Among other adverse effects, many drugs can cause nausea and vomiting after use. Cocaine use can also cause abdominal pain and bowel tissue decay, and opioid use can cause abdominal pain, acid reflux, and severe constipation.
Drugs that can affect the gastrointestinal system:
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NIDA (2017). Health Consequences of Drug Misuse. Retrieved , from https://www.drugabuse.gov/related-topics/health-consequences-drug-misuse