Welcome
The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 23-24, 2024 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.
Registration and Meeting support information
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
9:15 a.m. - 9:30 a.m. | Lauren | Wills | Lauren.Wills@mssm.edu | HIV infection enhances the addiction-related actions of opioids: Brain substrates and cellular mechanisms |
9:30 a.m. - 9:45 a.m. | Dong-Wook | Kim | dongwook.kim@alleninstitute.org | Characterization of Single cell multiomic changes during chronic HIV infection and cocaine self-administration in mice |
9:45 a.m. - 10:00 a.m. | Brian | Herb | bherb@som.umaryland.edu | Comparative single-cell multi-omic atlases of molecular adaptations associated with substance use and HIV infections in the prefrontal cortex and nucleus accumbens of humans, non-human primates, and rodents |
10:00 a.m. - 10:15 a.m. | Raleigh | Linville | linville@mit.edu | Cellular taxonomy of the human and mouse striatum defines novel neuronal subtypes in opioid and antipsychotic action |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
9:15 a.m. - 9:30 a.m. | Robert | Loughnan | rloughnan@ucsd.edu | Opportunities and Challenges in Studying Genetic Risk for Substance Abuse in the ABCD Study |
9:30 a.m. - 9:45 a.m. | Hermine H. | Maes | hermine.maes@vcuhealth.org | Estimating twin heritability and environmental sources of variation in the ABCD Study. |
9:45 a.m. - 10:00 a.m. | Jill | Rabinowitz | jr1919@rutgers.edu | Associations of Neural and Genetic Characteristics with Substance Use Risk in the Adolescent Brain Cognitive Development Study |
10:00 a.m. - 10:15 a.m. | Alexander | Hatoum | ashatoum@wustl.edu | 2.) Phenome Wide Association Study of Polygenic Risk Scores for Substance Use Disorders in The Adolescent Brain and Development Study |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1:45 p.m. - 2:00 p.m. | Janitza L. | Montalvo-Ortiz | janitza.montalvo-ortiz@yale.edu | Accelerating psychiatric genetics research in Latin American populations: Consortia efforts and Novel findings |
2:00 p.m. - 2:15 p.m. | Peter | Barr | peter.barr@downstate.edu | The impact of social and genetic risk factors on the onset of comorbid problems in persons with substance use disorders. |
2:15 p.m. - 2:30 p.m. | Emma | Johnson | emma.c.johnson@wustl.edu | 1.) Phenotypic and genomic relationships between chronic pain and substance use disorders in the All of Us biobank |
2:30 p.m. - 2:45 p.m. | Rodney | Gabriel | ragabriel@health.ucsd.edu | Predicting Development of Opioid Use Disorder Among Chronic Pain Patients Using Genomics, Social, and Clinical Factors within the All of Us Research Dataset |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1:45 p.m. - 2:00 p.m. | Yi | Zhang | yzhang@genetics.med.harvard.edu | Identifying and characterizing neuron subtypes and circuits regulating SUD |
2:00 p.m. - 2:15 p.m. | Mary Kay | Lobo | mklobo@som.umaryland.edu | Cell subtype transcriptional programs in cocaine intake and seeking behavior |
2:15 p.m. - 2:30 p.m. | Ana-Clara | Bobadilla | ac.bobadilla@colostate.edu | Differential genetic expression within reward-specific ensembles in mice |
2:30 p.m. - 2:45 p.m. | Veronica A. | Alvarez | alvarezva@mail.nih.gov | Transcriptomic Landscape of Compulsive-like Alcohol Drinking |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
3:00 p.m. - 3:05 p.m. | Elissa | Chesler | Elissa.Chesler@jax.org | Integrative mouse genetic analysis illuminates human GWAS of multiple substance use. |
3:05 p.m. - 3:10 p.m. | Michael | Garvin | garvinmr@ornl.gov | Genetic Loci Associated with Cocaine Use Identified using Novel Approach to Detect Epistasis |
3:10 p.m. - 3:15 p.m. | Vivek | Kumar | Vivek.Kumar@jax.org | Forward genetic screen of the KOMP2/IMPC resource identifies addiction mutants |
3:15 p.m. - 3:20 p.m. | Zhana | Duren | zduren@clemson.edu | Inferring gene regulatory networks from single cell multiome data using atlas-scale external data |
3:20 p.m. - 3:25 p.m. | John | Hernandez | john_hernandez@brown.edu | Single nuclei transcriptomics of the Drosophila mushroom body |
3:25 p.m. - 3:30 p.m. | J Spencer | Hatfield | jshatfi@clemson.edu | Genome-wide Association Analysis of Cocaine Preference in Drosophila |
3:30 p.m. - 3:35 p.m. | Sergei | Grigoryev | sag17@psu.edu | Cryo-electron tomography reveals the inner structure of nucleosome condensates in chromatin of epigenetically modified mouse retina |
3:35 p.m. - 3:40 p.m. | Andy | Chen | andychen@iu.edu | Functional Screening of Regulatory Variants Combined with Genome-wide Association and Machine Learning Identifies Causal Regulatory Mechanisms Impacting Substance Use Disorders |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
9:35 a.m. - 9:50 a.m. | Yunlong | Liu | yunliu@iu.edu | Roles of alternative splicing in alcohol use disorder |
9:05 a.m. - 9:20 a.m. | Duan | Liu | liu.duan@mayo.edu | Neuron-specific RNA-binding Protein ELAVL2 and Post-transcriptional Gene Regulation in Substance Use Disorders |
9:20 a.m. - 9:35 a.m. | Huiping | Zhang | huipingz@bu.edu | RNA N6-methyladenosine modifications in the mesolimbic dopamine system of subjects with alcohol use disorder |
9:50 a.m. - 10:05 a.m. | Katie | Rothamel | krothamel@health.ucsd.edu | Advancing RBP Research: Scalable Tools for Protein-RNA Interaction Analysis |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
9:05 a.m. - 9:20 a.m. | Rong | Xu | rxx@case.edu | Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses |
9:20 a.m. - 9:35 a.m. | Roy | Perlis | RPERLIS@mgh.harvard.edu | Uses and misuses of machine learning for electronic health records |
9:35 a.m. - 9:50 a.m. | Alexander | Hatoum | ashatoum@wustl.edu | 3.) Machine learning Predictors of Substance Use disorder using Genetics Need Control for Ancestry |
9:50 a.m. - 10:05 a.m. | Travis | Mallard | tmallard@mgh.harvard.edu | Characterizing the Genetic Architecture of Impulsivity and its Overlap with Substance Use and Psychopathology |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1:15 p.m. - 1:30 p.m. | Alexander | Smith | smitaw@musc.edu | A master regulator of opioid reward in ventral prefrontal cortex |
1:30 p.m. - 1:45 p.m. | Tamara | Markovic | tamara.markovic@mssm.edu | Modulating levels of ∆FOSB alters nucleus accumbens medium spiny neurons activity to salient stimuli. |
1:45 p.m. - 2:00 p.m. | Sasha | Fulton | slf2127@columbia.edu | Multi-omic single-nucleus characterization of orbitofrontal cortex after cocaine self-administration |
2:00 p.m. - 2:15 p.m. | Kristen | Maynard | Kristen.maynard@libd.org | Multi-omic approaches for molecular mapping of reward circuitry in the human brain |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1:15 p.m. - 1:30 p.m. | Julia (Kate) | Brynildsen | jbryn@seas.upenn.edu | Gene coexpression patterns predict opiate-induced brain-state transitions |
1:30 p.m. - 1:45 p.m. | Ming-Fen | Ho | ho.mingfen@mayo.edu | Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder |
1:45 p.m. - 2:00 p.m. | Susan | Ribeiro | susan.pereira.ribeiro@emory.edu | Methamphetamine Use in People with HIV on Antiretroviral Therapy is Associated with Elevated Systemic Inflammation and HIV Reservoir Transcription |
2:00 p.m. - 2:15 p.m. | Bo | Zhang | bzhang29@wustl.edu | Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats |
Time | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
4:00 p.m. - 4:05 p.m. | Rahul | D'Mello | Rahul dmello@ohsu.edu | Prenatal THC Exposure Alters the Offspring Methylome, Neurodevelopment, and Emotional Behavior |
4:05 p.m. - 4:10 p.m. | Anna | Leonard | anna.leonard@pennmedicine.upenn.edu | Alternative splicing in a mouse model of Oprm1 A118G |
4:10 p.m. - 4:15 p.m. | Alice K. | Min | alice.min@mountsinai.org | Genetically Modified Human iPSC-Derived Microglia in a Chimeric Mouse Model for Studying CNS HIV-1 Infection and Drug Use |
4:15 p.m. - 4:20 p.m. | Dongbing | Lai | dlai@iu.edu | Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations |
4:20 p.m. - 4:25 p.m. | Nana | Amissah | nanaamis@buffalo.edu | Genome wide association studies in heterogeneous stock rats identify links between cue-reactivity and cocaine motivation. |
4:25 p.m. - 4:30 p.m. | Jason | Bubier | Jason.Bubier@jax.org | One of these things is not like the others: Genetic Variation in Morphine and Fentanyl Response in Mice. |
4:30 p.m. - 4:35 p.m. | Drew D. | Kiraly | dkiraly@wakehealth.edu | Gut-brain signaling as a modulator of brain chromatin structure and gene expression in models of substance use disorder. |
4:35 p.m. - 4:40 p.m. | Ying-Xian | Pan | yx.pan@rutgers.edu | 2.) Mitigating adverse side effects of clinically used mu opioids by targeting exon 7-associated splice variants of the mu opioid receptor gene, Oprm1, without altering mu opioid analgesia in pain management |
Poster Number | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1 | Hannah | Alton | hannah.alton@nih.gov | Revisiting the cannabinoid-opioid interaction hypothesis using conditional CB1 and µ opioid receptor knockout mice |
2 | Bradley E. | Aouizerat | bea4@nyu.edu | Piercing the veil of how substance use negatively impacts comorbidities in HIV |
3 | Babak | Baban | bbaban@augusta.edu | Epigenetic effects on substance abuse through immune re-modelling |
4 | Svitlana V. | Bach | svitlana.bach@libd.org | Molecular profiling of the human nucleus accumbens with spatial and single nucleus resolution |
5 | Jared | Bagley | jbagley@binghamton.edu | Polygenic risk for extreme cocaine intake associates with larger dopaminergic responses to cocaine in the nucleus accumbens of BXD inbred mice |
6 | Ludmila | Bakhireva | lbakhireva@salud.unm.edu | Diagnostic Utility of miRNA Signature in Umbilical Cord Blood for Identification of Severe Neonatal Opioid Withdrawal Syndrome |
7 | Britahny M. | Baskin | b.baskin@northeastern.edu | Spontaneously Hypertensive Rat substrains and the offspring of reciprocal F2 crosses exhibit differences in addiction risk traits and cocaine behavioral sensitivity |
8 | Malia | Bautista | maliarb@uci.edu | The Missing Lynx: The Role of Lynx2 in Nicotine Relapse |
9 | Andrew W. | Bergen | awbergen2@gmail.com | Stable Methadone Dose, Toxicology & Treatment Retention in New Jersey MAT |
10 | Aritra | Bhattacherjee | Aritra.Bhattacherjee@childrens.harvard.edu | A molecularly and spatially defined prefrontal cortical circuit regulating drug relapse |
11 | Jennifer | Blackburn | Jennifer.blackburn@yale.edu | Multiplex Cytokine Profiling and Single Nuclei RNAseq Reveal Anti-Inflammatory Changes Following Intravenous Δ-9 Tetrahydrocannabinol Administration Among Healthy Participants |
12 | Kenneth | Blum | drd2gene@Gmail.com | Preaddiction Phenotype is Associated with Dopaminergic Dysfunction: Pharmacogenomic Evidence from 88.8M GWAS-Based Samples |
13 | Kasey | Brida | kbrida@uab.edu | Reelin regulates striatal excitability & cocaine reward |
14 | Russell W. | Brown | brown1@etsu.edu | Underlying Mechanisms of the Effects of Nicotine in a Heritable Model of Drug Abuse Vulnerability in Psychosis |
15 | Jason | Bubier | Jason.bubier@jax.org | Host genetics, microbiome composition and addiction/addiction-related behavior in mice |
16 | Cali | Calarco | ccalarco@som.umaryland.edu | Regulation of gene expression in striatal input regions by cocaine self-administration |
17 | Rianne | Campbell | rcampbell@som.umaryland.edu | Cocaine-induced Changes in Gene Expression and Regulation within GABAergic Ventral Pallidum Cell Types |
18 | Nazzareno | Cannella | nazzareno.cannella@unicam.it | Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in NIH Heterogeneous Stock rats. |
19 | Lieselot | Carrette | lcarrette@health.ucsd.edu | Characterization of the whole-brain reactivity and functional connectome associated with analgesia through MOR and KOR agonism. |
20 | Luis FS | Castro-de-Araujo | luis.araujo@vcuhealth.org | Dynamic Growth of ADHD Symptoms in Youth: Estimating Variance Components of Latent Growth Factors and their Associations with Genetic Liabilities to Substance Use and Abuse |
21 | Samar Nasser | Chehimi | samar.chehimi@pennmedicine.upenn.edu | Fentanyl-xylazine interaction induces transcriptional modifications in the nucleus accumbens of Sprague Dawley rats |
22 | Hao | Chen | hchen@uthsc.edu | 1.) Sex and heredity are determinants of oral oxycodone self-administration in 36 Inbred Rat Strains: correlations with behavioral tests of anxiety and novelty-seeking |
23 | Laurens | Holmes, Jr. | lholmes@desu.edu | 1.) DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) Implication in Substance Use Disorders (SUD) in Essential Hypertension |
24 | Youshu | Cheng | youshu.cheng@yale.edu | A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data |
25 | Meghan | Chenoweth | meghan.chenoweth@utoronto.ca | Sex-Dependent Genetic Architecture of Tobacco-Related Biomarkers |
