucidate mechanisms of adult addiction trajectories
35Pamela Romero Villelarpamela@wustl.edu  Maternal Smoking during Pregnancy Interacts with Genetic Factors to Increase Risk  for Low Birth Weight but not Harmful Offspring Smoking Behaviors in Europeans
36Mukisa Ronaldmukisaronald17@gmail.com Epigenetic Signatures of Adiposity in Ugandan Populations: An Epigenome-Wide Association Analysis RODAM Study
37Pavana Rottiprotti@wi.mit.edu Understanding the role of insulin signaling in the prefrontal cortex (PFC) of opioid overdose cases
38Siara Rouzersrouzer@tamu.edu Prenatal co-exposure to cannabinoids and alcohol disrupts transcriptomic and microbial profiles of alcohol-seeking offspring
39Laura SabaLaura.Saba@cuanschutz.edu Evidence of genetically-driven latent factors in longitudinal oxycodone self-administration data from the Hybrid Rat Diversity Panel
40Xiaoxi Zhuangxzhuang@bsd.uchicago.edu The RNA-binding protein YTHDF1 mediates translational control by m6A mRNA methylation in learning
41Gbadebo Ogungbadedebogungbade@gmail.com Tryptophan Hydroxylase (TPH) gene and 5-HTTLPR polymorphism in Childhood Suicidal Ideation and Suicide among Children
42Vivek Swarupvswarup@uci.edu Unraveling Transcriptomic Dynamics of Early-Life Adversity and its Sex-Dependent Impact on Opioid Addiction Vulnerability
September 12 – Poster Session D (2:30–4:00 p.m.)
Poster NumberNameEmailAbstract Title
1Gbadebo Ogungbadedebogungbade@gmail.com Aberrant Epigenomic Modulations of Glucocorticoids Receptor Gene (NR3C1) as Causal Inference in Major Depressive Disorders (MDD): Quantitative Evidence synthesis (QES)
2Gbadebo Ogungbadedebogungbade@gmail.com Glucocorticoid receptor (NR3C1), Serotonin (5-HTT), Glutamate Decarboxylase (GAD1/GAD2)  Genes  in Childhood  Aberrant Epigenomic Modulation in Bipolar Affective Disorder (BPAD) and  Generalized Anxiety Disorders (GAD) in the USA: QES
3Sandra Sanchez-Roigesanchezroige@ucsd.edu Genome-Wide Association Analysis of an in Silico Phenotype Sourced from Clinical notes: The Addiction Behavior Checklist
4Sandra Sanchez-Roigesanchezroige@ucsd.edu Genetic heterogeneity across dimensions of alcohol use behaviors
5Varshini Sathishv1sathis@ucsd.edu  Identifying Genetic Risk Factors for Opioid Use Disorder in Chronic Pain Patients using the AllOfUs Research Dataset
6Samantha Scottsamantha.scott@som.umaryland.edu  Mitochondrial dynamics in ventral hippocampal neurons after prolonged abstinence from cocaine self-administration
7Michael Setzermichael.setzer@usuhs.edu Phenotypic and Genetic relationship between ADHD and SUDs in the Yale-Penn cohort
8Jakob Shaykink.shaykin@uky.edu Evaluating the Role of Microglia in the PFC on Fentanyl Escalation Using PLX 3997 in Sprague-Dawley Rats
9Mike SheldonMichael.Sheldon@sampled.com The NIDA Center for Genetic Studies at SAMPLED Develops Novel Multiomic Solutions for NIDA Investigators: A Case Study
10Eleni Siaesia@clin.au.dk Neuroepigenomics of THC and CBD Exposure during Pregnancy in the Developing Brain
11Maya Solismsolis22@miners.utep.edu Gene X Exposome for Impulsivity
12Sheetal Sreeramsxs2286@case.edu METH induced disruption of homeostasis and HIV mediated neuroinflammation in microglia containing human cerebral organoids
13Kyle Sullivansullivanka@ornl.gov Identifying integrated pathways among multi-omics of nicotine addiction using network embedding approaches
14Boris Tabakoffboris.tabakoff@cuanschutz.edu Revisiting the DNA “Dark Matter”
15Makoto Taniguchitaniguch@musc.edu A long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation
16Lisa Tarantinolisat@med.unc.edu Life at the extremes: leveraging phenotypic diversity to identify mechanisms of substance use disorders
17Erica Teixeira Pratesteixeiraprae@ornl.gov Uncovering Off-Target Mechanisms of GLP-1R Agonists in Opioid Addiction via AI and Structural Systems Biology
18Francesca Teleseftelese@ucsd.edu Exploring Immature Neurons in the Adolescent Nucleus Accumbens and Their Connection to Cannabis Use
