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NIDA Notes Articles: People with Drug Use Disorders

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Naltrexone Implant Outperforms Daily Pill in Russian Trial

November 2013
More than half of heroin-addicted patients treated with naltrexone via an implanted delivery device maintained abstinence throughout a 6-month clinical trial in Saint Petersburg, Russia. The implant device, which releases a steady dose of naltrexone continuously for 2 months, averted relapse to heroin use three times as effectively as daily oral doses of the medication.

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Naltrexone via Skin Patch Proves Effectiveness of New Technology

November 2009
Reports on a new device that creates tiny painless punctures in the skin to allow medication to flow evenly from a skin patch into dermal capillaries and the bloodstream.

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Naltrexone-Nicotine Patch Combination Shows Promise

April 2007
Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

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New Technique Links 89 Genes to Drug Dependence

September 2008
Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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New Tools and Strategies to Bolster Behavioral Therapy

October 2010
Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

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New Vaccines Are Being Developed Against Addiction and Relapse

December 2008
Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

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Nicotine Makes Mouse Brain More Responsive to Cocaine

February 2013
Nicotine sensitizes the mouse brain to the addictive effects of cocaine, according to recent NIDA-supported research. The results accord with the hypothesis that a person’s initial use of an addictive substance physiologically sensitizes his or her brain to the rewarding and addictive effects of other substances. If the findings carry over to people, then preventing youths from smoking might reduce their vulnerability to cocaine abuse and addiction, and cocaine-dependent individuals might ease their path to recovery by quitting smoking.

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NIDA Cosponsors Mentoring Service for Clinicians Advising Substance-Abusing Patients

July 2011
Highlights a free service that provides primary care clinicians with advice from experts in addiction medicine on addressing substance abuse with patients in the primary care setting.

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NIDA Launches Criminal Justice Publication in Chicago

October 2006
Highlights a publication that outlines 13 research-based principles of successful treatment of drug abusers in the criminal justice system.

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Oxycodone Vaccine Passes Early Tests

May 2013
A new vaccine hindered the often-abused prescription opioids oxycodone and hydrocodone from entering the brain and suppressed one of the drugs’ signature central nervous system effects. The findings warrant continued development of the vaccine as a potential aid in the treatment of oxycodone and hydrocodone abuse and dependence.

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