En español
NIDA

NIDA Notes Articles: Basic Science

NIDA Notes Category Graphic

Not All Mesolimbic Dopamine Neurons Are Alike

March 2008
Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

NIDA Notes Category Graphic

Optical Technologies Expand Vistas Into the Brain

September 2008
Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.

NIDA Notes Category Graphic

Peer Interaction Enhances Adolescent Rats' Drug Reward

April 2010
Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.

NIDA Notes Category Graphic

Physical Activity Reduces Return to Cocaine Seeking in Animal Tests

April 2012
Two independent animal studies suggest that aerobic exercise might help cocaine abusers establish and maintain abstinence.

NIDA Notes Category Graphic

Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

January 2014
Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

NIDA Notes Category Graphic

Prenatal Cocaine Exposure Increases Monkeys' Impulsivity Into Adulthood

July 2012
Prenatal drug exposure can have behavioral effects that last well into adulthood, according to two studies of adult monkeys prenatally exposed to cocaine. In the first study, drug-exposed monkeys exhibited less flexibility than controls in adjusting to changing circumstances; in the second study, drug-exposed males exhibited a greater preference than controls for having rewards right away, a sign of impulsivity.

NIDA Notes Category Graphic

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

April 2009
Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

NIDA Notes Category Graphic

Promising Advances in the Search for Safer Opioids

February 2017
New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

NIDA Notes Category Graphic

Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

February 2016
The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

NIDA Notes Category Graphic

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

December 2009
Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Pages

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics