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NIDA Notes Articles: Addiction Science

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Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

February 2016

The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

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Promising Advances in the Search for Safer Opioids

February 2017

New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

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Program Enhances Physician Knowledge on Substance Abuse

December 2010
Reports on an evaluation of the Chief Resident Immersion Training (CRIT) program to assess its effectiveness in improving knowledge, confidence, and preparedness to diagnose, manage, and teach about substance abuse.

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Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

January 2014

Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

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Peer Interaction Enhances Adolescent Rats' Drug Reward

April 2010
Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.

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Optical Technologies Expand Vistas Into the Brain

September 2008

Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.

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Office Meets Dynamic Challenges of Diversity

July 2011
Describes NIDA’s Special Populations Office which promotes addiction science that examines health disparities and foster research careers among members of underrepresented communities.

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Not All Mesolimbic Dopamine Neurons Are Alike

March 2008

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Nonmedical Opioid and Heroin Use Among High School Seniors

April 2017

This study analyzed the use of use of nonmedical opioids and heroin use among 68,000 high-school seniors participating in the NIDA-funded Monitoring the Future Study between 2009 and 2013.

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NIDA's Newest Division Mines Clinical Applications From Basic Research

October 2007

Describes the role of the Division of Clinical Neuroscience and Behavioral Research in NIDA’s drug abuse and addiction research plan.

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