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EEG Indicates That Cocaine Relapse Vulnerability Peaks 1 to 6 Months Into Abstinence

September 2017

Electroencephalography (EEG) may provide an objective measure of cocaine-addicted participants’ vulnerability to cue-induced relapse. The assessment of cue-induced responsiveness may be useful in the clinical setting for assessing relapse risk and tailoring interventions to maintain abstinence among cocaine-addicted adults. 

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After Showing Promise for Cannabis-Using Adolescents, N-Acetylcysteine Falters in Adult Study

September 2017

In a clinical trial, N-acetylcysteine did not help adults reduce their cannabis use, despite having been effective for adolescents in a previous trial. The results indicated that if adults are able to benefit from the medication, they will likely require a different treatment regimen than adolescents.

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Blocking Protein Complex May Lock Down HIV Reservoirs

September 2017

Inhibiting mTOR, a regulatory protein complex, can prevent reactivation of latent HIV. Medications to inhibit mTOR might help people with HIV achieve and maintain undetectable HIV viral loads.

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Variation in the Gene for the μ-Opioid Receptor May Influence Responses to Methadone

August 2017

A single nucleotide polymorphism in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.

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Opioid Agonist Treatment Reduces Societal Costs of Crime

August 2017

Patients who initiate time-unlimited opioid-agonist therapy will generate lower average total crime-related costs over the next 6 months than patients who initiate a 21-day detoxification regimen.

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Why Females Are More Sensitive to Cocaine

August 2017

New research demonstrates that the hormone estradiol is responsible for females’ increased sensitivity to stimulant drugs.

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Researchers Speak: The ABCD Study

June 2017

In this video, Dr. Terry Jernigan describes the purpose and goals of the Adolescent Brain and Cognitive Development (ABCD) Study.

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Nonmedical Opioid and Heroin Use Among High School Seniors

April 2017

This study analyzed the use of use of nonmedical opioids and heroin use among 68,000 high-school seniors participating in the NIDA-funded Monitoring the Future Study between 2009 and 2013.

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Narrative of Discovery: Can Magnets Treat Cocaine Addiction? Part 3

March 2017

In the final installment of this series, Dr. Diana Martinez navigates the process for receiving NIH funding to test the efficacy of using transcranial magnetic stimulation as treatment for cocaine addiction.

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Buprenorphine Benefits Waitlisted Seekers of Opioid Treatment

March 2017

In two pilot clinical trials, buprenorphine helped participants reduce their illicit opioid use and injection drug use while awaiting admission to a methadone or buprenorphine treatment program. Researchers minimized the risks for improper use or diversion of the study medication by giving it to trial participants in a computerized, tamper-proof device that dispenses one dose each day.

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