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NIDA Notes Articles: Opioids

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Patch Delivers Buprenorphine for Heroin Detox

November 2009
Describes research on the effectiveness of a buprenorphine patch to alleviate opioid withdrawal symptoms of newly abstinent heroin abusers.

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Methadone Reduces Rats' Cocaine Seeking

December 2008
Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Reducing Postpartum Drug Use

December 2008
Highlights a computerized intervention that reduced new mothers' drug abuse in the first 4 months postpartum as reported in a clinical trial of 107 women who abused drugs.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008
Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Basic Science Discoveries Yield Novel Approaches to Analgesia

September 2008
Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

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Reduced Longevity Among Male Heroin Abusers, 1962-1997

June 2008
Reviews the changing lifespan of heroin abusers as compared with that of the general U.S. population based on 1962-1997 data.

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Not All Mesolimbic Dopamine Neurons Are Alike

March 2008
Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Chromosome 17 Harbors Opioid Dependence Genes

March 2008
Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Incentives Reduce Stimulant Abuse During Methadone Maintenance

April 2007
Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

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Antipsychotic Drug Prevents Morphine Tolerance in Mice

April 2007
Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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