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This study demonstrated that cocaine increases expression of the protein E2F3a in the brain’s reward system. The changes in E2F3a levels in the nucleus accumbens are tied to addiction-related behaviors and to altered gene expression.
An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.
Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in the brain.
Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.
March 2016 A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.