En español
NIDA

NIDA Notes Articles: Genetics

NIDA Notes Category Graphic

Stress Receptor Mediates Lifelong Consequences of Early Trauma

November 2012
NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

NIDA Notes Category Graphic

Male Rats’ Cocaine Exposure Affects Their Offspring’s Drug Responses

August 2013
In a surprising finding, male rats who used cocaine sired male offspring who later exhibited blunted responses to the drug. Researchers determined the cause was an epigenetic alteration.

NIDA Notes Category Graphic

Study Finds Genetic Influence on African Americans’ Smoking

November 2013
A meta-analysis of 13 genome-wide association studies of African Americans’ smoking patterns confirms the significance of genetic variation in region 15q25.1. The analysis also tentatively implicates several genome locations that have not previously been associated with smoking behaviors.

NIDA Notes Category Graphic

Dr. Joni Rutter Q&A: How Basic Science Is Tackling Addiction

May 2014
One of NIDA’s goals is to try to understand the individual differences that contribute to whether or not someone who takes a drug will become addicted to it. Dr. Rutter’s research focuses on three types of differences: Environmental, developmental, and genetic and epigenetic.

NIDA Notes Category Graphic

Gene Variants Reduce Opioid Risks

June 2014
Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

NIDA Notes Category Graphic

A Genetic Nexus of Obesity and Smoking

October 2014
Research shows that some gene variants that influence body mass index also shape smoking behaviors.

NIDA Notes Category Graphic

Animal Study Suggests Marijuana May Affect Future Offspring’s Susceptibility to Heroin

February 2015
Can marijuana use put offspring at heightened risk for opiate addiction, even if the use stops before the offspring are conceived? Results from a recent NIDA-funded study are consistent with other studies suggesting that a parent’s history of drug use, even preconception, may affect a child’s brain function and behavior.

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics