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National Institute on Drug Abuse to hold teleconference discussing key findings of 2018 Monitoring the Future Survey on teen drug use

December 06, 2018 | News Release
Media Advisory.

The National Institute on Drug Abuse (NIDA) will hold a teleconference on Monday, December 17, to discuss the results of the 2018 Monitoring the Future (MTF) survey.

ABCD study completes enrollment, announces opportunities for scientific engagement

December 03, 2018 | News Release

The National Institutes of Health announced today that enrollment for the Adolescent Brain Cognitive Development (ABCD) Study is now complete and, in early 2019, scientists will have access to baseline data from all ABCD Study participants.

Research suggests benzodiazepine use is high while use disorder rates are low

October 18, 2018 | Science Highlight
A recent analysis suggests that benzodiazepine use disorders are relatively rare among the adults who use benzodiazepine medications, even if they are misusing them.

New opioid treatment resources for emergency department clinicians

October 03, 2018 | News Release

The National Institute on Drug Abuse (NIDA) today announced the availability of informational resources for clinicians interested in initiating buprenorphine treatment in emergency department settings.

Recent Research Sheds New Light on Why Nicotine is So Addictive

September 28, 2018 | Nora's Blog
Nicotine does not produce the kind of euphoria or impairment that many other drugs like opioids and marijuana do. People do not get high from smoking cigarettes or vaping. Yet nicotine’s powerful ability to reinforce its relatively mild rewards results in 480,000 deaths annually.

The HEALing Communities Study: Using Science to Address the Opioid Crisis

September 19, 2018 | Nora's Blog
The public health emergency of opioid misuse and addiction affects millions of Americans and requires innovative scientific solutions. Today, during “National Prescription Opioid and Heroin Awareness Week,” we are sharing news of an important step towards these solutions through the HEALing Communities Study.

How Can We Better Support Physicians in Addressing the Opioid Crisis?

August 31, 2018 | Nora's Blog
Ample evidence shows methadone and buprenorphine reduce overdose deaths, prevent the spread of diseases like HIV, and enable people to take back their lives, but there are restrictions on who can prescribe these medications.

E-Cigs linked to heart attacks

August 27, 2018 | Science Highlight
An analysis of health data concludes that e-cigarette use, adjusted for smoking conventional cigarettes and other risk factors, is associated with increased risk of myocardial infarction, which is commonly known as a heart attack caused by blockage of the arteries.

Pregnant women in Appalachia face barriers to opioid treatment

July 26, 2018 | Science Highlight
A NIDA-funded study has discovered that pregnant women in Appalachia face barriers to receiving medication-assisted treatment for opioid use disorders, from both insurers and providers.

Journal commentary addresses role of dentists in opioid crisis

July 25, 2018 | News Release

The commentary, authored by Dr. Nora Volkow, director of the National Institute on Drug Abuse, and Dr. Martha Somerman, director of the National Institute of Dental and Craniofacial Research, both parts of the National Institutes of Health, highlights how the Institutes are working together to support scientific research for those in clinical practice.

NIH Partners with the Dental Community to Help Curb the Opioid Crisis

July 25, 2018 | Nora's Blog
Reducing healthcare’s reliance on potentially addictive opioid pain relievers has been one of the pillars of federal efforts to reverse the opioid crisis.

New clinician screening tool available for substance use

June 28, 2018 | News Release

The National Institute on Drug Abuse (NIDA) Clinical Trials Network has unveiled a new scientifically validated, online screening tool designed to assess a patient’s risk for substance misuse and substance use disorder, and assist the health care provider with prevention and treatment strategies.

Training module now available for acute pain management in hospitalized adults

June 27, 2018 | News Release
New online course is 10th in a series developed by the NIH Pain Consortium.

A case-based clinician training module designed for the evaluation of acute pain and opioid management for adults is now available through the Centers of Excellence in Pain Education (CoEPE) program, coordinated by the National Institute on Drug Abuse.

Scientists discover path to better pain medicines

June 26, 2018 | Science Highlight
In this this NIDA-funded research, scientists used a novel approach to compare the cell signaling initiated by kappa opioids that produce dysphoria from those that do not.

Analysis of insurance coverage for back pain shows missed opportunities to prescribe non-opioid medications

June 22, 2018 | News Release
Science Spotlight.

