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NIDA Notes Articles: People with Drug Use Disorders

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Medical Care During Addiction Treatment Reduces Hospital Use

February 2007
Reports on an analysis comparing three types of addiction treatment programs: methadone maintenance programs, long-term residential programs, and nonmethadone programs.

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Methadone Reduces Rats' Cocaine Seeking

December 2008
Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Methamphetamine Abuse Alters Response to Facial Cues

October 2009
Highlights research showing methamphetamine abusers may have more difficulty than nonabusers in responding with empathy and self-control to people who are experiencing intense emotions.

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Methamphetamine Abuse Undermines Dental Health

July 2011
Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.

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Methamphetamine Abusers Show Increased Distractibility

April 2009
Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

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Methylphenidate for Comorbid Cocaine Abuse, ADHD

October 2006
Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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More Convenient Preparations of Buprenorphine Pass Test

July 2012
Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Most People Entering Drug Treatment Have Additional Mental Health Problems

November 2009
Highlights data on the prevalence of people entering substance abuse treatment programs who also reported having at least one co-occurring mental health problem.

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N-Acetylcysteine Postsynaptic Effect Limits Efficacy

January 2013
Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

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