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NIDA Notes Articles: Genetics

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Transcription Factor E2F3a Mediates Cocaine’s Effects on Gene Expression and Addiction-Related Behaviors

February 2019
This study demonstrated that cocaine increases expression of the protein E2F3a in the brain’s reward system. The changes in E2F3a levels in the nucleus accumbens are tied to addiction-related behaviors and to altered gene expression.

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How Cocaine Cues Get Planted in the Brain

September 2018
An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.

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A Gene Links Impulsivity and Drug Use Vulnerability

June 2018
Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.

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