Drugs of abuse are able to interfere with this normal communication process in the brain. Cocaine, for example, blocks the removal of dopamine from the synapse by binding to the dopamine transporters. As shown in this image, this results in a buildup of dopamine in the synapse. In turn, this causes a continuous stimulation of receiving neurons, probably responsible for the euphoria reported by cocaine abusers.
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NIDA (2016). Understanding Drug Abuse and Addiction: What Science Says. Retrieved , from https://www.drugabuse.gov/understanding-drug-abuse-addiction-what-science-says
Explores the consequences of drug abuse on the brain and body and introduces the topics of prevention, and treatment.