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Your search for Relapse and Recovery returned 49 results. Search again.

Basic Science

New Insight Into How Cues Cause Relapse to Cocaine

A brain response occurs in the nucleus accumbens when rats encounter a cue that they associate with previous cocaine self-administration, but not a cue associated with a pleasurable non-drug experience. Moreover, the response correlates in time and intensity with the animals’ cue-induced relapse to cocaine-seeking.

Treatment

Naltrexone Implant Outperforms Daily Pill in Russian Trial

More than half of heroin-addicted patients treated with naltrexone via an implanted delivery device maintained abstinence throughout a 6-month clinical trial in Saint Petersburg, Russia. The implant device, which releases a steady dose of naltrexone continuously for 2 months, averted relapse to heroin use three times as effectively as daily oral doses of the medication.

Prevention

After Release, Jail Inmates’ Substance Use Patterns Relate to Their Choice of Friends

When the goal is to avoid using alcohol and illicit substances after being released from jail, it’s who one’s friends are that counts most. Self-control is important because it helps a person have the right kind of friends.

Treatment

N-Acetylcysteine Postsynaptic Effect Limits Efficacy

Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

Treatment

Animation: Building an Anti-Drug Vaccine

The immune system has an extraordinary ability to recognize compounds foreign to the body and eliminate them. NIDA-sponsored scientists are working to harness this ability to create vaccines that will protect individuals against the psychogenic and addictive effects of abused drugs. This animation shows one of the most promising strategies, which has already yielded partial success in producing effective vaccines against nicotine, cocaine, and other drugs.

Prevention

Desire to Smoke Subsides, But Cigarette Cues Retain Power

During early abstinence, smokers’ cravings triggered by cigarette cues intensified over time, providing evidence that people can experience a phenomenon previously observed in experiments with animals

Basic Science

Cognitive Strategy Reduces Craving by Altering Brain Activity

While viewing images of cigarettes, smokers reported milder cravings when they shifted their focus from the pleasures of smoking to its harmful effects. Brain imaging showed a correlation between the reductions in craving and altered activity levels in regions associated with emotional regulation and reward.

Basic Science

Physical Activity Reduces Return to Cocaine Seeking in Animal Tests

Two independent animal studies suggest that aerobic exercise might help cocaine abusers establish and maintain abstinence.

Basic Science

Molecular Alterations of DNA Contribute to Persistence of Memory

In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.
Basic Science

Disruption of Neuron Production in Adult Rats Increases Cocaine Taking

Drug abuse may diminish production of new neurons in the brain’s hippocampus and thereby increase vulnerability to drug addiction.
Basic Science

Neuropeptide Promotes Behaviors Tied to Addiction and Overeating

Reports on several studies implicating a certain neuropeptide (a signaling molecule) in fostering addition and overeating and discusses implications for addiction treatment.

Treatment

Treatment Dropout Linked With Elevated Stress Response

Summarizes a study to determine whether a stress-related biological marker in saliva can predict how long a drug user will remain in treatment.

Treatment

Medication Reduces Rats' Return to Methamphetamine Seeking

Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

Treatment

Brain Responds to Marijuana Cues in Familiar Manner

Researchers found that the brain activity that takes place when cues trigger marijuana cravings is similar to the activity that accompanies cravings for other drugs.
Treatment

Study Supports Methadone Maintenance in Therapeutic Communities

Describes a study that examined the effectiveness of combining two therapies for drug abuse addiction: methadone treatment and therapeutic communities, two approaches that are rarely combined.

Director's Perspective

Incentives Promote Abstinence

Explores research findings on the value of motivational incentives to promote and reinforce abstinence from substances of abuse and encourage healthy behaviors.

Bulletin Board

Program Enhances Physician Knowledge on Substance Abuse

Reports on an evaluation of the Chief Resident Immersion Training (CRIT) program to assess its effectiveness in improving knowledge, confidence, and preparedness to diagnose, manage, and teach about substance abuse.
Treatment

Deep Brain Stimulation Reduces Rats' Cocaine Seeking

Describes results from an animal study involving deep brain stimulation that holds promise as a therapy for severe cocaine addiction.
Treatment

Intervention Improves Abstinence, Employment Among Welfare Recipients

Reports research to study the effectiveness of an intensive case management program to aid female substance abusers who receive welfare in staying off drugs and finding employment.
Director's Perspective

New Tools and Strategies to Bolster Behavioral Therapy

Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

Treatment

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.
Basic Science

Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.
Treatment

Young Opioid Abusers Benefit From Extended Buprenorphine-Naloxone Treatment

Reports on a study investigating the benefits of extended opioid maintenance therapy that included drug counseling and 12 weeks of therapy with buprenorphine and naloxone.
Treatment

Report Discusses Co-Occurrence of Drug Abuse and Other Mental Disorders

Describes an updated report on the co-occurrence, or comorbidity, of substance use disorders and other psychiatric disorders such as ADHD, schizophrenia, and depression.

Treatment

Recovery Checkup System Helps Substance Abusers Who Have Mental Disorders

Reports on a posttreatment intervention to support recovery that may be especially beneficial for substance abusers with co-occurring mental disorders.

Treatment

Recovery May Be Harder for Adolescents, Animal Study Suggests

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

Treatment

Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.

Treatment

Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

Basic Science

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Treatment

Methadone Therapy in Prison Benefits Men a Year Out

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

Basic Science

Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

Treatment

Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

Treatment

Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Basic Science

Cocaine Locks Rats Into Unrewarding Behaviors

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Director's Perspective

New Vaccines Are Being Developed Against Addiction and Relapse

Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

Prevention

High-Risk Drug Offenders Do Better With Close Judicial Supervision

Reports on research showing that increasing the mandatory drug court monitoring sessions for high-risk drug offenders can enhance program success rates.

Treatment

Lofexidine May Enhance Naltrexone Efficacy

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

Treatment

Aripiprazole Prevents Rats From Resuming Cocaine Seeking

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

Treatment

New Therapy Reduces Drug Abuse Among Patients With Severe Mental Illness

Describes a new intervention that enhances recovery prospects for substance abusers whose mental illness complicates the path toward recovery.

Bulletin Board

Social Neuroscience Meeting Aims To Improve Prevention, Treatment

Presents highlights of a meeting of scientists and clinicians to review research results from the field of social neuroscience, the study of how neurobiology and the social environment interact.

Chronic Cocaine Abusers Have Occult Insomnia in Early Abstinence

Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.

Combination Treatment Extends Marijuana Abstinence

Describes research investigating the use of a treatment that combines vouchers and cognitive behavioral therapy as compared with the use of either treatment alone for marijuana abuse.
Bulletin Board

NIDA Investigator Receives 2006 Waletzky Memorial Award

Announces the recipient of a 2006 award for innovation in research on drug addiction and alcoholism, Dr. Yavin Shaham, and describes his research which focused on the stress-induced drug use relapse.

Serotonin System May Have Potential as a Target for Cocaine Medications

Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.
NIDA @ Work

How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.
Bulletin Board

Walk the Line Is Among 10th Annual PRISM Awardees

Announces the winners of the 10th Annual PRISM Awards, including Walk the Line, a film portraying the life of singer Johnny Cash and his battle with drug addiction.

Low-Cost Incentives Improve Outcomes in Stimulant Abuse Treatment

Reports on a study investigating the use of incentives in the form of prizes to motivate outpatients to stay in behavioral therapy and remain drug free.

Study Finds Withdrawal No Easier With Ultrarapid Opiate Detox

Presents findings from a clinical trial comparing ultrarapid, anesthesia-assisted detoxification with detoxification by traditional methods among patients addicted to heroin.
NIDA Notes

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