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Antiretroviral Therapy Combined With CRISPR Gene Editing Can Eliminate HIV Infection in Mice

February 2020
This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir–targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9 out of 23 mice that received the combination treatment. HIV was not eliminated in any of the mice that were given either treatment alone.

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Part 2: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

February 2020
Researchers move their monoclonal antibody (mAb) into clinical trials to see if it can be an effective treatment for methamphetamine use.

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Part 1: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

January 2020
Researchers have created a monoclonal antibody (mAb) that is intended to interact with methamphetamine and decrease its ability to enter the brain.

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AOUD Treatment in Primary Care Settings—Is it Feasible?

January 2020
Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.

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A New Era at NIDA Notes

January 2020
As we enter a new year, we would like to honor and thank NIDA Notes Editor David Anderson, who recently retired after 20 years at the helm of NIDA’s signature science publication.

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Novel Dopamine D3 Receptor Antagonist Reduces Opioid Addiction-Like Behaviors in Rats

January 2020
The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects

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The Strong African American Families Program Improves Lives of Rural African American Youth

December 2019
This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the program can improve supportive parenting practices as well as reduce the adolescents’ high-risk behaviors, conduct problems, health risks, and risk of continued poverty.

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α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids

December 2019
In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.

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Nerve-Cell Growth During Abstinence From Methamphetamine May Promote Reinstatement of Drug Use in Rats

November 2019
Neurogenesis that occurs during abstinence from methamphetamine in a brain region related to memory and learning may promote relapse-like behavior.

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Mindful Awareness in Body-Oriented Therapy Proves Useful in Women Treated for Substance Use Disorder

October 2019
Mindful Awareness in Body-Oriented Therapy (MABT) improved emotion regulation, reduced craving, and promoted abstinence in women with a history of trauma and emotional problems receiving outpatient treatment for substance use disorder.

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