A comprehensive analysis of health insurance coverage of non-opioid and opioid medications to treat chronic low back pain concluded that some insurance plans have missed important opportunities to steer patients towards safer and more effective treatments than prescription opioids.

Methadone and buprenorphine reduce risk of death after opioid overdose

June 19, 2018 | News Release
NIH research confirms effective treatments for opioid use disorder are underutilized.

A National Institutes of Health-funded study found that treatment of opioid use disorder with either methadone or buprenorphine following a nonfatal opioid overdose is associated with significant reductions in opioid related mortality.

An Ambitious Research Plan to Help Solve the Opioid Crisis

June 12, 2018 | Nora's Blog
In spring 2018, Congress added an additional $500 million to the NIH budget to invest in science to find solutions to the opioid crisis. The funding that NIDA is receiving will go toward the goal of addressing addiction in new ways and better delivering existing forms of care to populations that need it.

Special journal issue highlights ABCD brain study

June 11, 2018 | News Release

The special issue is an overview of the ABCD Study and includes articles about the rationale for the study, its design and recruitment strategy, assessment protocols and neuroimaging parameters, the inclusion of twins in the research design, biomedical ethics and clinical oversight, and retention considerations, among others.

Too Hot And Too Cold: Dysregulation of key brain networks in people with addiction

June 08, 2018 | Science Highlight
Study suggests that brain activity is not simply too high or low in people who are addicted to drugs, but behaves differently to drug and non-drug stimuli.

Breathing under the influence of … fentanyl

May 30, 2018 | Science Highlight
An animal study at NIDA’s intramural research labs suggests fentanyl-induced respiratory depression affects the temperature of the brain, triggering brain hypoxia and hyperglycemia.

FDA approves first medication to reduce opioid withdrawal symptoms

May 16, 2018 | News Release

Lofexidine, the first medication for use in reducing symptoms associated with opioid withdrawal in adults, has been approved by the U.S. Food and Drug Administration.

What science says about Tobacco + Marijuana + Pregnancy

May 11, 2018 | Science Highlight
A NIDA-funded study suggests that pregnant women who smoke both marijuana and cigarettes have a higher likelihood of smaller babies and increased maternal stress and aggression.

Study upends conventional view of opioid mechanism of action

May 10, 2018 | News Release
NIH-funded scientists find new molecular target for developing safer pain medications.A new discovery shows that opioids used to treat pain, such as morphine and oxycodone, produce their effects by binding to receptors inside neurons, contrary to conventional wisdom that they acted only on the same surface receptors as endogenous opioids, which are produced naturally in the brain.

Understanding the Neuroscience of Addiction: what it means for prevention and treatment

April 25, 2018 | News Release

Advances in the understanding of brain development, as well as the role that genes and environment play in addiction, are the focus of a review article published today in The American Journal of Psychiatry.

Overdose drug shows promise as stroke treatment

April 17, 2018 | Science Highlight
Preclinical research lays the groundwork for developing the first drug to promote recovery from ischemic stroke, a leading cause of adult disability.

Five million American adults misusing prescription stimulants

April 16, 2018 | News Release
Science Spotlight.

Looking at annual averages, approximately 6.6% (or 16 million) of U.S. adults used prescription stimulants in the preceding year; 4.5% (or 11 million) used prescription stimulants appropriately (without misuse); 2.1% (or 5 million) misused prescription stimulants at least once; and 0.2% (or 0.4 million) had prescription stimulant use disorders.

Listening to Patients’ Voices in Developing New Opioid Addiction Treatments

April 05, 2018 | Nora's Blog
One of the pillars of the current federal initiatives to end the opioid crisis is the development of new medications to treat opioid addiction. The FDA Patient-Focused Drug Development Initiative (PFDD), established in 2012, seeks to solicit patient perspectives on which symptoms are most important to target.

Study changes long-held concepts of cell decoding

March 28, 2018 | News Release
NIH scientists discover macromolecular complexes that could enable medication development.

Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body’s hard-working G protein-coupled receptors (GPCRs) than previously thought, suggesting a conceptual advance in the fields of biochemistry and pharmacology.

Study highlights how opioid receptors organize to block pain

March 27, 2018 | Science Highlight
A NIDA-funded study explored how opioids such as morphine act within pain circuits in the brain and spinal cord, while attaching to receptors on the surface of nerve cells (neurons).

Non-psychoactive cannabinoid may enable drug addiction recovery

March 26, 2018 | News Release
Science Spotlight.