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NIDA Notes Articles: All

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Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients

April 2018
Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics.

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Why Marijuana Displeases

March 2018
This study demonstrated how THC produces aversive effects in mice and suggests a mechanism to explain why people experience rewarding, aversive, or mixed effects from marijuana.

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Long-Term Marijuana Use Is Associated With Health Problems Later in Life

February 2018
Researchers used the statistical technique of latent class analysis to describe distinct patterns of marijuana use across age using data from nearly 10,000 participants in the Monitoring the Future study. Longer-term marijuana use (extending from age 18 into the late 20s or beyond) was associated with increased risk of self-reported health problems at age 50.

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Stressful Experiences Affect Likelihood of Remission of Drug Dependence, Continued Drug Use, and Relapse

February 2018
Stressful life events are associated with reductions in a person’s chances of becoming or remaining abstinent from drugs for at least 3 years.

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A Family-Oriented Intervention May Reduce the Effects of Poverty on Brain Development

January 2018
The parenting-focused Strong African American Families program can ameliorate poverty’s negative effects on limbic brain development.  

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Available Soon: NIDA’s E-Cigarette

January 2018
NIDA and NJOY, LLC, have developed a Standard Research E-Cigarette. The device will help researchers resolve many outstanding questions about how e-cigarettes affect health.

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Anabolic-Androgenic Steroids May Damage the Heart and Arteries

November 2017
Use of anabolic-androgenic steroids (AAS) is associated with compromised heart pumping and atherosclerotic plaque. Clinicians should inquire about AAS use when young or middle-aged men present with left ventricular dysfunction or coronary artery disease.

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Substance Use Disorders Are Associated With Major Medical Illnesses and Mortality Risk in a Large Integrated Health Care System

October 2017
Strong associations exist between substance use disorder diagnoses and 19 major medical illnesses among patients in a large, integrated health care system. The study indicates that these associations may persist even in health care systems that provide specialized treatment for substance use disorders and have capacity to integrate behavioral and medical care.

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Deep Brain Stimulation Attenuates Rats’ Responses to Heroin

October 2017
High-frequency electrical stimulation of neurons deep in the brain can reduce rats’ relapse-like behavior and motivation to take heroin. The finding strengthens hope that deep brain stimulation might offer a new treatment alternative for opioid addiction, particularly for patients who have not benefited from other treatments.

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After Showing Promise for Cannabis-Using Adolescents, N-Acetylcysteine Falters in Adult Study

September 2017
In a clinical trial, N-acetylcysteine did not help adults reduce their cannabis use, despite having been effective for adolescents in a previous trial. The results indicated that if adults are able to benefit from the medication, they will likely require a different treatment regimen than adolescents.

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