A compound once studied as an arthritis therapy has been given new life as a possible non-opioid pain reliever by NIDA-funded scientists. When used in combination with morphine, the cannabinoid agonist drug appears to block chemotherapy-induced neuropathic pain while decreasing signs of opioid dependence in mice.
- Hohmann, et al. Slowly Signaling G Protein–Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Molecular Pharmacology. http://molpharm.aspetjournals.org/content/suppl/2017/11/30/mol.117.109355.DC1