The degree of connectivity of a neuronal network in the rat brain before nicotine exposure can help predict nicotine dependence severity after nicotine exposure as well as reversal of dependence after a period of abstinence.
People’s decisions to use e-cigarettes, as well as perceptions about associated risks, are influenced by the e-cigarettes’ nicotine levels and available flavors. The influence of these characteristics on decision-making and perceived risk differs between people who smoke cigarettes and people who do not smoke.
This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir–targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9 out of 23 mice that received the combination treatment. HIV was not eliminated in any of the mice that were given either treatment alone.
Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.
The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects
This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the program can improve supportive parenting practices as well as reduce the adolescents’ high-risk behaviors, conduct problems, health risks, and risk of continued poverty.