Research Highlights

Addressing America’s Fentanyl Crisis

 |  Every day, 91* Americans fatally overdose on an opioid drug. It may be a prescription analgesic or heroin but increasingly it is likely to be heroin’s much more potent synthetic...

Endocannabinoid Regulates Cocaine Reward

 |  Investigators have shown that 2-AG, an endocannabinoid (i.e., a cannabinoid manufactured within the body, as opposed to plant-derived), augments the cocaine-induced dopamine surge in the brain’s reward system. The discovery...

Impacts of Drugs on Neurotransmission

 |  Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between neurons (nerve cells) in the brain. Many scientific studies conducted over decades...

Why Are Our Brains So Big and Powerful?

 |  Why is the human brain so much bigger and more powerful than that of other animals? Researchers have investigated the hypothesis that changes not only in our genes themselves, but...

Promising Advances in the Search for Safer Opioids

 |  Two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids...

Rethinking How We Talk About Addiction

 |  People with substance use disorders and other mental health issues face greater stigma than those with other illnesses. Many of the addiction-related terms widely used in our society—even in the...

Quinine as a Tracer for Medication Adherence

 |  Patients who don’t take their medications or take them other than as prescribed often put themselves at risk for problems including misdiagnoses, complications, and death. The resulting costs to the...