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NIDA Notes Articles: Addiction Science

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A Case for Studying Brain Asymmetry in Drug Use

September 2016
A new study proposes that research into the discrete roles played by the brain’s two hemispheres could yield important and actionable insights into drug use and addiction. Evidence indicates that two risk factors for substance use, impulsivity and craving, primarily reflect activity in the right and left hemispheres, respectively.

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A Gene Links Impulsivity and Drug Use Vulnerability

June 2018
Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.

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A Genetic Nexus of Obesity and Smoking

October 2014
Research shows that some gene variants that influence body mass index also shape smoking behaviors.

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Adolescent Marijuana Use Is Linked to Altered Neural Circuitry and Mood Symptoms

August 2018
Some teens' marijuana use has been linked to disrupted communication between two key regions in the brain’s reward circuitry at age 20. Disrupted communication between the regions was associated with poorer psychosocial functioning at age 22.

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Amphetamine Diverts the Brain’s Path to Maturity

July 2018
A key mechanism of adolescent brain development can be disrupted by amphetamine.

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Animal Study Suggests Marijuana May Affect Future Offspring’s Susceptibility to Heroin

February 2015
Can marijuana use put offspring at heightened risk for opiate addiction, even if the use stops before the offspring are conceived? Results from a recent NIDA-funded study are consistent with other studies suggesting that a parent’s history of drug use, even preconception, may affect a child’s brain function and behavior.

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Animation: The Rise and Fall of the Cocaine High

November 2014
This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

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Brain Imaging Predicts Relapse to Cocaine

September 2015
A NIDA-supported study has found that a cocaine-addicted person’s chance of managing 1 whole year of abstinence correlates with activity levels in these impaired motivational and decision-making brain areas.

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Childhood Maltreatment Changes Cortical Network Architecture and May Raise Risk for Substance Use

November 2015
Young adults who had been maltreated as children differed from others who had not been maltreated in the connectivity of nine cortical regions. The differences could compromise the maltreated group’s basic social perceptual skills, ability to maintain a healthy balance between introversion and extroversion, and ability to self-regulate their emotions and behavior.

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Cocaine-Induced Increase in an Immune Protein Promotes Addiction Behaviors in Mice

October 2018
Cocaine produces a portion of its rewarding effects by increasing levels of granulocyte-colony stimulating factor (G-CSF) in the brain’s reward center. Treatments that prevent G-CSF signaling in the nucleus accumbens might reduce motivation to use cocaine.

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