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NIDA Notes Articles: All

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As Opioid Use Disorders Increased, Prescriptions for Treatment Did Not Keep Pace

July 2018
Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to staying in treatment.

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Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT

June 2018
A clinical trial found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they maintained this advantage through a 6-month follow-up.

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In Animals, Opioid Combination Shows Promise for Safer Pain Relief

June 2018
In rats, the combination treatment of oxycodone/nalfurafine had lower levels of abuse liability and produced less respiratory depression than oxycodone alone.

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A Gene Links Impulsivity and Drug Use Vulnerability

June 2018
Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.

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Novel Compound Alleviates Hard-to-Treat Pain in Mice

June 2018
A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.

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Cigarette Smoking Increases the Likelihood of Drug Use Relapse

May 2018
Research suggests that helping patients quit and remain abstinent from smoking may improve their chances for sustained recovery from use of other drugs.

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Narrative of Discovery: The Quest for a Medication to Treat Methamphetamine Addiction, Part 3

May 2018
Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first ever medication to treat methamphetamine addiction.

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Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients

April 2018
Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics.

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Why Marijuana Displeases

March 2018
This study demonstrated how THC produces aversive effects in mice and suggests a mechanism to explain why people experience rewarding, aversive, or mixed effects from marijuana.

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Long-Term Marijuana Use Is Associated With Health Problems Later in Life

February 2018
Researchers used the statistical technique of latent class analysis to describe distinct patterns of marijuana use across age using data from nearly 10,000 participants in the Monitoring the Future study. Longer-term marijuana use (extending from age 18 into the late 20s or beyond) was associated with increased risk of self-reported health problems at age 50. En Español

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