April 20, 2017
In 2015, over 33,000 Americans died from opioids—either prescription drugs or heroin or, in many cases, more powerful synthetic opioids like fentanyl. Hidden behind the terrible epidemic of opioid overdose deaths looms the fact that many of these deaths are far from accidental. They are suicides.
Let me share with you some chilling data from three recent studies that have investigated the issue.
In a study of nearly 5 million veterans recently published in Addiction, scientists reported that presence of a diagnosis of any substance use disorder and specifically diagnoses of opioid use disorders (OUD) led to increased risk of suicide for both males and females. The risk for suicide death was over 2-fold for men with OUD. For women, it was more than 8-fold. Interestingly, when the researchers controlled the statistical analyses for other factors, including comorbid psychiatric diagnoses, greater suicide risk for females with opioid use disorder remained quite elevated, still more than two times greater than that for unaffected women. For men, it was 30 percent greater. The researchers also calculated that the suicide rate among those with OUD was 86.9/100,000. Compare that with already alarming rate of 14/100,000 in the general US population.
You may be tempted to think that these shocking findings about the effects of OUD on suicide risk are true for this very special population. But that turns out not to be the case.
Another US study, published last month in the Journal of Psychiatric Research, focused on 41,053 participants from the 2014 National Survey of Drug Use and Health. This survey uses a sample specifically designed to be representative of the entire US population. After controlling for overall health and psychiatric conditions, the researchers found that prescription opioid misuse was associated with anywhere between a 40 and 60 percent increased risk for suicidal ideation (thoughts of suicide). Those reporting at least weekly opioid misuse were at much greater risk for suicide planning and attempts than those who used less often. They were about 75 percent more likely to make plans for a suicide and made suicide attempts at a rate 200 percent greater than those unaffected.
Using a different strategy, a review of the literature in the journal Drug and Alcohol Dependence estimated standardized mortality ratios for suicide. This is a way of comparing the risk of death in individuals with a given condition compared to individuals from the general population. The researchers found that for people with OUD, the standardized mortality ratio was 1,351 and for injection drug use it was 1,373. This means that compared to the general population, OUD and injection drug use are both associated with a more than 13-fold increased risk for suicide death.
These are stunning numbers and should be a strong call to action.
Persons who suffer from OUD are highly stigmatized. They often talk about their experience that others view them as “not deserving” treatment or “not deserving” to be rescued if they overdose because they are perceived as a scourge on society. The devastating impact of this brain disorder needs to be addressed. People who could be productive members of society and contribute to their families, their communities, and the general economy deserve treatment and attention.
As a country, we desperately need to overcome stigmatizing attitudes and confront the problem. We need to understand what causes some individuals to become addicted when exposed to opioids and thus study the biological basis of the disease of opioid addiction. We desperately need to know what the best treatments are for a given individual, and for that too, we need research to identify biomarkers for treatment response. And given the fact that effective medications exist but are drastically underutilized, we need to overcome institutional and attitudinal barriers to these treatments and deliver them to the 24 million people who could benefit. It can prevent not only the suffering of addiction and the danger of unintentional overdose but also help prevent the tragic outcome of opioid-related suicide.
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About This Blog
Welcome to my blog, here I highlight important work being done at NIDA and other news related to the science of drug abuse and addiction.
Dr. Nora Volkow: Video Highlights
- National Committee for Quality Assurance (NCQA): Quality Talks, October 2016
Treating Addiction Within the Health Care System
- APA TV, May 2016
APA TV chats with Dr. Nora Volkow, the Director of NIDA to hear about her lecture on drug abuse and the opioid epidemic.
- Kentucky Educational Television, May 2016
One to One with Bill Goodman: Dr. Nora Volkow
- TEDMED, January 2015
Why do our brains get addicted?
- The World Science Festival, May 2013
Meet Pioneer in Science, Dr. Nora Volkow
- Rockburn Presents, November 2012
Dr. Nora Volkow
- Brookhaven National Laboratory WBNL Video, October 2012
Chemistry celebration: FDG: Contribution to Our Understanding of Addiction
- CBS 60 Minutes, April 2012
Hooked: Why Bad Habits Are Hard to Break
- Science Times, June 2011
Dr. Nora Volkow