En español
NIDA

NIDA researchers discover further complexity in brain reward circuitry

Science Spotlight

February 09, 2015

Illustration of neuron signal transmission

NIDA scientists have identified new complexities within the brain’s reward circuitry that involves two major chemicals involved in drug addiction -- dopamine and glutamate. Researchers used rodent models to better understand a specific brain circuit where dopamine and glutamate are both released from the same brain cells. They found that dopamine and glutamate were typically stored separately from one another and released from different synapses of the nerve cell. This finding reveals a greater layer of complexity in signaling within brain reward circuits than had previously been recognized.

Deficits in brain reward pathways can produce an inability to derive pleasure from natural stimuli, causing the substance user to focus on obtaining the drug at the expense of work, school, or relationships. Because dysfunctional processing of natural reward is also involved in a variety of mood disorders, a better understanding of these circuits could also have implications for other mental health conditions – including depression.

For a copy of the article, published in Nature Neuroscience, go to: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3945.html. To learn more about research being conducted at NIDA in this area, go to: http://irp.drugabuse.gov/Morales.php.

Contact:
NIDA Press Office
301-443-6245
media@nida.nih.gov

About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at www.drugabuse.gov, which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@nida.nih.gov. Online ordering is available at drugpubs.drugabuse.gov. NIDA’s media guide can be found at www.drugabuse.gov/publications/media-guide/dear-journalist, and its easy-to-read website can be found at www.easyread.drugabuse.gov. You can follow NIDA on Twitter and Facebook.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH. . .Turning Discovery Into Health®

News Releases

Mar 2017

Feb 2017

Dec 2016

Nov 2016

Oct 2016

Sep 2016

Aug 2016

Jul 2016

Jun 2016

May 2016

Apr 2016

Mar 2016

Feb 2016

Jan 2016

Dec 2015

Nov 2015

Oct 2015

Sep 2015

Aug 2015

Jul 2015

Jun 2015

May 2015

Apr 2015

Mar 2015

Feb 2015

Jan 2015

Dec 2014

Nov 2014

Oct 2014

Sep 2014

Aug 2014

Jul 2014

Jun 2014

May 2014

Apr 2014

Mar 2014

Feb 2014

Jan 2014

Dec 2013

Nov 2013

Oct 2013

Sep 2013

Aug 2013

Jul 2013

Jun 2013

May 2013

Apr 2013

Mar 2013

Feb 2013

Jan 2013

Dec 2012

Nov 2012

Oct 2012

Sep 2012

Aug 2012

Jul 2012

Jun 2012

May 2012

Apr 2012

Mar 2012

Feb 2012

Jan 2012

Dec 2011

Nov 2011

Oct 2011

Sep 2011

Aug 2011

Jul 2011

Jun 2011

May 2011

Apr 2011

Mar 2011

Jan 2011

Dec 2010

Nov 2010

Sep 2010

Aug 2010

Jul 2010

May 2010

Apr 2010

Mar 2010

Jan 2010

Get this Publication

    Cite this article

    APA style citation

    NIDA (). NIDA researchers discover further complexity in brain reward circuitry. Retrieved , from https://www.drugabuse.gov/news-events/news-releases/2015/02/nida-researchers-discover-further-complexity-in-brain-reward-circuitry

    press ctrl+c to copy
    Receive Latest Science Articles in your Email!
    You will only receive messages related to Latest Science