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NIDA Notes Articles: All

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Stronger Brain Circuit Connectivity May Predict Nicotine Dependence Severity

March 2020
The degree of connectivity of a neuronal network in the rat brain before nicotine exposure can help predict nicotine dependence severity after nicotine exposure as well as reversal of dependence after a period of abstinence.

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Serotonin Receptor Agonist Lorcaserin Reduces Relapse to Drug Use in Monkeys

March 2020
The serotonin 2C receptor agonist lorcaserin reduced reinstatement of drug-seeking behavior in response to heroin or cocaine in a nonhuman primate model of relapse.

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E-Cigarette Characteristics May Influence Use and Are Potential Targets for Regulatory Policy

March 2020
People’s decisions to use e-cigarettes, as well as perceptions about associated risks, are influenced by the e-cigarettes’ nicotine levels and available flavors. The influence of these characteristics on decision-making and perceived risk differs between people who smoke cigarettes and people who do not smoke.

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Antiretroviral Therapy Combined With CRISPR Gene Editing Can Eliminate HIV Infection in Mice

February 2020
This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir–targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9 out of 23 mice that received the combination treatment. HIV was not eliminated in any of the mice that were given either treatment alone.

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Part 2: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

February 2020
Researchers move their monoclonal antibody (mAb) into clinical trials to see if it can be an effective treatment for methamphetamine use.

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Part 1: Immunotherapies—A New Tool To Treat Methamphetamine Addiction?

January 2020
Researchers have created a monoclonal antibody (mAb) that is intended to interact with methamphetamine and decrease its ability to enter the brain.

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AOUD Treatment in Primary Care Settings—Is it Feasible?

January 2020
Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.

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A New Era at NIDA Notes

January 2020
As we enter a new year, we would like to honor and thank NIDA Notes Editor David Anderson, who recently retired after 20 years at the helm of NIDA’s signature science publication.

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Novel Dopamine D3 Receptor Antagonist Reduces Opioid Addiction-Like Behaviors in Rats

January 2020
The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects

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The Strong African American Families Program Improves Lives of Rural African American Youth

December 2019
This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the program can improve supportive parenting practices as well as reduce the adolescents’ high-risk behaviors, conduct problems, health risks, and risk of continued poverty.

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