May 2016 Teens who avidly seek new and intense sensations are more likely to start using substances, but are not more likely to use them regularly within the next 3 years unless they also are prone to devalue distant consequences and act impulsively.
Two researchers share their reasons for researching transcranial magnetic stimulation (TMS) for treating cocaine addiction, and describe challenges to moving forward this potentially promising therapy.
September 2015 In mice, a cocaine-induced imbalance in the activity of two key populations of neurons in the reward system persists for a longer period after repeated exposure to the drug. For long-term users, this change could both weaken the cocaine “high” and strengthen the compulsion to seek the drug.
Within the 2 weeks prior to responding to a nationwide survey, 28 percent of high school seniors were in a vehicle whose driver had been using marijuana or another illicit drug, or had drunk 5 or more alcoholic drinks.
July 2014 The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.