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NIDA Notes Articles: People with Drug Use Disorders

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Oxycodone Vaccine Passes Early Tests

May 2013
A new vaccine hindered the often-abused prescription opioids oxycodone and hydrocodone from entering the brain and suppressed one of the drugs’ signature central nervous system effects. The findings warrant continued development of the vaccine as a potential aid in the treatment of oxycodone and hydrocodone abuse and dependence.

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Early-Onset, Regular Cannabis Use Is Linked to IQ Decline

August 2013
Regular cannabis use that starts in adolescence strips away IQ, a NIDA-supported study suggests. Participants who initiated weekly cannabis use before age 18 dropped IQ points in proportion to how long they persisted in using the drug. Persistent cannabis users’ cognitive difficulties were evident to friends and family and measurable on a battery of tests.

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Study Parses Comorbidity of Cannabis Use and Social Anxiety

October 2013
People with cannabis use disorder (CUD) are likely also to have social anxiety disorder (SAD), and comorbid SAD is associated with greater severity of cannabis-related problems. These findings highlight the importance of assessing CUD patients for SAD, as that disorder can be both a contributing cause and a consequence of CUD. Treating both disorders may be a key to helping patients recover from each.

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Naltrexone Implant Outperforms Daily Pill in Russian Trial

November 2013
More than half of heroin-addicted patients treated with naltrexone via an implanted delivery device maintained abstinence throughout a 6-month clinical trial in Saint Petersburg, Russia. The implant device, which releases a steady dose of naltrexone continuously for 2 months, averted relapse to heroin use three times as effectively as daily oral doses of the medication.

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