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NIDA Notes Articles: Addiction Science

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Genetic Overlap Between Substance Abuse and Bipolar Disorder

April 2010

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

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Henry Yamamura Obituary

December 2008

Remembers Henry I. "Hank" Yamamura, an eminent neuropharmacologist who pioneered radioligand binding assays, contributing valuable knowledge about neurotransmitter transporters and receptors.

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How-To Guides Provide Tips for Publishing Addiction-Related Articles

April 2010
Describes a book and online tutorial for young investigators of addiction science that provides tips for publishing their studies in scholarly journals.

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Imaging Studies Elucidate Neurobiology of Cigarette Craving

December 2008

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

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Immune System Plays Unexpected Role in Brain Development

September 2008

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.

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Impacts of Drugs on Neurotransmission

March 2017

Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between brain cells. This article discusses the central importance of studying drugs’ effects on neurotransmission and describes some of the most common experimental methods used in this research. 

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In Animals, Receptor Puts Brakes on Nicotine Consumption

March 2012

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

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Investigators Map Functional Networks in the Rat Brain

June 2012

Researchers have mapped the fundamental functional organization of the rat brain and shown that it resembles that of the human brain.

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Long-Term Cocaine Abuse Linked With Impaired Heart Function

March 2008

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

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Long-Term Cocaine Self-Administration Depresses Brain Activity

December 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

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