19Rose Sciortinoros4010@med.cornell.edu Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning
20Fatemeh Abdollahy BiroonFAbdollahyBiroon@som.umaryland.edu Exploring the Placental Methylome: Identifying Genetic Markers for Severe Neonatal Opioid Withdrawal Syndrome
21Makeda Turnermakeda.turner@som.umaryland.edu  Investigating Pro-inflammatory Cytokines in Opioid-exposed Pregnancies
22Guy Twagtwa@uab.edu Multiomic profiling reveals cell type-specific chromatin accessibility in the rat nucleus accumbens
23Mudit Tyagimudit.tyagi@jefferson.edu Effect of cocaine, Human Immunodeficiency Virus (HIV) Tat peptide, and antiretroviral drugs on human brain microvascular endothelial cells
24Thomas Vondriskatvondriska@mednet.ucla.edu Chromatin structural proteins as integrators of metabolic, hormonal and biomechanical stress
25Junshi Wangjunshi.wang@mssm.edu Single-cell spatial sequencing and connectomic mapping of the interpeduncular nucleus reveal sex-dependent mechanisms of opioid reward
26Lu Wanglu.wang.lw763@yale.edu Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
27Xu Wangxuwang@temple.edu TLR3 activation of human iPSC-derived brain organoids induces antiviral factors
28Ze Zhong Wangwangzezhong13@gmail.com Studying synaptic transmission under opioid exposure using hiPSC-derived midbrain model and hyperspectral fluorescence lifetime imaging
29Bradley WebbBradley.webb@vcuhealth.org Empirical assessment of substance use disorders phenotype strategies for maximizing genetic discovery power in biobanks
30Jennifer Whistlerjlwhistler@ucdavis.edu Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic voluntary morphine
31Hyejung Wonhyejung_won@med.unc.edu Genetic basis of pleiotropy
32Zheng-Xiong Xizxi@intra.nida.nih.gov Dissecting the role of midbrain GABA neurons in cannabinoid reward and aversion using conditional CB1 receptor knockout mice
33Yang Xiaoyangxa@umich.edu Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
34Lei Xielxie@iscb.org Advancing Programmable Human Digital Twins for Substance Use Disorder Drug Discovery
35Eric Xingepxing@cs.cmu.edu FM-Association Analysis: A New Paradigm For Multi-Omic Association Mapping to Complex Clinical Phenotypes
36Hang Yaohyao@ucsd.edu Fentanyl exposure disrupts cellular and molecular integrity in human midbrain organoids
37Huiping Zhanghuipingz@bu.edu Effects of Chronic Intermittent Ethanol (CIE) Exposure on Global m6A RNA Methylation and m6A Regulatory Gene Expression in Mouse Liver
38Quan Zhuquzhu@ucsd.edu Mapping the Spatial Epigenomic Landscape of Opioid Addiction and Its Neuronal Circuitry in the Paraventricular Thalamus to Nucleus Accumbens Pathway
39Xiaoxi Zhuangxzhuang@bsd.uchicago.edu Anti-homeostatic excessive alcohol consumption exacerbated by vitamin B6 deficiency in Drosophila
40Yanning Zuoy3zuo@health.ucsd.edu From Rats to Humans: Revealing Conserved Molecular Networks in Addiction through Gene Expression and GWAS Integration
41Peter Hamiltonpeter.hamilton@vcuhealth.org KZFP function within medium spiny neurons enables molecular and behavioral responses to cocaine
Presenter Unable to Attend
NameEmailAbstract Title
Meghan Chenowethmeghan.chenoweth@utoronto.ca Transcriptome-wide association studies leveraging biomarker data offer etiologic insights into tobacco smoking and schizophrenia
Gabor Egervarigabor@wustl.edu Male Acss2 KO mice exhibit decreased voluntary alcohol intake and blunted ventral striatal chromatin and gene expression changes after drinking
Marsida Kallupimkallupi@health.ucsd.edu Prewired for Addiction: Amygdala GABA Dysregulation Predicts Cocaine Vulnerability
Nadejda Korneevanadejda.korneeva@lsuhs.edu Translation regulation in development of opioid tolerance and hyperalgesia
Patricia Maidana Miguelpatricia.maidanamiguel@mail.mcgill.ca Sex-specific developmental gene networks linking risk-taking behaviors in rodents and humans
Chaitanya Srinivasancsriniv1@andrew.cmu.edu Machine learning prioritization of cell type-specific enhancers in the nucleus accumbens implicated in addiction predispostion

Past Genetic Meeting – May 2024