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NIDA Notes Articles: Addiction Science

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A Case for Studying Brain Asymmetry in Drug Use

September 2016
A new study proposes that research into the discrete roles played by the brain’s two hemispheres could yield important and actionable insights into drug use and addiction. Evidence indicates that two risk factors for substance use, impulsivity and craving, primarily reflect activity in the right and left hemispheres, respectively.

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Regular Marijuana Use Is Associated With Differences in Brain Gray Matter and Connectivity

September 2016
A brain imaging study strongly suggests that regular users of marijuana have smaller orbitofrontal cortex (OFC) volumes. Such a deficit could make it more difficult to change counterproductive behaviors, including drug use.

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Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

February 2016
The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

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Gene Transfer Therapy for Cocaine Addiction Passes Tests in Animals

January 2016
Giving mice a modified version of a naturally occurring gene blocks cocaine’s stimulant effects without affecting the animals’ physiological or metabolic health. The new evidence advances the proposed therapy a step closer to readiness for testing in people.

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