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Slow-Release Amphetamine Medication Benefits Patients With Comorbid Cocaine Addiction and ADHD

August 2016

Treatment with an extended-release stimulant medication plus cognitive behavioral therapy was associated with reductions in cocaine use and in attention-deficit/hyperactivity disorder symptoms in patients with both disorders.

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Study Questions Role for Marijuana in Teen Users’ IQ Decline

August 2016

In a recent study, teens who used marijuana lost IQ points relative to their nonusing peers. However, the drug appeared not to be the culprit.

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Narrative of Discovery: Can Magnets Treat Cocaine Addiction? Part 2

July 2016

During investigations into using transcranial brain stimulation (TMS) to treat cocaine abuse, two projects take diverging paths. One researcher moves to the next stage, while another is forced to cut his trial short. 

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Study Links Medical Marijuana Dispensaries to Reduced Mortality From Opioid Overdose

May 2016

Legally protected marijuana dispensaries (LMDs) were associated with lower rates of dependence on prescription opioids, and deaths due to opioid overdose, than would have been expected based on prior trends. However, LMDs also were associated with higher rates of recreational marijuana use and increased potency of illegal marijuana.

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Sensation Seeking Promotes Initiation, Impulsivity Promotes Escalation of Substance Use

May 2016

Teens who avidly seek new and intense sensations are more likely to start using substances, but are not more likely to use them regularly within the next 3 years unless they also are prone to devalue distant consequences and act impulsively.

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Dual Regimen Aims To Shorten Medication-Assisted Therapy

May 2016

Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction, Part 2

April 2016

When lobeline turned out not to be the answer, it became a starting point. Dr. Linda Dwoskin and her team set out to transform the molecule into something more effective and with fewer side effects.

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Testing a Prospective Medication To Help People Avoid Relapse

March 2016

This NIDA Notes animation depicts a basic experiment that researchers use to test whether a prospective new medication can prevent relapse to drug addiction.

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Gene Variant Is Associated With Reduced HIV Transmission

March 2016

A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.

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Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

February 2016

The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

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