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NIDA Notes Articles: Stimulants

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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Cocaine Alters Production of Hundreds of Proteins

March 2011
Describes research findings that show that chronic cocaine abuse may change the production of many proteins in the neurons of the brain’s reward system, aiding in our understanding how the drug causes addiction.

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Drugs Contribute to High Rates of Sexually Transmitted Diseases Among Juvenile Offenders

July 2011
Describe a study of newly arrested youths where researchers found correlations between the youths' prevalence of these sexually transmitted diseases and their cocaine and marijuana use.

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Methamphetamine Abuse Undermines Dental Health

July 2011
Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.

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Medication Reduces Rats' Return to Methamphetamine Seeking

July 2011
Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

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Disruption of Neuron Production in Adult Rats Increases Cocaine Taking

November 2011
Drug abuse may diminish production of new neurons in the brain’s hippocampus and thereby increase vulnerability to drug addiction.

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Marker for Neuronal Damage Resolves a Year after Methamphetamine

December 2011
New results extend previous findings that some methamphetamine-induced neuronal damage resolves after a year of abstinence.

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Stimulant Abusers' Regard for Future Improves With Memory Training

December 2011
Researchers correlate stimulant abusers’ improved performance on a memory training exerc ise with reductions in delay discounting.

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Physical Activity Reduces Return to Cocaine Seeking in Animal Tests

April 2012
Two independent animal studies suggest that aerobic exercise might help cocaine abusers establish and maintain abstinence.

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Animal Research Advances Effort to Develop Vaccines Against Cocaine, Heroin Abuse

September 2012
New vaccines that aim to promote recovery from cocaine and heroin abuse showed promise in animal testing. Both vaccines induced rats’ immune system to produce high titers of antibodies that inhibit the target drug from reaching the brain. The rats’ behaviors when given access to the target drug indicated that the vaccines reduced the reinforcing effects that, in recovering people, can cause lapses to turn into relapses.

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