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NIDA Notes Articles: Comorbidity and Mental Health

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Adolescent Marijuana Use Is Linked to Altered Neural Circuitry and Mood Symptoms

August 2018
Some teens' marijuana use has been linked to disrupted communication between two key regions in the brain’s reward circuitry at age 20. Disrupted communication between the regions was associated with poorer psychosocial functioning at age 22.

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Slow-Release Amphetamine Medication Benefits Patients With Comorbid Cocaine Addiction and ADHD

August 2016
Treatment with an extended-release stimulant medication plus cognitive behavioral therapy was associated with reductions in cocaine use and in attention-deficit/hyperactivity disorder symptoms in patients with both disorders.

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Varenicline Helps People With Mental Illness Maintain Abstinence From Smoking

November 2014
The finding from an 18-month-long clinical trial strengthens hope that pharmacotherapy can break nicotine’s especially tenacious hold on people with serious mental illness such as bipolar disorder or schizophrenia.

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Training Workshops Boost Approval of Contingency Management

August 2014
Clinicians associated with the Veterans Administration looked more favorably upon contingency management after attending training workshops on the use of the intervention. Despite being highly effective at decreasing drug use, contingency management is one of the least used among proven substance abuse treatments.

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Self-Control Protects Urban Minority Youths From Drug Use and Depressive Mood

July 2014
Interventions that bolster self-control in childhood and early adolescence might shield ethnic and racial minority adolescents and young adults from the burden of both drug use and depressive mood.

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Dr. Joni Rutter Q&A: How Basic Science Is Tackling Addiction

May 2014
One of NIDA’s goals is to try to understand the individual differences that contribute to whether or not someone who takes a drug will become addicted to it. Dr. Rutter’s research focuses on three types of differences: Environmental, developmental, and genetic and epigenetic.

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HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis

January 2014
Study patients with HIV­­–hepatitis C coinfection progressed to successive degrees of severity of liver fibrosis 9 years sooner than those infected with HCV alone. Further findings from the study suggest that suppressing HIV with antiretroviral medications may slow HCV-related liver fibrosis.

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