26 | Natasia S. | Courchesne-Krak | ncourchesne@health.ucsd.edu | Phenome-wide association studies of polygenic liability for externalizing in a European cohort reveals sex- and age-differentiated associations with numerous medical outcomes |
27 | Richard | Crist | crist@pennmedicine.upenn.edu | Single nucleus ATAC-seq of the central amygdala reveals patterns of chromatin accessibility associated with the cocaine self-administration rats |
28 | M. Imad | Damaj | m.damaj@vcuhealth.org | Genetic Variation in nicotine withdrawal in mice using reduced complexity cross |
29 | Giordano | de Guglielmo | gdeguglielmo@health.ucsd.edu | Exploring Genetic Influences on Alcohol Use Disorder: A Comprehensive Study of Addiction-like Behaviors in Heterogeneous Stock Rats |
30 | Danielle | Dick | danielle.m.dick@rutgers.edu | Characterizing Addiction Risk Across Development in Large Epidemiological and Population-Based Samples |
31 | Scott R. | Diehl | scott.diehl@rutgers.edu | Strain Differences in Susceptibility to Opioid Side Effects In Female Mice |
32 | Eamonn | Duffy | Eamonn.duffy@colorado.edu | Sex and genetic background influence intravenous oxycodone self-administration in the Hybrid Rat Diversity Panel |
33 | Fang | Fang | ffang@rti.org | Exposure- and genetically driven epigenetic associations with lifetime cannabis use. |
34 | Zoe | Figueroa | zfigu001@ucr.edu | Inflammation driven astrocyte responses during neuroinflammation caused by chronic methamphetamine exposure |
35 | Heidi S. | Fisher | heidi.fisher@jax.org | Identification of strain differences in transcriptional responses to cocaine across stages of drug self-administration in mice with high and low rates of acquisition and extinction |
36 | Bryan C. | Quach | bquach@rti.org | Transcriptomic analyses identify genes mediating frequent cocaine use effects on HIV latent reservoir quantity |
Poster Number | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1 | Xiao-Bing | Gao | xiao-bing.gao@yale.edu | Transcriptomic study reveals changes in gene expressions in the lateral hypothalamic area in socially isolated mice: relevance to drug addiction |
2 | Ivy | Garrenton | igarr001@odu.edu | Dissecting the Etiology of Alcohol Use Disorder by an Integrative Heritable Component Approach |
3 | Henri M. | Garrison-Desany | hgarrisondesany@hsph.harvard.edu | Association of cord blood DNA methylation patterns and scores with prenatal exposure to opioids, cannabis, and polysubstances |
4 | Emma | Gnatowski | gnatowskie@vcu.edu | Mechanisms of Ethanol Anxiolysis: Role of Global Ninein Deletion On Ethanol and Anxiety-Like Behaviors. |
5 | Mikah | Green | mikah.green@som.umaryland.edu | Using a Cas1sf derived system for CRISPR epigenome editing of fentanyl regulated hub genes. |
6 | Nick | Green | greenni@iu.edu | Cell Type-specific Changes in the Caudate Nucleus of Human Postmortem Brains Induced by Alcohol Use Disorder |
7 | Benjamin H. | Grissom | Bgrissom@som.umaryland.edu | A single-cell multi-omic atlas of the ventral pallidum reveals VGLUT1 neuron-specific transcriptional responses in immediate and prolonged forced abstinence from heroin self-administration |
8 | Hongsheng | Gui | hgui1@hfhs.org | Integrative Omics for studying opioid use disorder and suicidality in African Americans |
9 | Peter | Hamilton | Peter.Hamilton@vcuhealth.org | The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations |
10 | Elaine K. | Hebda-Bauer | hebda@med.umich.edu | The Hippocampus and Nucleus Accumbens Show Unique and Shared Gene Expression Patterns in a Selectively Bred Rat Model of Contrasting Temperaments that Impact Drug Use |
11 | Hao | Chen | hchen@uthsc.edu | 2.) Genetic Association of Socially Acquired Nicotine Self-administration in Adolescent Outbred Rats Identifies Candidate Genes Shared with Human Smoking GWAS |
12 | Laurens | Holmes, Jr. | lholmes@desu.edu | 2.) Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Substance Use Disorder (SUD) Implicated in Early Life Stress and Major Depressive Disorder (MDD) Correlation |
13 | Leanne | Holt | leanne.holt@mssm.edu | Astrocytic CREB regulates the transcriptional and behavioral responses to cocaine. |
14 | Christian | Hopfer | Christian.Hopfer@cuanschutz.edu | Using RNA expression from immune-related cell types in blood to better understand potential influences of THC and CBD on human health |
