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NIDA Notes Articles: Addiction Science

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Molecular Alterations of DNA Contribute to Persistence of Memory

November 2011
In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.

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N-Acetylcysteine Postsynaptic Effect Limits Efficacy

January 2013
Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

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Narrative of Discovery: Can Magnets Treat Cocaine Addiction?

September 2015
Two researchers share their reasons for researching transcranial magnetic stimulation (TMS) for treating cocaine addiction, and describe challenges to moving forward this potentially promising therapy.

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Narrative of Discovery: Can Magnets Treat Cocaine Addiction? Part 3

March 2017
In the final installment of this series, Dr. Diana Martinez navigates the process for receiving NIH funding to test the efficacy of using transcranial magnetic stimulation as treatment for cocaine addiction.

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Neuroscience Blueprint Promotes Efficiency, Synergy

June 2008
Describes a knowledge- and resource-sharing system for NIH-funded neuroscientists to access to data, advanced research tools, and technical assistance.

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New Insight Into How Cues Cause Relapse to Cocaine

May 2014
A brain response occurs in the nucleus accumbens when rats encounter a cue that they associate with previous cocaine self-administration, but not a cue associated with a pleasurable non-drug experience. Moreover, the response correlates in time and intensity with the animals’ cue-induced relapse to cocaine-seeking.

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New Method Uncovers How Internal States Influence the Living Brain to Change Behavior

March 2012
In an innovative NIDA-funded study, published in Cell, scientists introduced a modified dopamine receptor gene into the brain of a living vinegar fly

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New Technique Links 89 Genes to Drug Dependence

September 2008
Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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NIDA Awards Prizes at International Science Fair

November 2009
Announces the 2009 high school student recipients of the Addiction Science Awards and describes their winning addiction-focused projects.

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NIDA Bestows Prizes at International Science Fair

September 2008
Announces the three winners of the NIDA and Scholastic Corporation 2008 Addiction Science Awards honoring high school students’ award-winning addiction-related projects.

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