November 2011 In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.
Describes research findings that show that chronic cocaine abuse may change the production of many proteins in the neurons of the brain’s reward system, aiding in our understanding how the drug causes addiction.
October 2010 Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.
Describes research results reporting that people who favor novelty have lower-than-average availability of a receptor that inhibits dopamine's release from neurons, which likely stimulates the activity of reward circuits.
April 2010 Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.
Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.