15 | Chukwudike | Igwe | chigwe@iu.edu | Is Gm22068 a novel epitranscriptomic marker for thirdhand vaping exposure? |
16 | Daniel A. | Jacobson | jacobsonda@ornl.gov | Integrating Multi-Omics Data through Multiplex Networks: A Novel Team Science-based Framework for Understanding the Mechanisms Underpinning Substance Use Disorders and Comorbid Neuropsychological Conditions |
17 | Changhoon | Jee | cjee1@uthsc.edu | Positive reinforcement produced by stimulation of dopaminergic neurons in C. elegans. |
18 | J. David | Jentsch | jjentsch@binghamton.edu | Heritable differences in incentive motivation are genetically correlated with the excitability of dopamine release in the nucleus accumbens core of inbred mice |
19 | Emma | Johnson | emma.c.johnson@wustl.edu | 2.) Multi-ancestral genome-wide association study of nicotine dependence reveals strong genetic correlations with other substance use and psychiatric disorders |
20 | Marcus | Kaul | marcus.kaul@medsch.ucr.edu | Chronic, low dose methamphetamine and HIV-1 Tat protein lead to neuronal injury, astrocyte activation and gene expression patterns displaying sexual dimorphism |
21 | Greg | Keele | gkeele@rti.org | Network biology algorithms identify biological pathways underlying cigarette smoking behaviors |
22 | Panjun | Kim | pkim11@uthsc.edu | Enhancer-Promoter interactions in rat prefrontal cortex identified by Hi-C sequencing facilitate functional interpretation of genetic association studies on substance abuse traits |
23 | Brittany | Kuhn | kuhnb@musc.edu | Genome wide association study reveals multiple loci associated with heroin motivation and taking behavior in heterogeneous stock rats |
24 | Lei | Li | Li129@iit.edu | Cross-modal Sensory Integration: A New Strategy for SUD Treatment |
25 | Zichong | Li | zichong.li@gladstone.ucsf.edu | Combinatorial Targeting of HIV Transcription: Impact of Cocaine and Morphine on Latency Reactivation |
26 | Shirelle X. | Liu | liu00459@umn.edu | Common and unique patterns of gene expression and chromatin accessibility in the rat medial prefrontal cortex across different phases of opioid use disorder |
27 | Falk W. | Lohoff | falk.lohoff@nih.gov | Multi-omics analyses of cortical proteome and single cell-type transcriptome identifies novel drug targets for problematic drinking behavior and alcohol use disorder |
28 | Andrew | Lombardi | anlo5057@colorado.edu | Role of GSCAN-Identified Genes in the Astrocytic Response to Nicotine |
29 | Chang | Lu | changlu@vt.edu | Low-input profiling of epigenomic dynamics in mouse brain to understand prolonged synaptic plasticity |
30 | William | Lynch | wlynch@bu.edu | Validating Zhx2 as a candidate gene underlying Oxycodone Metabolite (Oxymorphone) Brain Concentration and Behavior via Gene Editing and -Omics analyses in BALB/cByJ mice |
31 | Makoto | Taniguchi | Taniguch@musc.edu | A long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation |
32 | Min-Ae | Song | Song.991@osu.edu | A Potential Contribution of Acrylonitrile to Accelerated Epigenetic Aging of the Lungs of Smokers |
34 | Vivek | Swarup | vswarup@uci.edu | Unraveling Transcriptomic Dynamics: Interplay of Opioid Use Disorder and Early Life Adversity in Distinct Brain Regions |
Poster Number | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1 | Brion | Maher | brion@jhu.edu | Brain Differential Methylation and Gene Expression following Opioid Overdose |
2 | Lisa | Maturin | lmaturin@health.ucsd.edu | The Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration. |
3 | Maria | Mavrikaki | mmavrika@bidmc.harvard.edu | Effects of oxycodone self-administration on gene and microRNA expression |
4 | Nicola | Micali | nicola.micali@yale.edu | Defining the effects of prenatal cannabinoid exposure on primate fetal brain development |
5 | Sophia | Miracle | smiracle@bu.edu | Effects of Zhx2 liver and brain overexpression on oxymorphone metabolite levels and state-dependent oxycodone reward learning in BALB/cJ mice with a Zhx2 loss-of-function variant |
6 | Amy | Moore | almoore@rti.org | Leveraging the All of Us Research Program to Better Understand the Genetic Architecture of Opioid Use Disorder Spectrum Behaviors |
7 | Anna | Moszczynska | ei2744@wayne.edu | Ubiquitin-Protein Ligase Parkin in Methamphetamine Use Disorder |
8 | Kateryna | Murlanova | kmurlano@buffalo.edu | Oprm1 deficiency in nucleus accumbens astrocytes increases sensitivity to heroin and reward consumption |
9 | Nathan | Nakatsuka | 08nanaka@gmail.com | A Meta-Analysis Method for Finding Reproducible Differentially Expressed Genes in Single-Cell Transcriptomic Case-Control Studies |
10 | Jesse | Niehaus | jesse_niehaus@med.unc.edu | Accurately quantifying Oprm1 requires an updated gene annotation. |
11 | Steve | Oghumu | oghumu.1@osu.edu | Novel approach for the investigation of X-chromosome inactivation in mice exposed to addictive substances |
12 | Emmanuel | Onaivi | Onaivie@wpunj.edu | Cannabinoid type 2 receptor neuro-immune crosstalk following microglia and dopaminergic neuron specific deletion of CB2Rs. |
13 | Emily | Orr | eorr@wustl.edu | Applying high throughput deep mutational scanning to study transcription factors implicated in the biology of Substance Use Disorders |
14 | Abraham A. | Palmer | aap@ucsd.edu | Prescription Opioids Genetic Study (POGS) an innovative instrument for studying the genetic basis traits relevant to opioid use disorder. |
15 | Yezhi | Pan | ypan@som.umaryland.edu | Nicotine Addiction Functional Networks: A Whole-Brain Connectome Analysis in 24,000 Individuals |
16 | Ying-Xian | Pan | yx.pan@rutgers.edu | 1.) Exploring molecular mechanisms underlying fentanyl overdose-induced toxicities via Oprm1 exon 1-associated variants using tandem mass tag-based phosphoproteomics/proteomics |
17 | Qian | Peng | qpeng@scripps.edu | Genetic Interactions in Alcohol Use Disorder in a High-Risk Population |
18 | Roseann E. | Peterson | roseann.peterson@downstate.edu | Expanded Empirical Population Assignments in Biobanks Empower Ancestrally Inclusive Genetic Studies of Substance Use Disorders |
19 | Chaitanya | Srinivasan | csriniv1@andrew.cmu.edu | Signatures of DNA Damage and Epigenetic Erosion in Opioid Use Disorder |
20 | Vivek M. | Philip | vivek.philip@jax.org | Systems genetics and genomics data resources from the Center for Systems Neurogenetics of Addiction |
21 | Marta | Pratelli | mpratelli@ucsd.edu | 1.) Dopamine-induced change in transmitter phenotype is a shared mechanism for drug-induced generation of cognitive deficits |
22 | Elizabeth | Yen | elizabeth.yen2@tuftsmedicine.org | 1.) Insulin Sensitivity and Body Composition Effects of Prenatal Opioid Exposure |
23 | Andrea D. | Raymond | adraymon@fiu.edu | Modulation of microRNA profiles in extracellular vesicles by HIV infection and opiates |
24 | Walker | Rogers | rogersw@vcu.edu | Investigating Transcriptomic Responses to Ethanol Analgesia Over Time in C57Bl/6J And DBA/2J Mouse Lines |
25 | Cheryl | Rosenfeld | RosenfeldC@missouri.edu | A Novel Single Nuclei Sequencing Approach to Examine Effects of Oxycodone on Parietal Trophoblast Giant Cells in the Mouse Placenta |
26 | Pavana | Rotti | protti@wi.mit.edu | Variant Enhancer Loci (VEL) due to Opioid Overdose Impact Forebrain Neuronal Function |
27 | Laura | Saba | Laura.Saba@cuanschutz.edu | Cell-type specific genetic effects and changes due to oxycodone exposure in RNA expression levels and co-expression networks in rat prefrontal cortex |
28 | Sandra | Sanchez-Roige | sanchezroige@ucsd.edu | Characterizing cases and controls for opioid use disorders using electronic health records: a phenomic and genomic exploration in over 1 million individuals |
29 | Pietro Paolo | Sanna | psanna@scripps.edu | Drug self-administration in a rodent model of HIV: from RNA-Seq to druggable targets. |
30 | Kirti | Sharma | sharmki@iu.edu | One person's nicotine addiction may affect another person's liver |
31 | Jakob (Koby) | Shaykin | k.shaykin@uky.edu | Genomic Assessment of the Prefrontal Cortex in Differential Responsivity of Sucrose Preference and Fentanyl Escalation in Sprague-Dawley Rats |
32 | Michael | Sheldon | Michael.Sheldon@sampled.com | The NIDA, ABCD, HBCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans |
33 | Jeremy | Sherman | jeremy.sherman@icahn.mssm.edu | Multimodal RNA-sequencing of the dorsal striatum identifies a link between H3K27 dysregulation and neurodegenerative phenotypes in heroin use. |
34 | Stephanie | Sillivan | stephanie.sillivan@temple.edu | Integrated analysis of sex-specific regulation of RNA networks in the rat orbitofrontal cortex following heroin self-administration |
35 | Gabriella | Silva | silvag2@vcu.edu | A zinc finger transcription factor in the nucleus accumbens regulates cocaine-induced transcription and behaviors in a cell type specific manner |
36 | N. Dalton | Fitzgerald | ndf@uab.edu | Neuronal activation by cocaine varies across molecularly-defined subpopulations of VTA dopamine neurons |
Poster Number | First Name | Last Name | Abstract Title | |
---|---|---|---|---|
1 | Madhurbain | Singh | singhm18@vcu.edu | Putative Proximal and Distal Effects between Smoking and Alcohol Consumption: Causal Inference from Models Integrating Polygenic Scores with Longitudinal Data |
2 | Omar | Soler-Cedeno | omar.soler-cedeno@nih.gov | Dissecting the functional roles of GABAergic vs. glutamatergic neurons in opioid reward using conditional mu opioid receptor-knockout mice |
3 | Jung Soo | Suk | jsuk@som.umaryland.edu | Combination of focused ultrasound and long-circulating nanoparticles for nucleic acid delivery to the brain |
4 | Kyle | Sullivan | sullivanka@ornl.gov | Multi-omic integration uncovers biological pathways underlying HIV viral load |
5 | Jing | Sun | jsun54@jhmi.edu | Reduced level of circulating cell-free nuclear and mitochondrial DNA fragments among Persons who Inject Drugs with HIV |
6 | Lisa | Tarantino | lisat@med.unc.edu | Repeated exposure to cocaine produces strain specific differences in incentive sensitization in Collaborative Cross mice |
7 | Zachary | Tatom | tatomz@vcu.edu | Car8 knockout in prefrontal cortex increases voluntary ethanol consumption in male mice |
8 | Francesca | Telese | ftelese@ucsd.edu | TSS-MPRA to decode regulatory functions of genetic variants associated with substance use disorders. |
9 | Stella | Tommasi | tommasi@med.usc.edu | Epigenomic dysregulation in youth vapers: implications for disease risk assessment |
10 | Guy | Twa | gtwa@uab.edu | Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns |
11 | Mudit | Tyagi | Mudit.Tyagi@jefferson.edu | Cocaine enhances HIV infection, gene expression and replication by stimulating cell metabolism |
12 | Alp Mete | Umnet | aummet@clemson.edu | Variation in Mushroom Body Morphology in Cocaine Preferring Drosophila Genetic Reference Panel Lines |
13 | Mary-Elizabeth | Zipparo | mzippar1@jhmi.edu | Past cocaine exposure durably alters CD4+ T-cell reservoir seeding and reactivation SIV-infected ART-suppressed macaques |
14 | Avinash | Veerappa | aveerappa@unmc.edu | OMICS Perspectives Unveil Neural Circuitry Adaptations in Chronic Heroin Addiction: A Genome-Wide Analysis of Epigenetic Signatures and Transcriptional Programs |
15 | Thao | Vu | thao.3.vu@cuanschutz.edu | Identification of blood metabolite biomarkers for oxycodone exposure in rats through metabolomics |
16 | Haohan | Wang | haohanw@illinois.edu | Understanding Variations in Regulatory Networks Across Cell Types through Transformer Model with Knowledge on Regulatory Interactions |
17 | Bradley T. | Webb | bwebb@rti.org | Deep ascertainment and genetic architecture of alcohol use disorder and related outcomes in All of Us. |
18 | Julie | White | jdwhite@rti.org | Comparison of DNA methylation signals across substances reveals shared biological implications for substance use |
19 | Caryn | Willis | cdwillis@rti.org | Meta-analyses of gene expression differences associated with alcohol use disorder in human brain |
20 | Kelly | Wingfield | kelwing@bu.edu | Exploring mouse ultrasonic vocalizations as a tool to study negative affective states in mice using a mouse model of neonatal opioid withdrawal syndrome (NOWS) |
21 | Zheng-Xiong | Xi | zxi@intra.nida.nih.gov | Neuronal versus glial CB2 receptor: Findings from a new strain of CB2-KO-EGFP reporter mice |
22 | Ke | Xu | Ke.Xu@yale.edu | Epigenome-wide characterization reveals aberrant DNA methylation of host genes regulating CD4+ T cell HIV-1 latent reservoir size in women living with HIV |
23 | Rongguang | Xu | roxu@bwh.harvard.edu | Investigating the Impact of Histone Post-Translational Modifications on Nucleosome Structure and Accessibility: Insights from Molecular Dynamics Studies |
24 | Ege A. | Yalcinbas | ege.yalcinbas@libd.org | Transcriptomic changes in habenula following chronic fentanyl self-administration in rats |
25 | Fengchun | Ye | fxy63@case.edu | Nurr-est neighbors: RXR induces epigenetic silencing of HIV-1 in microglial cells |
26 | Zhenyao | Ye | zye@som.umaryland.edu | Alcohol-Induced Alterations in Brain Functional Connectivity: Insights from Whole-Brain Data-Driven Analysis in Older Adults |
27 | Marta | Pratelli | mpratelli@ucsd.edu | 2.) Pipeline for whole-brain analysis of METH-induced changes in neurotransmitter phenotype |
28 | Elizabeth | Yen | elizabeth.yen2@tuftsmedicine.org | 2.) Molecular Evidence of Sex-Specific Effects in Neonates with Prenatal Opioid Exposure |
29 | Xinxu | Yuan | Xinxu.yuan@vcuhealth.org | All-in-one AAV delivery of multiplexed hypercompact OsCas12f/sgRNAs to eradicate HIV |
30 | Zhuzhu | Zhang | zhuzhuzhang@uchicago.edu | Single-Cell Resolution and Circuit-Level Dissection of Epigenomic Remodeling in Addiction |
31 | Jian | Zhu | jian.zhu@osumc.edu | Contribution of Methamphetamine-Induced Dysregulation of RNA Methylation to Promoting HIV Infection in Microglia/Macrophages |
32 | Lea | Zillich | lea.zillich@zi-mannheim.de | Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus suggests phosphodiesterases as a pharmacological target |
33 | Rajtarun | Madangopal | rajtarun.madangopal@nih.gov | In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2 |
34 | Katherine | Savell | Katherine.savell@nih.gov | Cell-type-specific transcriptional signatures of cocaine relapse in the rat medial prefrontal cortex |
- May 2023 Meeting
Welcome
The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.
Meeting Dates and Times
- Tuesday, May 16th: - 9:00 a.m. to 5:30 p.m.
- Wednesday, May 17th - 9:00 a.m. to 5:00 p.m.
Agenda and Meeting Abstracts
May 16 – Keynote (9:15 am – 9:45 am) Time First Name Last Name Email Abstract Title 9:15 Andre Toussaint at3658@columbia.edu Understanding Substance Abuse from Scientific and Human Perspectives May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs Time First Name Last Name Email Abstract Title 9:45 Kristen Maynard kristen.maynard@libd.org Integrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain 10:00 Marine Salery marine.salery@mssm.edu Capturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens. 10:15 Jennifer Tuscher jtuscher@uab.edu Multiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience 10:30 Benjamin Reiner bcreiner@pennmedicine.upenn.edu Single nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine May 16 – Special Presentation (11:00 am – 11:10 am) Time First Name Last Name Email Abstract Title 11:00 Anita Bandrowski bandrow@gmail.com RRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs Time First Name Last Name Email Abstract Title 2:00 Carl Lin zlin@mclean.harvard.edu History and Application of Artificial Intelligence: Its Turn for Genomics 2:00 Sara Mostafavi saramos@cs.washington.edu Sequence-based deep learning models for predicting molecular phenotypes 2:15 Hongyang Li Hongyang.Li@ibm.com Asymmetric Predictive Relationships Across Histone Modifications 2:30 Andreas Pfenning apfenning@cmu.edu Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs Time First Name Last Name Email Abstract Title 9:00 Elizabeth Heller eheller@pennmedicine.upenn.edu Cocaine regulation of alternative splicing via changes in histone postranslational modifications. 9:15 Zijun Wang zjwang@ku.edu DNA damage and repair processes are involved in opioid addiction 9:30 Zhuzhu Zhang zhuzhuzhang@uchicago.edu Epigenomic remodeling at single cell resolution in cocaine self-administration in mice 9:45 BaDoi Phan badoi.phan@pitt.edu Whole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs Time First Name Last Name Email Abstract Title 1:15 Holly Poore holly.poore@rutgers.edu Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders 1:30 Sandra Sanchez-Roige sanchezroige@ucsd.edu CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice 1:45 Huda Akil akil@umich.edu Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol. 2:00 Michael Sheldon michael.sheldon@sampled.com Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse Abstracts From Those Unavailable to Present First Name Last Name Email Abstract Title Li-Shiun Chen li-shiun@wustl.edu Roadmap for translating genomic evidence to clinical interventions for prevention and treatment Ditte Demontis ditte@biomed.au.dk Elucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS Desmond Smith DSmith@mednet.ucla.edu Cocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice