En español
NIDA

NIDA Notes Articles: Basic Science

NIDA Notes Category Graphic

Researchers Develop a New Tracer for Cannabinoid Receptor

March 2008
Describes a new chemical tracer that binds specifically to cannabinoid receptors making it potentially useful in future research to clarify the relationship between the receptors and drug abuse.

NIDA Notes Category Graphic

Regular Marijuana Use Is Associated With Differences in Brain Gray Matter and Connectivity

September 2016
A brain imaging study strongly suggests that regular users of marijuana have smaller orbitofrontal cortex (OFC) volumes. Such a deficit could make it more difficult to change counterproductive behaviors, including drug use.

NIDA Notes Category Graphic

Receptor Complexes Link Dopamine to Long-Term Neuronal Effects

October 2009
Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

NIDA Notes Category Graphic

Rats Reared Alone Show ADHD Signs

December 2009
Describes an animal study showing that rats raised in isolation may prove useful in future studies exploring the neurobiology that links impulsivity and vulnerability to addiction.

NIDA Notes Category Graphic

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

December 2009
Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

NIDA Notes Category Graphic

Protein Diminishes Cocaine Reward and Cocaine-Related Learning in Animals

February 2016
The protein acid-sensing ion channel 1A (ASIC1A) is naturally present in the brain and reduces laboratory animals' attraction to environments in which they have experienced cocaine's effects.

NIDA Notes Category Graphic

Promising Advances in the Search for Safer Opioids

February 2017
New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

NIDA Notes Category Graphic

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

April 2009
Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

NIDA Notes Category Graphic

Prenatal Cocaine Exposure Increases Monkeys' Impulsivity Into Adulthood

July 2012
Prenatal drug exposure can have behavioral effects that last well into adulthood, according to two studies of adult monkeys prenatally exposed to cocaine. In the first study, drug-exposed monkeys exhibited less flexibility than controls in adjusting to changing circumstances; in the second study, drug-exposed males exhibited a greater preference than controls for having rewards right away, a sign of impulsivity.

NIDA Notes Category Graphic

Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

January 2014
Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

Pages

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics