4: Opiates binding to opiate receptors in the nucleus accumbens: increased dopamine release
This is a close-up view of a synapse in the nucleus accumbens. Three types of neurons participate in opiate action: one that releases dopamine (on the left), a neighboring terminal (on the right) that contains a different neurotransmitter (probably GABA for those who would like to know), and the post-synaptic cell that contains dopamine receptors (in pink). Show that opiates bind to opiate receptors (yellow) on the neighboring terminal and this sends a signal to the dopamine terminal to release more dopamine. [In case someone asks how, one theory is that opiate receptor activation decreases GABA release, which normally inhibits dopamine release, so dopamine release is increased.]
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NIDA (2007). The Neurobiology of Drug Addiction. Retrieved , from https://www.drugabuse.gov/publications/teaching-packets/neurobiology-drug-addiction
Explores the consequences of drug abuse on the brain and body and introduces the topics of prevention, and treatment.