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NIDA Notes Articles: Treatment

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Testing a Prospective Medication To Help People Avoid Relapse

March 2016
This NIDA Notes animation depicts a basic experiment that researchers use to test whether a prospective new medication can prevent relapse to drug addiction.

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Switching to Reduced-Nicotine Cigarettes May Aid in Quitting Smoking

October 2018
Smokers who switch to cigarettes with very low nicotine content may experience mild and transient increases in some withdrawal symptoms. Cigarettes with reduced nicotine will be easier to quit than the cigarettes marketed at present.

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Slow-Release Amphetamine Medication Benefits Patients With Comorbid Cocaine Addiction and ADHD

August 2016
Treatment with an extended-release stimulant medication plus cognitive behavioral therapy was associated with reductions in cocaine use and in attention-deficit/hyperactivity disorder symptoms in patients with both disorders.

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Quinine as a Tracer for Medication Adherence

September 2016
Patients who don’t take their medications as prescribed often put themselves at risk for problems including misdiagnoses, complications, and death. A study suggests that adding low doses of quinine to patients’ medications could provide an inexpensive, reliable, and safe method of monitoring whether patients are taking their medications as directed.

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Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards

October 2018
Mindfulness-Oriented Recovery Enhancement (MORE) reduces opioid misuse among chronic pain patients. MORE shifts patients' attention away from drug cues and toward cues for natural rewards.

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Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT

June 2018
A clinical trial found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they maintained this advantage through a 6-month follow-up.

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Opioid Agonist Treatment Reduces Societal Costs of Crime

August 2017
Patients who initiate time-unlimited opioid-agonist therapy will generate lower average total crime-related costs over the next 6 months than patients who initiate a 21-day detoxification regimen.

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Novel Compound Alleviates Hard-to-Treat Pain in Mice

June 2018
A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.

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Nonmedical Treatment for Cocaine Addiction Shows Promise in Pilot Trial

November 2016
Patients who received transcranial magnetic stimulation (TMS) were more likely to abstain from cocaine than patients who received medications for symptoms associated with abstinence. Researchers concluded that TMS appears to be safe and its efficacy as a treatment for cocaine addiction deserves to be evaluated in a larger clinical trial.

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New Studies Clarify Risk Factors for Neonatal Abstinence Syndrome

January 2019
A recent NIDA-sponsored study found higher rates of NAS among males than among females. A second study found that, among infants whose mothers were treated with buprenorphine while pregnant, NAS was more severe among those whose mothers used other substances.

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