15: Overall summary: these drugs of abuse all activate the reward system via increasing dopamine neurotransmission
In this last slide, the binding of all 3 drugs is shown in one of the reward areas, the nucleus accumbens. Summarize that each drug increases the activity of the reward pathway by increasing dopamine transmission. This happens even though the drugs act by different mechanisms. Because of the way our brains are designed, and because these drugs activate a particular brain pathway for reward, they have the ability to be misused.
Start a discussion; ask the students if they can think of any other drugs that are misused that probably activate the reward system in the same way. Answer: alcohol, nicotine, and amphetamine are good examples.
Cite this article
NIDA. (2019, November 19). The Brain & the Actions of Cocaine, Opioids, and Marijuana. Retrieved from https://www.drugabuse.gov/brain-actions-cocaine-opioids-marijuana
Explores the consequences of drug abuse on the brain and body and introduces the topics of prevention, and treatment.